Enhanced oral bioavailability and antiasthmatic efficacy of curcumin using redispersible dry emulsion.

Abstract:

:Dry emulsion containing curcumin (DE-CUR) was prepared for oral delivery of poorly water-soluble curcumin, and its oral bioavailability and antiasthmatic efficacy was evaluated. After comparison of the solubility of curcumin in various oils, Plurol® Oleique CC497 was selected to be the oil phase due to its higher solubility of CUR than other oils. A dry emulsion prepared by spray-drying of a homogenized oil-in-water emulsion was well-reconstituted in water, fabricating similar particle distribution and in vitro release to that of a dispersed homogeneous emulsion before spraying. The release of DE-CUR was much higher than that of curcumin (85.3 vs. 1.7% release at 60 min). Consequently, DE-CUR resulted in 12.0- and 7.1-fold higher Cmax and AUC0-24h than curcumin. In a murine asthma model, DE-CUR effectively suppressed airway hyperresponsiveness and levels of T-helper cytokines such as interleukin-4, inteleukin-5, and interleukin-13. These findings demonstrate that the DE-CUR shows a potential for the development of functional foods or medicines including CUR.

journal_name

Biomed Mater Eng

authors

Jang DJ,Kim ST,Oh E,Lee K

doi

10.3233/BME-130886

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

917-30

issue

1

eissn

0959-2989

issn

1878-3619

pii

C633072VP8271704

journal_volume

24

pub_type

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