Abstract:
:DMPC and DSPC liposomes were prepared via thin film hydration method followed by sonication. Propranolol solution was incorporated into liposomes at hydration stage. TEM images showed the sizes of DSPC and DMPC were around 88 and 137 nm, respectively. The highest encapsulation ratio of propranolol was approximately 70% using DSPC/CHO/OCT liposomes, which release the drug over 60% in 24 h and reached 100% in 48 h. Both propranolol (10⁻⁸-10⁻⁶ M) and DSCP liposomes-encapsulated propranolol showed over 1.5-fold increases in the proliferation of human osteoblastic cells hFOB1.19 while differentiation of the cells was approximately doubled by plain and liposomal propranolol, indicating that the stimulatory effects of liposomal propranolol are similar with those of propranolol on human osteoblastic hFOB1.19 cells. The phosphatidylcholine liposomes-encapsulated propranolol prepared in this study potentially possesses anabolic effects in vivo and is also a promising anti-osteoporotic agent in future.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Teong B,Kuo SM,Chen CH,Chen YK,Cheng ZJ,Huang HHdoi
10.3233/BME-140997subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1875-87issue
5eissn
0959-2989issn
1878-3619pii
F867541Q141Q3000journal_volume
24pub_type
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journal_title:Bio-medical materials and engineering
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