Characterization and human osteoblastic proliferation- and differentiation-stimulatory effects of phosphatidylcholine liposomes-encapsulated propranolol hydrochloride.

Abstract:

:DMPC and DSPC liposomes were prepared via thin film hydration method followed by sonication. Propranolol solution was incorporated into liposomes at hydration stage. TEM images showed the sizes of DSPC and DMPC were around 88 and 137 nm, respectively. The highest encapsulation ratio of propranolol was approximately 70% using DSPC/CHO/OCT liposomes, which release the drug over 60% in 24 h and reached 100% in 48 h. Both propranolol (10⁻⁸-10⁻⁶ M) and DSCP liposomes-encapsulated propranolol showed over 1.5-fold increases in the proliferation of human osteoblastic cells hFOB1.19 while differentiation of the cells was approximately doubled by plain and liposomal propranolol, indicating that the stimulatory effects of liposomal propranolol are similar with those of propranolol on human osteoblastic hFOB1.19 cells. The phosphatidylcholine liposomes-encapsulated propranolol prepared in this study potentially possesses anabolic effects in vivo and is also a promising anti-osteoporotic agent in future.

journal_name

Biomed Mater Eng

authors

Teong B,Kuo SM,Chen CH,Chen YK,Cheng ZJ,Huang HH

doi

10.3233/BME-140997

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1875-87

issue

5

eissn

0959-2989

issn

1878-3619

pii

F867541Q141Q3000

journal_volume

24

pub_type

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