Abstract:
:In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S. Eight weeks later, Van Gieson staining was used to observe pathological changes, and basic hydrolysis methods were adopted to measure hydroxyproline content, while Western Blot was used to determine the expression of MMP2, MMP7, MMP11, MMP13, MMP16, TIMP1 and TGFβ1.The results showed that significant myocardial fibrosis, decreased TIMP1 and MMP2 expression and increased MMP7, MMP11, MMP13, MMP16 expressions occurred in diabetic group, but all these changes were significantly reversed in diabetic rats after NaHS treatment. This suggests that H2S could attenuate cardiac fibrosis induced by diabetes and its mechanisms may be related to its modulation of MMPs/TIMPs expression and regulation of TGFβ1.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Xiao T,Zeng O,Luo J,Wu Z,Li F,Yang Jdoi
10.3233/BME-151508subject
Has Abstractpub_date
2015-01-01 00:00:00pages
S2033-9eissn
0959-2989issn
1878-3619pii
BME1508journal_volume
26 Suppl 1pub_type
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-201103
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141113
更新日期:2014-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
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更新日期:2018-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130897
更新日期:2014-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141063
更新日期:2014-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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更新日期:1991-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
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更新日期:2007-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
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doi:10.3233/BME-130791
更新日期:2014-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171626
更新日期:2017-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2014-01-01 00:00:00