Abstract:
:Most drug delivery systems as treatment modalities for osteomyelitis have not been evaluated for resistant infections. Tigecycline (TG) is an antimicrobial agent that could be used in the treatment of multi-drug-resistant orthopedic infections. The objective of this in vitro study has been to determine what dosage of TG causes changes in the morphology and number of osteoblasts. We have also investigated whether nanoparticulate tigecycline-loaded calcium-phosphate/poly-DL-lactide-co-glycolide is biocompatible and whether it could release bioactive TG in a controlled manner during the observation time. The cytotoxicity was tested by analyzing the release of lactate dehydrogenase from dead osteoblasts to the medium. Staphylococcus aureus was used to verify the antibacterial effect of the multifunctional drug delivery system. At concentrations as achieved by local application, TG caused high toxic effect and impaired the normal osteoblastic morphology. The nanoparticulate multifunctional drug delivery system showed good compatibility and antibacterial effect during the observation time and thus appears to be suitable for the treatment of osteomyelitis caused by multi-drug-resistant microbes.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Ignjatović NL,Ninkov P,Sabetrasekh R,Lyngstadaas SP,Uskoković DPdoi
10.3233/BME-140978subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1647-58issue
4eissn
0959-2989issn
1878-3619pii
G131874J0663X140journal_volume
24pub_type
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