Abstract:
:The cilia, presenting a rotational movement in the embryonic nodes, play a crucial role in the left-right specification during embryogenesis. The characteristic architecture of these cilia is based on a cylindrical arrangement of 9 doublet microtubules and the motion of the cilia is triggered by the dynein motors located between adjacent doublets by converting the chemical energy into mechanical work. Restricted by the inherent difficulties of experiments, the dynein activation patterns in moving cilia cannot be directly observed. Thus, the mechanism of nodal ciliary movement is still unclear. In this study, we present computational models of the nodal ciliary ultrastructure based on tomographic images of the ciliary body. By employing time accurate three-dimensional solid mechanics analysis, we investigate the dynein-triggered sliding between adjacent doublet microtubules and simulate the induced ciliary bending. As an exploratory study, two dynein activation patterns are proposed and their rationality is discussed. The mathematical model presented by this paper provides a platform to investigate various assumptions of dynein activity, facilitating us to propose the most possible dynein activation pattern and therefore improving our understandings regarding the protein-beating problems of cilia.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Chen D,Zhong Y,Shinohara K,Nishida T,Hasegawa T,Hamada Hdoi
10.3233/BME-141063subject
Has Abstractpub_date
2014-01-01 00:00:00pages
2495-501issue
6eissn
0959-2989issn
1878-3619pii
W517J202N7H84432journal_volume
24pub_type
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3233/BME-141203
更新日期:2014-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151508
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3233/BME-180999
更新日期:2018-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-171666
更新日期:2017-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-201079
更新日期:2020-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,随机对照试验
doi:10.3233/BME-151517
更新日期:2015-01-01 00:00:00
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doi:10.3233/BME-161608
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journal_title:Bio-medical materials and engineering
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doi:10.3233/BME-2009-0603
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journal_title:Bio-medical materials and engineering
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141083
更新日期:2014-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
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journal_title:Bio-medical materials and engineering
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更新日期:1997-01-01 00:00:00
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