Abstract：
:Poly(N-substituted alpha/beta-asparagine) was evaluated as a thermoresponsible and an injectable scaffold for cartilage regeneration. Solutions of this polymer are liquid state below 25 degrees C and nonfluid hydrogel above 35 degrees C, allowing an aqueous solution containing cells at room temperature to form a hydrogel with encapsulated cells at physiological body temperature. Chondrocytes were isolated from joint of 4-week-old Japanese white rabbits, dispersed within the thermoresponsive polymer solution and maintained for up to 72 hours in vitro. The polymer solutions demonstrated concentration-dependent inhibitory effect on chondrocytes multiplication. After the three-day cultivation, the survival rate of the chondrocytes fell into a 70~90% ranges among all the tested polymer concentrations. The morphology studies showed that there were some physical and/or chemical stress leading cells to necrosis and some extent apoptosis. Some physical and/or chemical stress may be applied, and over 70% of the chondrocytes could survive through the stress, suggesting that some phenotype could have been selected from the heterogeneous mixture of chondrocytes.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Chueh SK,Tachibana Y,Uyama H,Kobayashi S,Tomita Nsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
137-46issue
3eissn
0959-2989issn
1878-3619journal_volume
17pub_type
杂志文章abstract：BACKGROUND:The use of helmets was considered to be one of the important prevention strategies employed on construction sites. The shock absorption performance of a construction (or industrial) helmet is its most important performance parameter. Industrial helmets will experience cumulative structural damage when being ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-201132
更新日期：2021-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141103
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:One goal of functional tissue engineering is to manufacture scaffolds infiltrated with chondrocytes which are suitable for transplantation into the lesion areas of articular cartilage. Various research strategies are used to fabricate cartilage transplants which would have the correct phenotype, contain enough extrace...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-206007
更新日期：2020-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
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更新日期：2006-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-2009-0557
更新日期：2009-01-01 00:00:00
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journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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