Abstract:
:The in vivo and in vitro drug release profiles from a self-setting bioactive CaO-SiO2-P2O5 glass bone cement containing indomethacin as a model drug were investigated. The cement containing 2% and 5% indomethacin (IMC) powder hardened within 5 min after mixing with ammonium phosphate buffer. After setting, in vitro drug release from drug-loaded cement pellets in a simulated body fluid (SBF) at pH 7.25 and 37 degrees C continued for two weeks. The hardened cement gradually formed low-crystallinity hydroxyapatite during the drug release test in SBF. An IMC-loaded cement device (2% and 5% drug) was implanted in the subcutaneous tissue on the back of rats. The in vivo IMC release from the cement increased and attained maximum levels (Cmax of 2% and 5% drug-loaded cements was 0.27 and 3.37 micrograms/ml, respectively) at Tmax, 3 and 0.5 d, respectively, upon subcutaneous (s.c.) administration in rats. This suggested that the s.c. administration of the cement provided IMC release for a much longer period than s.c. administration of the solution, and the plasma IMC concentration was dependent on the drug concentration in the cement. The plasma IMC concentration and the area under the curve from 2% and 5% IMC-loaded cements in rats were dependent on the concentration of IMC in the cements. The in vivo IMC concentration in plasma obtained by the deconvolution method was much lower than that delivered in SBF in vitro. Scanning electron microscopy and photomicrographs of cross sections showed that the bioactive bone cement had excellent biocompatibility with the surrounding soft tissues.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Otsuka M,Nakahigashi Y,Matsuda Y,Kokubo T,Yoshihara S,Fujita H,Nakamura Tsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
291-302issue
5eissn
0959-2989issn
1878-3619journal_volume
7pub_type
杂志文章abstract::The interactions between carbon nanotubes and important biomolecules, above all collagen molecules, have not been studied in detail. This situation is partly due to the fact that CNT are solid entities, while most of the biomolecules can be prepared in solution. We used turbidity as a means of evaluating the interacti...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2009-0557
更新日期:2009-01-01 00:00:00
abstract::The bonding strength of porcelains to metals depends on the oxide layer between the porcelain and the metal. Oxidation of a metal surface increases the bonding strength, whereas excessive oxidation decreases it. Titanium and its alloys are gaining acceptance for dental use since they exhibit excellent biocompatibility...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To study the comprehensive biomechanical properties of the cancellous bone of distal femur through a series of mechanical tests, and provide relevant subjects with the basic technical data. BACKGROUND:The study on bone mechanics is a commonly used approach to evaluate the biomechanical competency of bone. Th...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Polylactic acid (PLA)/styrene-ethylene-butylene-styrene (SEBS) composites were prepared by melt blending. Differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WXRD) were used to characterize PLA and PLA/SEBS composites in terms of their melting behavior and crystallization. Curves from thermal gra...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151300
更新日期:2015-01-01 00:00:00
abstract::Hydroxyapatite is widely utilized as a component in dental hygiene agents. The ability to adsorb and remove dental plaque adhering to tooth surfaces is recognized as an important property of hydroxyapatite particles. In this study, the adsorptive ability of hydroxyapatite was evaluated based on its adsorptive amount a...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Electroencephalograph (EEG) signals feature extraction and processing is one of the most difficult and important part in the brain-computer interface (BCI) research field. EEG signals are generally unstable, complex and have low signal-noise ratio, which is difficult to be analyzed and processed. To solve this problem...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141113
更新日期:2014-01-01 00:00:00
abstract::Poly(propylene fumarate-co-ethylene glycol) random (PPF-1) and block (PPF-2) copolymer oligomers were prepared. Comparing the setting characteristics of PPF-1 and PPF-2 with comonomer n-vinyl pyrrolidone (n-VP) and swelling characteristics of cured PPF-1 and PPF-2, lower setting temperature and setting time was observ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Adhesive resin composite, which is used to bond orthodontic bracket to tooth surface is exposed to the influence of wear by tooth brushing and wear may influence loosening of the bracket. OBJECTIVE:The aim of this study was to evaluate in vitro the effect of tooth brushing on the adhesion strength of orthod...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161592
更新日期:2016-09-28 00:00:00
abstract::The selection of best material pair in the hip prosthetics design for improved performance and life relies on the estimation of hip joint contact stresses and contact pressure distribution during various dynamic loading cycles: Climbing Upstairs, Climbing downstairs and Knee bending. The maximum Von Mises stress, cont...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-181019
更新日期:2018-01-01 00:00:00
abstract::The goal of the study was to determine material constants of cancellous tissue in a compression test taking into account stress-strain characteristics. The nineteen test samples were resected from a femoral head of a patient qualified for a hip replacement surgery. During the compression tests, load-displacement curve...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-180999
更新日期:2018-01-01 00:00:00
abstract::In this work composite materials, based on quartz fibers and epoxy resins, were employed with the aim to restore damaged teeth. The composite materials were chosen because they show biomechanical features very similar to that of the dentine, the main constituent of the tooth. Extracted teeth were rebuilt with two diff...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Various tissue-engineered vascular grafts have been studied in order to overcome the clinical disadvantages associated with conventional prostheses. However, previous tissue-engineered vascular grafts have possessed insufficient mechanical properties and thus have generally required either preoperative cellular manipu...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141023
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Adipose tissue engineering has been studied as an alternative to current options for breast reconstruction, such as lipofilling, flap reconstruction, and silicone implants. Previously, we demonstrated that a poly(L-lactic acid) mesh containing a collagen sponge, containing neither cells nor growth factors, c...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-201103
更新日期:2020-01-01 00:00:00
abstract::The effect of hydroxyapatite sol (HAm) which is composed of unheating hydroxyapatite microcrystal particle on cell proliferation and alkaline phophatase activity in osteoblastic MC3T3-E1 cells, was examined in the presence or absence of fetal calfe serum (FCS) in the medium. In the absence of FCS, HAm inhibited the ce...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::In this investigation, ultrasonic parameters of kidney stones are measured, in vitro, using a double probe ultrasonic-through-transmission technique. Due to the complex chemical structure of these stones, a large variation in the values of the ultrasonic parameters is found. A correlation between ultrasonic properties...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Electrospinning is a highly effective method in order to generate nano-scaled fibers. In conventional electrospinning technique, geometry of nanofibers are mostly random due to the chaotic behavior of polymer jet. OBJECTIVE:Purpose of this study is to produce aligned nanofibers from PVP polymers with advanc...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-181017
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Gait analysis, such as portable gait rhythmogram (PGR), provides objective information that helps in the quantitative evaluation of human locomotion. OBJECTIVE:The purpose of this study was to assess the reliability of PGR in post-stroke patients. METHODS:Two raters (A and B) examined 48 post-stroke patien...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-206007
更新日期:2020-01-01 00:00:00
abstract::Numerous constitutive models describing the mechanical properties of tendons have been proposed during the past few decades. However, few were widely used owing to the lack of implementation in the general finite element (FE) software, and very few systematic studies have been done on selecting the most appropriate pa...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2011-0653
更新日期:2011-01-01 00:00:00
abstract::The stability of the Co-Cr-Mo dental alloy immersed in artificial salivas (pH 6.7) was investigated over 24 h. Three artificial salivas have been studied: saline saliva (saliva I); saline saliva buffered with phosphate ions (saliva II) and saliva II plus mucin molecules (saliva III). For all the systems, open circuit ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141241
更新日期:2015-01-01 00:00:00
abstract::In this study, design optimization of a tooth implant-supported fixed prosthesis was investigated theoretically. A three-dimensional finite element analysis was utilized to simulate the stress distribution and deformation, with an emphasis on the material selection for various parts of the prosthesis. This mandibular ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Resorbable ceramics can promote the bony integration of implants. Their rate of degradation should ideally be synchronized with bone regeneration. This study examined the effect of rapidly resorbable calcium phosphate ceramics 602020, GB14, 305020 on adherence, proliferation and morphology of human bone-derived cells ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2012-0678
更新日期:2011-01-01 00:00:00
abstract::In this study, biocompatibility of 17-4 PH stainless steel foam for biomedical implant applications was investigated. 17-4 PH stainless steel foams having porosities in the range of 40-82% with an average pore size of around 600 μm were produced by space holder-sintering technique. Sintered foams were precipitation ha...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2011-0671
更新日期:2011-01-01 00:00:00
abstract::To investigate the inhibition effect of oxymatrine induces human lung cancer A549 cells apoptosis. The A549 cells were cultured for 24 h, than the various concentration of oxymatrine (2 mmol/L, 4 mmol/L, 8 mmol/L, 15 mmol/L) were added into different experimental group cells, and 5-fluorouracil were added into the pos...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151302
更新日期:2015-01-01 00:00:00
abstract::In a previous work by the author [H.S. Hedia and M. Nemat-Alla, Design optimization of functionally graded dental implant, submitted to be published in the J. Bio-Medical Materials and Engineering], a functionally graded material dental implant was designed without cansellous bone in the model. In this investigation t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Based upon previous research on the relation between hip prosthesis designs and strain distributions in a proximal femur model, a prototype of a "physiological" hip prosthesis was designed and manufactured. Strain gauge measurements on a dry femur before and after implantation of this prosthesis were made in different...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Chitosan oligosaccharides graft polycaprolactone copolymer (PHCSO-g-PCL) has been synthesized via initiating the polymerization of e-caprolactone (CL) monomer through an amino group protection route using phthaloyl chitosan oligosaccharide (PHCSO) as intermediate. The grafting reaction was carried out in Pyridine at 1...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141013
更新日期:2014-01-01 00:00:00
abstract::The objective of the present study was to find a standard substance for use as a reference in the cytotoxicity assay of biomaterials, as an alternative to animal experiments in recent years. Eight kinds of rubber were made in a plate shape to keep their surface area at 1 cm2 against 10 ml of extract volume. They were ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::DNA-binding proteins are involved and play a crucial role in a lot of important biological processes. Hence, the identification of the DNA-binding proteins is a challenging and significant problem. In order to reveal the intrinsic information correlated to DNA-binding, nine classes of candidate features based on diffe...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151491
更新日期:2015-01-01 00:00:00
abstract::Using a wet method, we have synthesized octacalcium phosphate carbonate, in which HPO42- in octacalcium phosphate is replaced with CO32-. The physical, crystal, and chemical properties of this new material were compared to octacalcium phosphate, Ca-deficient hydroxyapatite, and Ca-deficient carbonate apatite using X-r...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171651
更新日期:2017-01-01 00:00:00
abstract::The method used in this paper is developed to estimate the degree of viscoelasticity of the blood vessel wall in a noninvasive mechanical method. In this proposed method, we can obtain an output waveform connected with mechanical behavior of blood vessels by using Ultrasonic Doppler Effect Sensory (UDES). Characterizi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00