Abstract：
:Porous polyethylene (PP or Medpor) is an alloplastic material worldwide used for craniofacial reconstruction. Although several clinical studies are available, there is a lack as regard the genetic effects. Because PP is always fixed on bone and the mechanism by which PP acts on osteoblasts is unknown, we therefore attempted to address this question by using microRNA microarray techniques to investigate the translation regulation in osteoblasts exposed to PP. The miRNA oligonucleotide microarray provides a novel method to carry out genome-wide microRNA profiling in human samples. By using miRNA microarrays containing 329 probe designed from Human miRNA sequence, we identified in osteoblast-like cells line (MG-63) cultured with Medpor (Porex Corporation, Fairburn, Georgia, USA) several miRNA which expression is significantly modified. We identified 16 up-regulated miRNA (i.e. mir-337, mir-515-3p, mir-377, mir-153, mir-367, mir-152, let-7b, mir-92, mir-155, mir-424, mir-148b, mir-368, mir-18b, mir-520d, mir-20b, mir-128a) and 2 down-regulated miRNA (i.e. mir-143, mir-32). The data reported are, to our knowledge, the first study on translation regulation in osteoblasts exposed to PP. They can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Palmieri A,Pezzetti F,Brunelli G,Martinelli M,Scapoli L,Arlotti M,Masiero E,Carinci Fsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
91-7issue
2eissn
0959-2989issn
1878-3619journal_volume
18pub_type
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
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更新日期：2007-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Bio-medical materials and engineering
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更新日期：1999-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
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journal_title：Bio-medical materials and engineering
pub_type： 历史文章,杂志文章,评审
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更新日期：1996-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
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