Abstract:
:We previously reported a simple method for the preparation of size-controlled spherical silver nanoparticles (Ag NPs) generated by autoclaving a mixture of silver-containing glass powder and glucose. The particle size is regulated by the glucose concentration, with concentrations of 0.25, 1.0 and 4.0 wt% glucose providing small (3.48 ± 1.83 nm in diameter), medium (6.53 ± 1.78 nm) and large (12.9 ± 2.5 nm) particles, respectively. In this study, Ag NP/chitosan composites were synthesized by mixing each of these three Ag NP suspensions with a 75% deacetylated (DAc) chitosan suspension (pH 5.0) at room temperature. The Ag NPs were homogeneously dispersed and stably embedded in the chitosan matrices. The Ag NP/chitosan composites were obtained as yellow or brown flocs. It was estimated that approximately 60, 120 and 360 μg of the small, medium and large Ag NPs, respectively, were maximally embedded in 1 mg of chitosan. The bactericidal and anti-fungal activities of the Ag NP/chitosan composites increased as the amount of Ag NPs in the chitosan matrix increased. Furthermore, smaller Ag NPs (per weight) in the chitosan composites provided higher bactericidal and anti-fungal activities.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Nguyen VQ,Ishihara M,Mori Y,Nakamura S,Kishimoto S,Fujita M,Hattori H,Kanatani Y,Ono T,Miyahira Y,Matsui Tdoi
10.3233/BME-130772subject
Has Abstractpub_date
2013-01-01 00:00:00pages
473-83issue
6eissn
0959-2989issn
1878-3619pii
980N05U0XNH27155journal_volume
23pub_type
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