Abstract:
:Intensity-Modulated Radiation Therapy (IMRT) mathematically forms a large-scale optimization problem. The development of an IMRT plan is computationally expensive resulting in time-consuming, inefficient, and difficult to develop high-quality IMRT plans. By combining prior knowledge with proposed novel measures derived from both Overlap Volume Histogram (OVH) descriptors and Dose Volume Histograms (DVHs), a novel quality control method for IMRT planning is proposed to assure the high quality of IMRT plan. Clinical approved nasopharyngeal IMRT plans were employed for the experiments, where the reference plan is firstly retrieved from IMRT plan database for each query case by using measures derived from both OVH descriptors and DVHs. Then the DVHs of the reference plan are served as additional goals for the IMRT plan re-optimization. The experimental results show that the proposed method can effectively pick out those IMRT plans, whose quality could be improved substantially (i.e. the doses of their Clinical Targets Volume (CTV) could be effectively increased) and the dose of their Organs at Risk (OARs) could be reduced after the IMRT plan has being re-optimized. In conclusion, the proposed methods can effectively guarantee the high quality of the IMRT planning.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Zhou Z,Chen Y,Yu Z,Wang D,Zhao C,Xu J,Song W,Li B,Shen J,Zhu Xdoi
10.3233/BME-141173subject
Has Abstractpub_date
2014-01-01 00:00:00pages
3479-85issue
6eissn
0959-2989issn
1878-3619pii
VKJ00MQ74K3560K7journal_volume
24pub_type
杂志文章abstract::Poly(propylene fumarate-co-ethylene glycol) random (PPF-1) and block (PPF-2) copolymer oligomers were prepared. Comparing the setting characteristics of PPF-1 and PPF-2 with comonomer n-vinyl pyrrolidone (n-VP) and swelling characteristics of cured PPF-1 and PPF-2, lower setting temperature and setting time was observ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::To better analyze images with the Gaussian white noise, it is necessary to remove the noise before image processing. In this paper, we propose a self-adaptive image denoising method based on bidimensional empirical mode decomposition (BEMD). Firstly, normal probability plot confirms that 2D-IMF of Gaussian white noise...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141143
更新日期:2014-01-01 00:00:00
abstract::Gabexate mesilate is a non-peptide protease inhibitor, developed in Japan, which is used in the treatment of acute pancreatitis and disseminated intravascular coagulation. This compound is readily hydrolyzed as it has ester bonds in its structure. It is now out of patent in Japan and there are many generic versions on...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2010-0611
更新日期:2010-01-01 00:00:00
abstract::The interactions between carbon nanotubes and important biomolecules, above all collagen molecules, have not been studied in detail. This situation is partly due to the fact that CNT are solid entities, while most of the biomolecules can be prepared in solution. We used turbidity as a means of evaluating the interacti...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2009-0557
更新日期:2009-01-01 00:00:00
abstract::Two surface analytical spectroscopic techniques (namely, angular-dependent X-ray photoelectron spectroscopy and static secondary ion mass spectrometry) were used to characterize the nature and composition of the surface and near-surface layers formed on three biomedical polymers (namely, low-density polyethylene, expa...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The aim of the present study was to determine the degradability of aliphatic polyurethanes, based on a different amount of synthetic, atactic poly[(R,S)-3-hydroxybutyrate] (a-PHB), in hydrolytic (phosphate buffer) and oxidative (H2O2/CoCl2) solutions. The soft segments were built with atactic poly[(R,S)-3-hydroxybutyr...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151262
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The simulated Doppler blood flow signals are widely used to assess the performance of the clutter filters for removing wall components while reserving low-velocity signals scattered from physiological blood flow approaching the inner vessel-wall injured by a stenosed lesion. OBJECTIVE:By simultaneously taki...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161573
更新日期:2016-08-12 00:00:00
abstract::In the organism epithelia perform perfect barrier functions. Strong rheological and mechanical influences constitute the normal environment of this tissue throughout life. Most epithelia are exposed to different fluids at the luminal and basal sides. To obtain realistic information about tissue development in modern b...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Currently, clinicians face choices of restoration including amalgams (mercury-based, gallium-based alloys, or mercury-free silver-based substitutes), composite resins, ceramics, and gold alloy. In order to choose an appropriate restorative material, many parameters are involved; they include preparation time requireme...
journal_title:Bio-medical materials and engineering
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::Acrylic resins have been used in many different applications in dentistry, especially in the fabrication of provisional fixed partial dentures. Ideally, a provisional crown and bridge material should be easy to handle and should protect teeth against physical, chemical, and thermal injuries. Some of the problems assoc...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Poly(N-substituted alpha/beta-asparagine) was evaluated as a thermoresponsible and an injectable scaffold for cartilage regeneration. Solutions of this polymer are liquid state below 25 degrees C and nonfluid hydrogel above 35 degrees C, allowing an aqueous solution containing cells at room temperature to form a hydro...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Accelerated hydrothermal aging has long been one of the most widely accepted quality control tests for simulating low-temperature degradation (LTD) in zirconia-containing implants used in total hip arthroplasty (THA). However, it is still unclear how much consistency there is between the experimental predict...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-201083
更新日期:2020-01-01 00:00:00
abstract::The finite element (FE) method has been widely used to investigate the mechanism of traumatic brain injuries (TBIs), because it is technically difficult to quantify the responses of the brain tissues to the impact in experiments. One of technical challenges to build a FE model of a human head is the modeling of the ce...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171666
更新日期:2017-01-01 00:00:00
abstract::We previously reported a simple method for the preparation of size-controlled spherical silver nanoparticles (Ag NPs) generated by autoclaving a mixture of silver-containing glass powder and glucose. The particle size is regulated by the glucose concentration, with concentrations of 0.25, 1.0 and 4.0 wt% glucose provi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130772
更新日期:2013-01-01 00:00:00
abstract::DNA-binding proteins are involved and play a crucial role in a lot of important biological processes. Hence, the identification of the DNA-binding proteins is a challenging and significant problem. In order to reveal the intrinsic information correlated to DNA-binding, nine classes of candidate features based on diffe...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151491
更新日期:2015-01-01 00:00:00
abstract::Microarray data has small samples and high dimension, and it contains a significant amount of irrelevant and redundant genes. This paper proposes a hybrid ensemble method based on double disturbance to improve classification performance. Firstly, original genes are ranked through reliefF algorithm and part of the gene...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151499
更新日期:2015-01-01 00:00:00
abstract::In this study, a computer-aided detection (CAD) system was developed for the detection of lung nodules in computed tomography images. The CAD system consists of four phases, including two-dimensional and three-dimensional preprocessing phases. In the feature extraction phase, four different groups of features are extr...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151418
更新日期:2015-01-01 00:00:00
abstract::Reoperation of aldehyde tanned bioprotheses due to calcific degeneration remains their major drawback. Based on experiments studying mechanisms and factors that influence the time phase, extent and progression of calcification and evaluating the efficiency of anticalcification treatments and the effects of surface see...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti-6Al-4V (3.5-5.3% V; 5.3-6.8% Al; balance -Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory r...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161608
更新日期:2016-01-01 00:00:00
abstract::Various tissue-engineered vascular grafts have been studied in order to overcome the clinical disadvantages associated with conventional prostheses. However, previous tissue-engineered vascular grafts have possessed insufficient mechanical properties and thus have generally required either preoperative cellular manipu...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141023
更新日期:2014-01-01 00:00:00
abstract::We have developed a novel multicomponent nano-hydroxyapatite-poly(D,L-lactide-co-glycolide)-collagen biomaterial (nHAP-PLGA-collagen) with mechanical properties similar to human cancellous bone. To demonstrate the bone forming capacity of nHAP-PLGA-collagen prior to in vivo experiments, nHAP-PLGA-collagen films and 3D...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171703
更新日期:2017-01-01 00:00:00
abstract::Tissue engineering is a multidisciplinary field that applies the principles of engineering, life sciences, cell and molecular biology toward the development of biological substitutes that restore, maintain, and improve tissue function. In Western Countries, tissues or cells management for clinical uses is a medical ac...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2010-0624
更新日期:2010-01-01 00:00:00
abstract::In this study, design optimization of a tooth implant-supported fixed prosthesis was investigated theoretically. A three-dimensional finite element analysis was utilized to simulate the stress distribution and deformation, with an emphasis on the material selection for various parts of the prosthesis. This mandibular ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The objective of the present study was to find a standard substance for use as a reference in the cytotoxicity assay of biomaterials, as an alternative to animal experiments in recent years. Eight kinds of rubber were made in a plate shape to keep their surface area at 1 cm2 against 10 ml of extract volume. They were ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::One goal of functional tissue engineering is to manufacture scaffolds infiltrated with chondrocytes which are suitable for transplantation into the lesion areas of articular cartilage. Various research strategies are used to fabricate cartilage transplants which would have the correct phenotype, contain enough extrace...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::The paper presents an application of the FSI technique to determine hemodynamics in the abdominal aorta (AA). To establish boundary conditions for the FSI study, MR anatomical data and 4D MRI velocity-mapping data (in three blood flow velocity directions and time) were collected to acquire realistic geometry of the AA...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151312
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study is to compare the differences in flexural strength and compressive strength between four resin-modified luting glass ionomer cements that are commonly used in clinics. Furthermore, this study investigates the influence of curing mode on the flexural strength and compressive strength of dual-c...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151284
更新日期:2015-01-01 00:00:00
abstract::This study presents a novel spatial registration method of Image-guided neurosurgery system (IGNS) based on stereo-vision. Images of the patient's head are captured by a video camera, which is calibrated and tracked by an optical tracking system. Then, a set of sparse facial data points are reconstructed from them by ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151391
更新日期:2015-01-01 00:00:00
abstract::Bioelectrical impedance phase angle has been recommended as a tool to assess nutrition state, but there are no measuring devices have been specially designed for hospital residents. In this study, a system was established for the measurement of bioelectrical impedance phase angle. The electrical composition, calculati...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141193
更新日期:2014-01-01 00:00:00
abstract::Sino-atrial node cells (SANCs) play a significant role in rhythmic firing. To investigate their role in arrhythmia and interactions with the atrium, computer simulations based on cellular dynamic mathematical models are generally used. However, the large-scale computation usually makes research difficult, given the li...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151365
更新日期:2015-01-01 00:00:00