Ultrathin polymer monolayers for promotion of cell growth on bioprosthetic materials -- evolution of a new concept to improve long term performance of biologic heart vales.

Abstract:

:Reoperation of aldehyde tanned bioprotheses due to calcific degeneration remains their major drawback. Based on experiments studying mechanisms and factors that influence the time phase, extent and progression of calcification and evaluating the efficiency of anticalcification treatments and the effects of surface seeding with vital cells a new concept to avoid calcification emerged: masking aldehyde-residues with a covalently bound polymer that supports surface cell seeding. Different covalently bound polymers were tested for their suitability to grow cells. Dense cell growth was achieved on some polymers but without correlation to physico-chemical properties. Ultrathin coating of biological materials appears a promising approach to achieve lining with vital cells.

journal_name

Biomed Mater Eng

authors

Dahm M,Rühe J,Berchthold B,Prüfer D,Prucker O,Chang BJ,Wallrath A,Oelert H

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

419-25

issue

4

eissn

0959-2989

issn

1878-3619

journal_volume

14

pub_type

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