Abstract:
:A number of materials have been considered as sources of grafts to repair bone defects. Here, we examined the possibility of creating in situ-forming gels from sodium carboxymethylcellulose (CMC) and poly(ethyleneimine) (PEI) for use as an in vivo carrier of demineralized bone matrix (DBM). The interaction between anionic CMC and cationic PEI was examined by evaluating phase transition behavior and viscosity of CMC solutions containing 0-30 wt% PEI. CMC solutions containing 10 wt% PEI exhibited a sol-to-gel phase transition at temperatures greater than 35 degrees C. The phase transition is caused by electrostatic crosslinking of the CMC/PEI solution to form a gel with a three-dimensional network structure. In situ-formed gel implants were successfully fabricated in vivo by simple subcutaneous injection of the CMC/PEI (90/10) solution (with and without DBM) into Fisher rats. The resulting in situ-formed implant maintained its shape for 28 days in vitro and in vivo. Our results show that in situ-forming CMC/PEI gels can serve as a DBM carrier that can be delivered with a minimally invasive procedure.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Kim KS,Kang YM,Lee JY,Kim ES,Kim CH,Min BH,Lee HB,Kim JH,Kim MSdoi
10.3233/BME-2009-0603subject
Has Abstractpub_date
2009-01-01 00:00:00pages
381-90issue
6eissn
0959-2989issn
1878-3619pii
W885P270R7452265journal_volume
19pub_type
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