Abstract：
:The objective of the present study was to find a standard substance for use as a reference in the cytotoxicity assay of biomaterials, as an alternative to animal experiments in recent years. Eight kinds of rubber were made in a plate shape to keep their surface area at 1 cm2 against 10 ml of extract volume. They were extracted by the following three extraction methods (a) dynamic extraction at 200 rpm gyration on alumina balls at 37 degrees C for 24 h; (b) static extraction at 37 degrees C for 24 h and (c) extraction by heating in an autoclave at 121 degrees C for 60 min. At the end of each period each extract was examined for cell viability based on an evaluation by neutral red uptake. These methods were repeated up to seven times. Two kinds of chemicals were also tested. The extracts obtained were used to treat human gingival fibroblasts that have been cultured with DMEM supplemented with 5% fetal bovine serum into a 96 well tissue culture plate by 1 x 10(5) cells/ml, in an incubator aerated with 5% CO2, and 95% humidified air at 37 degrees C for 48 h. The extracts of ethylene-propylene, butyl, nitrile rubbers, and two kinds of chemicals yielded strong cytotoxicity in all three kinds of extraction methods, while chloroprene, fluorine-contained, isoprene, India, and silicone rubbers showed little cytotoxicity. The results obtained by the three kinds of extraction methods revealed no differences in the order of cytotoxicity of the materials tested.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Oshima H,Nakamura Msubject
Has Abstractpub_date
1994-01-01 00:00:00pages
327-32issue
4eissn
0959-2989issn
1878-3619journal_volume
4pub_type
杂志文章abstract：:Milkvetch root as a medicine has been used for more over 2000 years in China, can strengthen immune function, protect liver, promote urination, resist aging and stress, reduce blood pressure and extensively resist bacterium. This study explored the effects of milkvetch root on the immune function of patients with a de...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章,随机对照试验
doi：10.3233/BME-151517
更新日期：2015-01-01 00:00:00
abstract：:Sunscreens that absorb UV light without photodegradation could reduce skin cancer. Polyvinyl silsesquioxanes are known to have greater thermal and photochemical stability than organic compounds, such as those in sunscreens. This paper evaluates the UV transparency of vinyl silsesquioxanes (VS) and its hybrids with SiO...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130853
更新日期：2014-01-01 00:00:00
abstract：:Sino-atrial node cells (SANCs) play a significant role in rhythmic firing. To investigate their role in arrhythmia and interactions with the atrium, computer simulations based on cellular dynamic mathematical models are generally used. However, the large-scale computation usually makes research difficult, given the li...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151365
更新日期：2015-01-01 00:00:00
abstract：:Based upon previous research on the relation between hip prosthesis designs and strain distributions in a proximal femur model, a prototype of a "physiological" hip prosthesis was designed and manufactured. Strain gauge measurements on a dry femur before and after implantation of this prosthesis were made in different...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:The first metatarsophalangeal (MTP) joint is a critical component for normal walking. The present study aimed to investigate the effects of restricting the flexion-extension motion of the first MTP joint on human walking gait. Ten male participants were recruited to perform walking trials under barefoot (BF) and the f...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141073
更新日期：2014-01-01 00:00:00
abstract：:In a previous work by the author [H.S. Hedia and M. Nemat-Alla, Design optimization of functionally graded dental implant, submitted to be published in the J. Bio-Medical Materials and Engineering], a functionally graded material dental implant was designed without cansellous bone in the model. In this investigation t...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti-6Al-4V (3.5-5.3% V; 5.3-6.8% Al; balance -Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory r...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-161608
更新日期：2016-01-01 00:00:00
abstract：:Low-dose computed tomography reconstruction is an important issue in the medical imaging domain. Sparse-view has been widely studied as a potential strategy. Compressed sensing (CS) method has shown great potential to reconstruct high-quality CT images from sparse-view projection data. Nonetheless, low-contrast struct...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151437
更新日期：2015-01-01 00:00:00
abstract：:A multidirectional pin-on-plate reciprocating machine was used to compare the wear performance of UHMWPE sliding against cast cobalt chrome (CoCr) plates that were either untreated or coated with Amorphous Diamond Like Carbon (ADLC). The test conditions were based on a 1/5 scale model representative of in vivo motion ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:This paper presents an X-ray diffraction method of measuring the residual stress/strain in bone tissue of rabbit's tibia. To derive the residual stress, bone powder of the diameter less than 40 micrometers was used as a control specimen at non-stressed state. From the X-ray measurements, it was clear that the distribu...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Commercially pure titanium (CPT) substrate was subjected to porcelain firing and bond strengths under three-point bending mode (span length: 15 mm; crosshead speed: 0.5 mm/min) were evaluated. Experimental variables included surface treatments of CPT and porcelain firing schedules. Variables for the surface treatments...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:A crucial role during the implementation of volume visualization is to identify the optimal transfer function, since the vital information and structure can be highlighted and revealed. The boundary of the volume is shared by respective portion of the two materials formed out of it, which causes undesirable thickening...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141123
更新日期：2014-01-01 00:00:00
abstract：:Two surface analytical spectroscopic techniques (namely, angular-dependent X-ray photoelectron spectroscopy and static secondary ion mass spectrometry) were used to characterize the nature and composition of the surface and near-surface layers formed on three biomedical polymers (namely, low-density polyethylene, expa...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:To select tag single nucleotide polymorphisms (SNPs) within and around human p75 neurotrophin receptor (p75NTR) gene in Chinese Han population, the sequence involving p75NTR gene as well as the upstream and downstream of the gene was identified according to the data from National Center for Biotechnology Information (...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141213
更新日期：2014-01-01 00:00:00
abstract：:The effect of carbonate in reducing the crystal size of precipitated hydroxyapatite by approximately an order of magnitude has not been used previously in the preparation of gel monoliths for the fabrication of carbonate hydroxyapatite ceramics. The aim of this study was to devise a method whereby gel monoliths of car...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Reoperation of aldehyde tanned bioprotheses due to calcific degeneration remains their major drawback. Based on experiments studying mechanisms and factors that influence the time phase, extent and progression of calcification and evaluating the efficiency of anticalcification treatments and the effects of surface see...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Crystalline hydroxyapatite (HA) powder was coated on titanium substrate by radio frequency (RF) magnetron sputtering. The coating was homogeneous thin film and the thickness was 1microm. Crystallinity of the HA coating was low and Ca/P ratio was high as 3.0. Particle sizes were 40 to approximately 100 nm, and the crys...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Robotized endoscope holder in laparoscopic surgeries allows surgeons to control the endoscope without the assistants' intervention. In this paper, a new method is proposed for the automatic 3D-tracking of laparoscopic instruments in real-time to provide more convenient interactions between surgeons and the robotized e...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141083
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Accelerated hydrothermal aging has long been one of the most widely accepted quality control tests for simulating low-temperature degradation (LTD) in zirconia-containing implants used in total hip arthroplasty (THA). However, it is still unclear how much consistency there is between the experimental predict...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-201083
更新日期：2020-01-01 00:00:00
abstract：:To investigate the inhibition effect of oxymatrine induces human lung cancer A549 cells apoptosis. The A549 cells were cultured for 24 h, than the various concentration of oxymatrine (2 mmol/L, 4 mmol/L, 8 mmol/L, 15 mmol/L) were added into different experimental group cells, and 5-fluorouracil were added into the pos...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151302
更新日期：2015-01-01 00:00:00
abstract：:The paper presents an application of the FSI technique to determine hemodynamics in the abdominal aorta (AA). To establish boundary conditions for the FSI study, MR anatomical data and 4D MRI velocity-mapping data (in three blood flow velocity directions and time) were collected to acquire realistic geometry of the AA...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151312
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:We aimed to develop a novel ultrasound system and examine its feasibility for noninvasively detecting thoracic aortic aneurysm (TAA) in clinical settings. METHODS:We developed a novel ultrasound system consisting of a modified console and data analysis algorithm. The exploratory study included 100 patients h...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-191047
更新日期：2019-01-01 00:00:00
abstract：:A potassium-doped synthetic apatite was prepared by soaking hydroxyapatite in potassium carbonate and potassium chloride solutions. The hydroxyapatite was prepared by firing slip cast ceramic bodies in vacuum at 1100 degrees C. The conical ceramic samples and a crushed material of this were soaked in carbonate and chl...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVES:Chondrocytes hypertrophy is a physiological process observed in endochondral ossification during development until adolescence in human. It can also be observed during pathophysiological conditions such as osteoarthritis. Hypertrophic chondrocytes synthesise collagen X and express matrix metalloproteinase 13...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141252
更新日期：2015-01-01 00:00:00
abstract：:A number of materials have been considered as sources of grafts to repair bone defects. Here, we examined the possibility of creating in situ-forming gels from sodium carboxymethylcellulose (CMC) and poly(ethyleneimine) (PEI) for use as an in vivo carrier of demineralized bone matrix (DBM). The interaction between ani...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-2009-0603
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:The most common cause of coronary artery disease (CAD) is vascular damage with the cholesterol built-up and other materials on the inner arterial wall, known as atherosclerosis. OBJECTIVE:This paper aims to investigate the effect of stenosis on the hemodynamics in the four suspected coronary artery disease ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-191067
更新日期：2019-01-01 00:00:00
abstract：:The ion selective transport plays an important role in the function of cell membranes, and promotes the application of artificial permeable membranes. This phenomenon has been studied in case for different diameters and functional groups of nanopores. In this work, we focus on the effect of anions on cation selectivit...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130822
更新日期：2014-01-01 00:00:00
abstract：:In the organism epithelia perform perfect barrier functions. Strong rheological and mechanical influences constitute the normal environment of this tissue throughout life. Most epithelia are exposed to different fluids at the luminal and basal sides. To obtain realistic information about tissue development in modern b...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:To establish a method for mouse coronary angiography in vivo using synchrotron radiation, which is essential for physiological and pathological research on coronary diseases. METHODS:1) The imaging parameters (e.g., photon energy, spatial resolution of the detector, and injection rate of contrast agent) optima...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130937
更新日期：2014-01-01 00:00:00
abstract：:In this work, we present an evolutive trabecular model for bone remodeling based on a boundary detection algorithm accounting for both biology and applied mechanical forces, known to be an important factor in bone evolution. A finite element (FE) numerical model using the Abaqus/Standard® software was used with a UMAT...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-171636
更新日期：2017-01-01 00:00:00
