Abstract：
:The biological, biochemical, mechanical, and structural properties of artificial scaffolds for tissue engineering are known to be of great importance. Therefore, in this study a hydrogel derived scaffold with biomechanical and structural properties similar to native articular cartilage was synthesized. The gelatine-based hydrogel was processed by freeze-structuring, structuring by electrochemical water-decomposition, freeze-drying and chemical fixation resulting in a defined scaffold-structure. By electron microscopy a perpendicular pore-channel structure was verified with channel diameters between 30 microm and 70 microm. Mechanical testing showed mechanical properties similar to native cartilage. Human chondrocytes from biopsy samples were cultivated on these hydrogel scaffolds for three days. Two different cell densities (1.2 x 10(6) cells/cm3 and 12.0 x 10(6) cells/cm3) were used for cultivation. Histology of the cell seeded artificial scaffolds demonstrated vital cells that are widely distributed within the scaffold and mimic a columnar arrangement.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Zehbe R,Libera J,Gross U,Schubert Hsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
445-54issue
6eissn
0959-2989issn
1878-3619journal_volume
15pub_type
杂志文章abstract：:The in vivo and in vitro drug release profiles from a self-setting bioactive CaO-SiO2-P2O5 glass bone cement containing indomethacin as a model drug were investigated. The cement containing 2% and 5% indomethacin (IMC) powder hardened within 5 min after mixing with ammonium phosphate buffer. After setting, in vitro dr...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In this study, biocompatibility of 17-4 PH stainless steel foam for biomedical implant applications was investigated. 17-4 PH stainless steel foams having porosities in the range of 40-82% with an average pore size of around 600 μm were produced by space holder-sintering technique. Sintered foams were precipitation ha...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-2011-0671
更新日期：2011-01-01 00:00:00
abstract：:In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S. Eight weeks later, Van Gieson st...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-151508
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Surface replication is a nondestructive evaluation technique applied in examining surface wear by recording surface irregularities, especially in conditions when surfaces of interest cannot be further manipulated to fit directly under a microscope to be examined. Enamel is the outermost protective layer of t...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-206006
更新日期：2020-01-01 00:00:00
abstract：:Using a wet method, we have synthesized octacalcium phosphate carbonate, in which HPO42- in octacalcium phosphate is replaced with CO32-. The physical, crystal, and chemical properties of this new material were compared to octacalcium phosphate, Ca-deficient hydroxyapatite, and Ca-deficient carbonate apatite using X-r...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-171651
更新日期：2017-01-01 00:00:00
abstract：:Three patterned systems aiming at the control of mammalian cell behavior are presented. The determinant feature common to these systems is the spatial distribution of extracellular matrix (ECM) proteins (mainly collagen) on polymer substrates. This distribution differs from one system to another with respect to the sc...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Correlation-based feature selection (CFS) using neighborhood mutual information (NMI) and particle swarm optimization (PSO) are combined into an ensemble technique in this paper. Based on this observation, an efficient gene selection algorithm, denoted by NMICFS-PSO, is proposed. Several cancer recognition tasks are g...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130897
更新日期：2014-01-01 00:00:00
abstract：:Hydroxyapatite was coated with 1 microm thickness on titanium columns of a length of 10 mm, an outer diameter of 4.0 mm by radio frequency magnetron sputtering. The hydroxyapatite coating titanium columns were implanted in the diaphysis of femora of 3 adult dogs, and push-out test was carried out after 2, 4 and 12 wee...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Hyaluronic acid (HA) was used as an internal phase additive to improve the loading efficiency of ofloxacin, a hydrophilic drug encapsulated by hydrophobic polylactic-co-glycolic acid (PLGA) materials, through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Results from laser distributi...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130863
更新日期：2014-01-01 00:00:00
abstract：:In this paper, a new method for individual tooth segmentation was proposed. The proposed method is composed of enhancement and extraction of boundary and seed of watershed algorithm using trisection areas by morphological characteristic of teeth. The watershed algorithm is one of the conventional methods for tooth seg...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141153
更新日期：2014-01-01 00:00:00
abstract：:The effect of hydroxyapatite sol (HAm) which is composed of unheating hydroxyapatite microcrystal particle on cell proliferation and alkaline phophatase activity in osteoblastic MC3T3-E1 cells, was examined in the presence or absence of fetal calfe serum (FCS) in the medium. In the absence of FCS, HAm inhibited the ce...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:A number of materials have been considered as sources of grafts to repair bone defects. Here, we examined the possibility of creating in situ-forming gels from sodium carboxymethylcellulose (CMC) and poly(ethyleneimine) (PEI) for use as an in vivo carrier of demineralized bone matrix (DBM). The interaction between ani...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-2009-0603
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Adipose tissue engineering has been studied as an alternative to current options for breast reconstruction, such as lipofilling, flap reconstruction, and silicone implants. Previously, we demonstrated that a poly(L-lactic acid) mesh containing a collagen sponge, containing neither cells nor growth factors, c...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-201103
更新日期：2020-01-01 00:00:00
abstract：:The cilia, presenting a rotational movement in the embryonic nodes, play a crucial role in the left-right specification during embryogenesis. The characteristic architecture of these cilia is based on a cylindrical arrangement of 9 doublet microtubules and the motion of the cilia is triggered by the dynein motors loca...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141063
更新日期：2014-01-01 00:00:00
abstract：:Aqueous poly(vinyl alcohol) solutions were frozen at -20 degrees C for 6-12 h, and subsequently thawed for 1-2 h. The above mentioned process repeated for 1-3 times. After the specimen was dehydrated in vacuum, a kind of artificial articular cartilage--PVA-hydrogel--was developed. The micromorphology of PVA-hydrogel h...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Skilled behavior is difficult or impossible to articulate explicitly by the performers. Likewise biomechanical models of skilled motor actions are often limited by the lack of knowledge of the underlying mechanisms. A 'behavioral cloning' technique is described, based on a trained artificial neural network (ANN), that...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Currently, clinicians face choices of restoration including amalgams (mercury-based, gallium-based alloys, or mercury-free silver-based substitutes), composite resins, ceramics, and gold alloy. In order to choose an appropriate restorative material, many parameters are involved; they include preparation time requireme...
journal_title：Bio-medical materials and engineering
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:In this investigation, ultrasonic parameters of kidney stones are measured, in vitro, using a double probe ultrasonic-through-transmission technique. Due to the complex chemical structure of these stones, a large variation in the values of the ultrasonic parameters is found. A correlation between ultrasonic properties...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:In order to investigate the significance of hydroxyapatite based microporous composite (HA/mica composite) surfaces and a macroporous synthetic hydroxyapatite, rat marrow cell culture, which shows osteogenic differentiation, was carried out on six different culture substrata (two control culture dishes, two identical ...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Introduction of a new generation of artificial ligaments for ACL reconstruction, the Ligament Augmentation and Reconstruction System (LARS), gives promising clinical results [1]. The current literature supports the use of LARS from short to medium term. To go even further to improve the biocompatibility of t...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-130753
更新日期：2013-01-01 00:00:00
abstract：:Recognition of lung cancer cells is very important to the clinical diagnosis of lung cancer. In this paper we present a novel method to extract the structure characteristics of lung cancer cells and automatically recognize their types. Firstly soft mathematical morphology methods are used to enhance the grayscale imag...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Some computer applications for cell characterization in medicine and biology, such as analysis of surface structure of cell wall-deficient EVC (El Tor Vibrio of Cholera), operate with cell samples taken from very small areas of interest. In order to perform texture characterization in such an application, only a few t...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Various tissue-engineered vascular grafts have been studied in order to overcome the clinical disadvantages associated with conventional prostheses. However, previous tissue-engineered vascular grafts have possessed insufficient mechanical properties and thus have generally required either preoperative cellular manipu...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141023
更新日期：2014-01-01 00:00:00
abstract：:Acrylic resins have been used in many different applications in dentistry, especially in the fabrication of provisional fixed partial dentures. Ideally, a provisional crown and bridge material should be easy to handle and should protect teeth against physical, chemical, and thermal injuries. Some of the problems assoc...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Platelet-rich plasma (PRP) has been used to solubilize freeze-dried chitosan (CS) formulations to form injectable implants for tissue repair. OBJECTIVE:To determine whether the in vitro performance of the formulations depends on the type of PRP preparation used to solubilize CS. METHODS:Formulations contai...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-191058
更新日期：2019-01-01 00:00:00
abstract：:Hydroxyapatite is widely utilized as a component in dental hygiene agents. The ability to adsorb and remove dental plaque adhering to tooth surfaces is recognized as an important property of hydroxyapatite particles. In this study, the adsorptive ability of hydroxyapatite was evaluated based on its adsorptive amount a...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To study the comprehensive biomechanical properties of the cancellous bone of distal femur through a series of mechanical tests, and provide relevant subjects with the basic technical data. BACKGROUND:The study on bone mechanics is a commonly used approach to evaluate the biomechanical competency of bone. Th...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Poly(N-substituted alpha/beta-asparagine) was evaluated as a thermoresponsible and an injectable scaffold for cartilage regeneration. Solutions of this polymer are liquid state below 25 degrees C and nonfluid hydrogel above 35 degrees C, allowing an aqueous solution containing cells at room temperature to form a hydro...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Age-related macular degeneration (ARMD) and intraocular neovascular diseases have been treated clinically by anti-VEGF antibody drug bevacizumab. However, the use of bevacizumab in the treatment of retinal neovascular diseases has been limited due to the short half-life and frequent injections. In this research, novel...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：10.3233/BME-141003
更新日期：2014-01-01 00:00:00
abstract：:Local strains acting across an area of skin loaded uniaxially in vivo are converted to stresses using the standard elastic formulae. The stress values are compared to those obtained using the classical Bossinesq and Michell stress functions. The results indicate that these functions are capable of describing the respo...
journal_title：Bio-medical materials and engineering
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
