Abstract：
:The selection of stent and balloon type is decisive in the stenting process. In the treatment of an eccentric plaque obstruction, a symmetric expansion from stent dilatation generates nonuniform stress distribution, which may aggravate fibrous cap prone to rupture. This paper developed a new stent design to treat eccentric plaque using structural transient dynamic analysis in ANSYS. A non-symmetric structural geometry of stent is generated to obtain reasonable stress distribution safe for the arterial layer surrounding the stent. To derive the novel structural geometry, a Sinusoidal stent type is modified by varying struts length and width, adding bridges, and varying curvature width of struts. An end ring of stent struts was also modified to eliminate dogboning phenomenon and to reduce the Ectropion angle. Two balloon types were used to deploy the stent, an ordinary cylindrical and offset balloon. Positive modification results were used to construct the final non-symmetric stent design, called an Asymmetric stent. Analyses of the deformation characteristics, changes in surface roughness and induced stresses within intact arterial layer were subsequently examined. Interaction between the stent and vessel wall was implemented by means of changes in surface roughness and stress distribution analyses. The Palmaz and the Sinusoidal stent were used for a comparative study. This study indicated that the Asymmetric stent types reduced the central radial recoiling and the dogboning phenomenon. In terms of changes in surface roughness and induced stresses, the Asymmetric stent has a comparable effect with that of the Sinusoidal stent. In addition, it could enhance the distribution of surface roughening as expanded by an offset balloon.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Syaifudin A,Takeda R,Sasaki Kdoi
10.3233/BME-181737subject
Has Abstractpub_date
2018-01-01 00:00:00pages
299-317issue
3eissn
0959-2989issn
1878-3619pii
BME1737journal_volume
29pub_type
杂志文章abstract：BACKGROUND:Stenting has been proposed as an effective treatment to restore blood flow in obstructed arteries by plaques. Although several modified designs for stents have been suggested, most designs have the risk of disturbing blood flow. OBJECTIVE:The main objective is to propose a stent design to attain a uniform l...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-171691
更新日期：2017-01-01 00:00:00
abstract：UNLABELLED:It is suggested that nanophase hydroxyapatite (nHAP) might have advantages over conventional hydroxyapatite (cHAP) as a biomaterial for bone regeneration. To be a satisfactory candidate for bone tissue engineering, it is important to support the growth and differentiation of bone marrow-derived mesenchymal s...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Cuff electrodes have been widely used chronically in different clinical applications. Advancements have been made in selective stimulation by using multi-contact cuff electrodes. Steering anodic current is a strategy to increase selectivity by reshaping and localizing electric fields. There are two configura...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151281
更新日期：2015-01-01 00:00:00
abstract：:Commercially pure titanium (CPT) substrate was subjected to porcelain firing and bond strengths under three-point bending mode (span length: 15 mm; crosshead speed: 0.5 mm/min) were evaluated. Experimental variables included surface treatments of CPT and porcelain firing schedules. Variables for the surface treatments...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Age-related macular degeneration (ARMD) and intraocular neovascular diseases have been treated clinically by anti-VEGF antibody drug bevacizumab. However, the use of bevacizumab in the treatment of retinal neovascular diseases has been limited due to the short half-life and frequent injections. In this research, novel...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141003
更新日期：2014-01-01 00:00:00
abstract：:The stability of the Co-Cr-Mo dental alloy immersed in artificial salivas (pH 6.7) was investigated over 24 h. Three artificial salivas have been studied: saline saliva (saliva I); saline saliva buffered with phosphate ions (saliva II) and saliva II plus mucin molecules (saliva III). For all the systems, open circuit ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141241
更新日期：2015-01-01 00:00:00
abstract：:Numerous constitutive models describing the mechanical properties of tendons have been proposed during the past few decades. However, few were widely used owing to the lack of implementation in the general finite element (FE) software, and very few systematic studies have been done on selecting the most appropriate pa...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-2011-0653
更新日期：2011-01-01 00:00:00
abstract：:Milkvetch root as a medicine has been used for more over 2000 years in China, can strengthen immune function, protect liver, promote urination, resist aging and stress, reduce blood pressure and extensively resist bacterium. This study explored the effects of milkvetch root on the immune function of patients with a de...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章,随机对照试验
doi：10.3233/BME-151517
更新日期：2015-01-01 00:00:00
abstract：:Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectr...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:A crucial role during the implementation of volume visualization is to identify the optimal transfer function, since the vital information and structure can be highlighted and revealed. The boundary of the volume is shared by respective portion of the two materials formed out of it, which causes undesirable thickening...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141123
更新日期：2014-01-01 00:00:00
abstract：:In a previous work by the author [H.S. Hedia and M. Nemat-Alla, Design optimization of functionally graded dental implant, submitted to be published in the J. Bio-Medical Materials and Engineering], a functionally graded material dental implant was designed without cansellous bone in the model. In this investigation t...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Fracture toughness (KIC), critical stress intensity factor, and bending strength of 3 types of commercially available dental composite resins (macrofilled, hybrid and microfilled type) were determined using three point bend specimens. Acoustic Emission (AE), which is the generation of elastic wave due to the release o...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are a common tool in regenerative medicine. The nanoscale extracellular vesicles (nEVs) secreted by these cells were recently brought up to light thanks to their therapeutic potential. In this study, we assessed the in vitro behaviour of human umbilical vein endothelial cells (HUVECs) exp...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-171626
更新日期：2017-01-01 00:00:00
abstract：:To investigate the inhibition effect of oxymatrine induces human lung cancer A549 cells apoptosis. The A549 cells were cultured for 24 h, than the various concentration of oxymatrine (2 mmol/L, 4 mmol/L, 8 mmol/L, 15 mmol/L) were added into different experimental group cells, and 5-fluorouracil were added into the pos...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151302
更新日期：2015-01-01 00:00:00
abstract：:To evaluate the ability of assessing the refractive change induced by myopic laser surgery using the intrinsic data, obtained from a reference intrinsic to the cornea. Twenty-nine eyes with laser in situ keratomileusis for myopia were included in the study. Statistical analyses were performed to determine the relation...
journal_title：Bio-medical materials and engineering
pub_type： 临床试验,杂志文章
doi：10.3233/BME-151374
更新日期：2015-01-01 00:00:00
abstract：:In this second part of the series of reviews, attention focuses on analytical and numerical methods that have been used to estimate the magnitude of the contact stress in: models of articular joints; models of total joint replacements, without and with the associated joint; or models of simple physical systems that ar...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:High order partial least squares (HOPLS) is a novel data processing method. It is highly suitable for building prediction model which has tensor input and output. The objective of this study is to build a prediction model of the relationship between sinoatrial node field potential and high glucose using HOPLS. The thr...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151482
更新日期：2015-01-01 00:00:00
abstract：:Poly(propylene fumarate-co-ethylene glycol) random (PPF-1) and block (PPF-2) copolymer oligomers were prepared. Comparing the setting characteristics of PPF-1 and PPF-2 with comonomer n-vinyl pyrrolidone (n-VP) and swelling characteristics of cured PPF-1 and PPF-2, lower setting temperature and setting time was observ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:A robust method for inducing bone-formation without an autograft has not been established. Currently, both platelet-rich plasma (PRP) and bone morphogenetic protein (BMP) have been widely investigated for their clinical use in such cases. However, their synergistic effect is still controversial and previously shown di...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130741
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Electrospinning is a highly effective method in order to generate nano-scaled fibers. In conventional electrospinning technique, geometry of nanofibers are mostly random due to the chaotic behavior of polymer jet. OBJECTIVE:Purpose of this study is to produce aligned nanofibers from PVP polymers with advanc...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-181017
更新日期：2018-01-01 00:00:00
abstract：:Fifty two ceramic femoral heads have been investigated after implantation. All heads had articulated against ultra high molecular weight polyethylene (UHMWPE) cups. Examination of the heads shows changes in sphericity and surface roughness due to the wear. The behaviour of these retrieved heads after clinical use conf...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Three patterned systems aiming at the control of mammalian cell behavior are presented. The determinant feature common to these systems is the spatial distribution of extracellular matrix (ECM) proteins (mainly collagen) on polymer substrates. This distribution differs from one system to another with respect to the sc...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:DNA-binding proteins are involved and play a crucial role in a lot of important biological processes. Hence, the identification of the DNA-binding proteins is a challenging and significant problem. In order to reveal the intrinsic information correlated to DNA-binding, nine classes of candidate features based on diffe...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151491
更新日期：2015-01-01 00:00:00
abstract：:Level set method has been widely used in medical image analysis, but it has difficulties when being used in the segmentation of left ventricular (LV) boundaries on echocardiography images because the boundaries are not very distinguish, and the signal-to-noise ratio of echocardiography images is not very high. In this...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151427
更新日期：2015-01-01 00:00:00
abstract：:A double-layered tube consisting of a porous inner tube and a solid outer tube was used to perfuse isotonic saline solution into blood to prevent blood cell adhesion. Polystyrene/poly(styrene-co-butadiene) (PS-SBR) porous tubes were made using a dipping method. Citrated canine blood was circulated for 30 min with the ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Dry emulsion containing curcumin (DE-CUR) was prepared for oral delivery of poorly water-soluble curcumin, and its oral bioavailability and antiasthmatic efficacy was evaluated. After comparison of the solubility of curcumin in various oils, Plurol® Oleique CC497 was selected to be the oil phase due to its higher solu...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130886
更新日期：2014-01-01 00:00:00
abstract：:Recognition of lung cancer cells is very important to the clinical diagnosis of lung cancer. In this paper we present a novel method to extract the structure characteristics of lung cancer cells and automatically recognize their types. Firstly soft mathematical morphology methods are used to enhance the grayscale imag...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:We previously reported a simple method for the preparation of size-controlled spherical silver nanoparticles (Ag NPs) generated by autoclaving a mixture of silver-containing glass powder and glucose. The particle size is regulated by the glucose concentration, with concentrations of 0.25, 1.0 and 4.0 wt% glucose provi...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130772
更新日期：2013-01-01 00:00:00
abstract：:The bonding strength of porcelains to metals depends on the oxide layer between the porcelain and the metal. Oxidation of a metal surface increases the bonding strength, whereas excessive oxidation decreases it. Titanium and its alloys are gaining acceptance for dental use since they exhibit excellent biocompatibility...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Low-dose computed tomography reconstruction is an important issue in the medical imaging domain. Sparse-view has been widely studied as a potential strategy. Compressed sensing (CS) method has shown great potential to reconstruct high-quality CT images from sparse-view projection data. Nonetheless, low-contrast struct...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151437
更新日期：2015-01-01 00:00:00
