Abstract：
:Gabexate mesilate is a non-peptide protease inhibitor, developed in Japan, which is used in the treatment of acute pancreatitis and disseminated intravascular coagulation. This compound is readily hydrolyzed as it has ester bonds in its structure. It is now out of patent in Japan and there are many generic versions on the market. The crystal structure and the hydrolysate content of the branded product and nine generic versions were evaluated by X-ray diffractometry, thermal analysis and HPLC. The results showed that generic products containing mannitol as an additive had a higher content of hydrolysate as an impurity than the branded product or generic products formulated without mannitol, suggesting that the crystal structure might be altered and stability impaired in mannitol-containing drug products.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Sakurai M,Abe H,Okamura N,Inoue Y,Akiyoshi T,Matsuyama K,Uchida T,Otsuka Mdoi
10.3233/BME-2010-0611subject
Has Abstractpub_date
2010-01-01 00:00:00pages
13-20issue
1eissn
0959-2989issn
1878-3619pii
P414731M405V7340journal_volume
20pub_type
杂志文章abstract：:In this study, design optimization of a tooth implant-supported fixed prosthesis was investigated theoretically. A three-dimensional finite element analysis was utilized to simulate the stress distribution and deformation, with an emphasis on the material selection for various parts of the prosthesis. This mandibular ...
journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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更新日期：1994-01-01 00:00:00
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doi：10.3233/BME-181034
更新日期：2019-01-01 00:00:00
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