Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) -- structural investigations on two different carrier systems.

Abstract:

:Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectroscopy (PCS). Nanoparticles were characterised by their melting and recrystallisation behaviour recorded by differential scanning calorimetry (DSC). Electron microscope investigations were also carried out showing the particulate character of these carriers. Reasons for observed differences in loading capacity are discussed and possibilities for dermal application are described.

journal_name

Biomed Mater Eng

authors

Saupe A,Wissing SA,Lenk A,Schmidt C,Müller RH

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

393-402

issue

5

eissn

0959-2989

issn

1878-3619

journal_volume

15

pub_type

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