Abstract:
BACKGROUND:Previously we found that a group of phosphorylated proteins (SIBLINGs) in bone binds with the Ti-device, and increases the early bone formation around the Ti-implants remarkably. From these results, we explained the biochemical mechanism of a strong bond between living bone and Ti, which was discovered by Brånemark and colleagues. For the clinical application of our findings, we need a large amount of these proteins or their substitutes. OBJECTIVE:We aimed to create a new molecule that equips with essential functions of SIBLINGs, Ti-binding, and bone enhancement around the Ti implant. METHODS:We chemically phosphorylated chitin and obtained a soluble form of phosphorylated chitin (P-chitin). In this solution, we immersed the Ti-devices of web-form (TW) which we previously developed and obtained the P-chitin coated TWs. Then we tested the P-chitin coated TWs for their calcification ability in vitro, and bone enhancing ability in vivo, by implanting them into rat calvaria. We compared the P-chitin coated TW and the non-coated TW in regard to their calcification and bone enhancing abilities. RESULTS:Ti-devices coated with phosphorylated-chitin induced a ten times higher calcification in vitro at 20 days, and four times more elevated amount of bone formation in vivo at two weeks than the uncoated Ti-device. CONCLUSIONS:Phosphorylated chitin could be a partial substitute of bone SIBLING proteins and are clinically applicable to accelerate bone formation around the Ti implants, thereby achieving the strong bond between living bone and Ti.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Song Q,Yagami K,Furusawa T,Takita H,Kurasaki M,Tokura S,Morimoto K,Sammons R,Iku S,Kuboki Ydoi
10.3233/BME-201079subject
Has Abstractpub_date
2020-01-01 00:00:00pages
47-57issue
1eissn
0959-2989issn
1878-3619pii
BME201079journal_volume
31pub_type
杂志文章abstract::The finite element (FE) method has been widely used to investigate the mechanism of traumatic brain injuries (TBIs), because it is technically difficult to quantify the responses of the brain tissues to the impact in experiments. One of technical challenges to build a FE model of a human head is the modeling of the ce...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171666
更新日期:2017-01-01 00:00:00
abstract::The in vivo and in vitro drug release profiles from a self-setting bioactive CaO-SiO2-P2O5 glass bone cement containing indomethacin as a model drug were investigated. The cement containing 2% and 5% indomethacin (IMC) powder hardened within 5 min after mixing with ammonium phosphate buffer. After setting, in vitro dr...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Intraocular lenses (IOL) made of polymethyl methacrylate (PMMA) lack an important yellowish pigment useful as a filter in the visual process and in the protection of the retina from short wavelength light. It was found that the PMMA used for IOL manufacturing can be tinted by dry exposure to mercury near-UV emitting l...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::This paper presents an X-ray diffraction method of measuring the residual stress/strain in bone tissue of rabbit's tibia. To derive the residual stress, bone powder of the diameter less than 40 micrometers was used as a control specimen at non-stressed state. From the X-ray measurements, it was clear that the distribu...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::In this investigation, ultrasonic parameters of kidney stones are measured, in vitro, using a double probe ultrasonic-through-transmission technique. Due to the complex chemical structure of these stones, a large variation in the values of the ultrasonic parameters is found. A correlation between ultrasonic properties...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Fracture toughness (KIC), critical stress intensity factor, and bending strength of 3 types of commercially available dental composite resins (macrofilled, hybrid and microfilled type) were determined using three point bend specimens. Acoustic Emission (AE), which is the generation of elastic wave due to the release o...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Surface replication is a nondestructive evaluation technique applied in examining surface wear by recording surface irregularities, especially in conditions when surfaces of interest cannot be further manipulated to fit directly under a microscope to be examined. Enamel is the outermost protective layer of t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-206006
更新日期:2020-01-01 00:00:00
abstract::Alginate hydrogels have been used widely in tissue engineering for cell encapsulation for several reasons: low toxicity, the ability to gel under gentle condition and compatibility with cells. In this study, we determined the effect of different concentrations of alginate on encapsulation of 3T3 fibroblast cells at tw...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2011-0665
更新日期:2011-01-01 00:00:00
abstract::Currently, clinicians face choices of restoration including amalgams (mercury-based, gallium-based alloys, or mercury-free silver-based substitutes), composite resins, ceramics, and gold alloy. In order to choose an appropriate restorative material, many parameters are involved; they include preparation time requireme...
journal_title:Bio-medical materials and engineering
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Access to peripheral veins is necessary for sample collection, transfusion and infusion of fluids or medications. The peripheral intravenous catheterization (PIVC) procedure is the introduction of a short catheter into a peripheral vein and can be problematic, leading to multiple failed attempts. PURPOSE:To...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:10.3233/BME-120735
更新日期:2013-01-01 00:00:00
abstract::Electroencephalograph (EEG) signals feature extraction and processing is one of the most difficult and important part in the brain-computer interface (BCI) research field. EEG signals are generally unstable, complex and have low signal-noise ratio, which is difficult to be analyzed and processed. To solve this problem...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141113
更新日期:2014-01-01 00:00:00
abstract::Porous polyethylene (PP or Medpor) is an alloplastic material worldwide used for craniofacial reconstruction. Although several clinical studies are available, there is a lack as regard the genetic effects. Because PP is always fixed on bone and the mechanism by which PP acts on osteoblasts is unknown, we therefore att...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::In this paper, a new method for individual tooth segmentation was proposed. The proposed method is composed of enhancement and extraction of boundary and seed of watershed algorithm using trisection areas by morphological characteristic of teeth. The watershed algorithm is one of the conventional methods for tooth seg...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141153
更新日期:2014-01-01 00:00:00
abstract::Facial nerve paralysis is a common disease due to nerve damage. Most approaches for evaluating the degree of facial paralysis rely on a set of different facial movements as commanded by doctors. Therefore, automatic recognition of the patterns of facial movement is fundamental to the evaluation of the degree of facial...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141093
更新日期:2014-01-01 00:00:00
abstract::Shape memory alloys (SMA) are being increasingly used in various industrial applications as actuators, connectors, or damping materials. In the medical field, superelastic devices such as eyeglass frames, stents or guide catheters have come to market in the recent years. The design of SMA devices has usually been base...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The effect of hydroxyapatite sol (HAm) which is composed of unheating hydroxyapatite microcrystal particle on cell proliferation and alkaline phophatase activity in osteoblastic MC3T3-E1 cells, was examined in the presence or absence of fetal calfe serum (FCS) in the medium. In the absence of FCS, HAm inhibited the ce...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Age is the most important risk factor for primary osteoarthritis (OA). Members of the TGF-β superfamily play a crucial role in chondrocyte differentiation and maintenance of healthy articular cartilage. OBJECTIVE:We have investigated whether age-related changes in TGF-β superfamily signaling components play...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-140976
更新日期:2014-01-01 00:00:00
abstract::Skilled behavior is difficult or impossible to articulate explicitly by the performers. Likewise biomechanical models of skilled motor actions are often limited by the lack of knowledge of the underlying mechanisms. A 'behavioral cloning' technique is described, based on a trained artificial neural network (ANN), that...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Sunscreens that absorb UV light without photodegradation could reduce skin cancer. Polyvinyl silsesquioxanes are known to have greater thermal and photochemical stability than organic compounds, such as those in sunscreens. This paper evaluates the UV transparency of vinyl silsesquioxanes (VS) and its hybrids with SiO...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130853
更新日期:2014-01-01 00:00:00
abstract::We have developed a novel multicomponent nano-hydroxyapatite-poly(D,L-lactide-co-glycolide)-collagen biomaterial (nHAP-PLGA-collagen) with mechanical properties similar to human cancellous bone. To demonstrate the bone forming capacity of nHAP-PLGA-collagen prior to in vivo experiments, nHAP-PLGA-collagen films and 3D...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171703
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Introduction of a new generation of artificial ligaments for ACL reconstruction, the Ligament Augmentation and Reconstruction System (LARS), gives promising clinical results [1]. The current literature supports the use of LARS from short to medium term. To go even further to improve the biocompatibility of t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130753
更新日期:2013-01-01 00:00:00
abstract::A surface plasmon resonance (SPR)-based biosensor was developed for specific detection of nine common respiratory virus, including influenza A and influenza B, H1N1, respiratory syncytial virus (RSV), parainfluenza virus 1-3 (PIV1, 2, 3), adenovirus, and severe acute respiratory syndrome coronavirus (SARS). The SPR bi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151526
更新日期:2015-01-01 00:00:00
abstract::In this study, design optimization of a tooth implant-supported fixed prosthesis was investigated theoretically. A three-dimensional finite element analysis was utilized to simulate the stress distribution and deformation, with an emphasis on the material selection for various parts of the prosthesis. This mandibular ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This study investigates the radiation safety of a newly designed magnetic induction sensor. This novel magnetic induction sensor uses a two-arm Archimedean spiral coil (TAASC) as the exciter. A human head model with a real anatomical structure was used to calculate the specific absorption rate (SAR) and temperature ch...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151329
更新日期:2015-01-01 00:00:00
abstract::Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectr...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Since adhesive technology was introduced into dental field, metal-based restoration has been gradually replaced by metal-free restoration. Using the adhesive technology, minimum invasive technique has been possible in daily clinical practice as well as esthetic tooth-colored restorations have become very popular all o...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:10.3233/BME-2009-0587
更新日期:2009-01-01 00:00:00
abstract::In this work, we present an evolutive trabecular model for bone remodeling based on a boundary detection algorithm accounting for both biology and applied mechanical forces, known to be an important factor in bone evolution. A finite element (FE) numerical model using the Abaqus/Standard® software was used with a UMAT...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171636
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:We aimed to develop a novel ultrasound system and examine its feasibility for noninvasively detecting thoracic aortic aneurysm (TAA) in clinical settings. METHODS:We developed a novel ultrasound system consisting of a modified console and data analysis algorithm. The exploratory study included 100 patients h...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-191047
更新日期:2019-01-01 00:00:00
abstract::Magnesium has attracted a lot of attention as a new class of biodegradable material. The surface properties of magnesium in simulated body fluid (SBF) were investigated in the current research work. Cast magnesium samples with different surface characteristics were prepared which were then placed in SBF for 2, 4 and 8...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-191057
更新日期:2019-01-01 00:00:00
abstract::The selection of stent and balloon type is decisive in the stenting process. In the treatment of an eccentric plaque obstruction, a symmetric expansion from stent dilatation generates nonuniform stress distribution, which may aggravate fibrous cap prone to rupture. This paper developed a new stent design to treat ecce...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-181737
更新日期:2018-01-01 00:00:00