Abstract:
:Hyaluronic acid (HA) was used as an internal phase additive to improve the loading efficiency of ofloxacin, a hydrophilic drug encapsulated by hydrophobic polylactic-co-glycolic acid (PLGA) materials, through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Results from laser distribution analysis show that polyelectrolyte additives have low impact on the average particle size and distribution of the microspheres. The negatively charged HA increases the drug loading efficiency as well as the amount of HA in microspheres. Burst release can be observed in the groups with the polyelectrolyte additives. The release rate decreases with the amount of HA inside the microspheres in all negatively charged polyelectrolyte-added microsphere groups.
journal_name
Biomed Mater Engjournal_title
Bio-medical materials and engineeringauthors
Wu G,Chen L,Li H,Wang YJdoi
10.3233/BME-130863subject
Has Abstractpub_date
2014-01-01 00:00:00pages
751-6issue
1eissn
0959-2989issn
1878-3619pii
A5G380P38011K314journal_volume
24pub_type
杂志文章abstract::Shape memory alloys (SMA) are being increasingly used in various industrial applications as actuators, connectors, or damping materials. In the medical field, superelastic devices such as eyeglass frames, stents or guide catheters have come to market in the recent years. The design of SMA devices has usually been base...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The current density of Ti-56mass%Ni (Ti-50at.%) alloy after abrasion in simulated bioliquids was measured using a potentiostat to estimate the amount of metallic ions released from the alloy during repassivation and maturation. The current density in saline, saline with and without N2 bubbling, and Hanks' solutions wi...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::A potassium-doped synthetic apatite was prepared by soaking hydroxyapatite in potassium carbonate and potassium chloride solutions. The hydroxyapatite was prepared by firing slip cast ceramic bodies in vacuum at 1100 degrees C. The conical ceramic samples and a crushed material of this were soaked in carbonate and chl...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::The objective of this study is to evaluate whether the accumulation model developed by Zarfl et al. (2008) could be used to predict the minimal inhibitory concentration (MIC) of a group of antibacterial fluoroquinolones (FQs) for Escherichia coli (E. coli). Our model, which is based on the "Fick-Nernst-Planck" equatio...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141203
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Cuff electrodes have been widely used chronically in different clinical applications. Advancements have been made in selective stimulation by using multi-contact cuff electrodes. Steering anodic current is a strategy to increase selectivity by reshaping and localizing electric fields. There are two configura...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151281
更新日期:2015-01-01 00:00:00
abstract::Synthetic grafting materials, such as calcium phosphates (hydroxyapatite, HA; tricalcium phosphate, TCP), polymers, or composites thereof, can be used as osteoconductive scaffolds and delivery vehicles for osteoinductive growth factors. Carrier materials must be engineered to deliver these factors in a controlled fash...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Polycrystalline diamond (PCD) exhibits excellent abrasive characteristics and is commonly used as loose grains for precision machining of hard ceramics and other materials that are difficult to grind and polish. In the present study, we investigated using bonded PCD for polishing dental porcelain, for which a lustrous...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2010-0642
更新日期:2010-01-01 00:00:00
abstract::In this investigation, ultrasonic parameters of kidney stones are measured, in vitro, using a double probe ultrasonic-through-transmission technique. Due to the complex chemical structure of these stones, a large variation in the values of the ultrasonic parameters is found. A correlation between ultrasonic properties...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract:PURPOSE:To establish a method for mouse coronary angiography in vivo using synchrotron radiation, which is essential for physiological and pathological research on coronary diseases. METHODS:1) The imaging parameters (e.g., photon energy, spatial resolution of the detector, and injection rate of contrast agent) optima...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130937
更新日期:2014-01-01 00:00:00
abstract::Aqueous poly(vinyl alcohol) solutions were frozen at -20 degrees C for 6-12 h, and subsequently thawed for 1-2 h. The above mentioned process repeated for 1-3 times. After the specimen was dehydrated in vacuum, a kind of artificial articular cartilage--PVA-hydrogel--was developed. The micromorphology of PVA-hydrogel h...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::A robust method for inducing bone-formation without an autograft has not been established. Currently, both platelet-rich plasma (PRP) and bone morphogenetic protein (BMP) have been widely investigated for their clinical use in such cases. However, their synergistic effect is still controversial and previously shown di...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130741
更新日期:2013-01-01 00:00:00
abstract::Sepsis is a systemic inflammatory response syndrome with high mortality, which results from severe infection and can lead to secondary organ dysfunction. It is one of the most common cause of death in intensive care unit. Clinical reports have shown that sepsis was often accompanied by thyroid dysfunction, which is ca...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章,评审
doi:10.3233/BME-171646
更新日期:2017-01-01 00:00:00
abstract::Poly(propylene fumarate-co-ethylene glycol) random (PPF-1) and block (PPF-2) copolymer oligomers were prepared. Comparing the setting characteristics of PPF-1 and PPF-2 with comonomer n-vinyl pyrrolidone (n-VP) and swelling characteristics of cured PPF-1 and PPF-2, lower setting temperature and setting time was observ...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Metal patch test is often used in clinical settings when metal-induced contact dermatitis is suspected. However, the transdermal permeation behavior of metal ions from the patch test remains unclear. Current patch tests using high concentrations of metal salt solutions have some side effects, e.g. acute skin reactions...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151543
更新日期:2015-01-01 00:00:00
abstract::Significant progress has been achieved in the field of pH-sensitive drug delivery system in recent years. For layer-by-layer self-assembly nanocarriers, various pH values can induce the change of permeability and structural stability of the outer polyelectrolyte multi-layers, resulting in the release of the loaded dru...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141033
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Introduction of a new generation of artificial ligaments for ACL reconstruction, the Ligament Augmentation and Reconstruction System (LARS), gives promising clinical results [1]. The current literature supports the use of LARS from short to medium term. To go even further to improve the biocompatibility of t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130753
更新日期:2013-01-01 00:00:00
abstract::Some computer applications for cell characterization in medicine and biology, such as analysis of surface structure of cell wall-deficient EVC (El Tor Vibrio of Cholera), operate with cell samples taken from very small areas of interest. In order to perform texture characterization in such an application, only a few t...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The thrust of the present work is the demonstration of the feasibility of using an enzyme-linked immunosorbent assay (ELISA) for the detection and quantification of a monoclonal antibody human serum. The antibodies used, 7E3 and D3GP3, have been proposed as platelet receptor blockers, being directed specifically again...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Correlation-based feature selection (CFS) using neighborhood mutual information (NMI) and particle swarm optimization (PSO) are combined into an ensemble technique in this paper. Based on this observation, an efficient gene selection algorithm, denoted by NMICFS-PSO, is proposed. Several cancer recognition tasks are g...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-130897
更新日期:2014-01-01 00:00:00
abstract::The interactions between carbon nanotubes and important biomolecules, above all collagen molecules, have not been studied in detail. This situation is partly due to the fact that CNT are solid entities, while most of the biomolecules can be prepared in solution. We used turbidity as a means of evaluating the interacti...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2009-0557
更新日期:2009-01-01 00:00:00
abstract::In recent years, there is an increasing utilization and demand to use magnetic fields in bioengineering applications due to its beneficial effects. Although in the last decade more attention has been given by tribologists to the electromagnetic processes taking place between sliding surfaces, which influence the tribo...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Patients use mouthwashes in addition to mechanical cleaning during orthodontic treatment. The effects of mouthwashes on the archwires have not been examined yet. OBJECTIVE:To compare the corrosion resistance of four different arch wires and corrosion effects of different mouthwashes to formulate a biocompat...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161607
更新日期:2016-11-25 00:00:00
abstract::In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S. Eight weeks later, Van Gieson st...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-151508
更新日期:2015-01-01 00:00:00
abstract::Chimerism analysis has become an important tool to manage patients in the peri-transplant period of allogenic stem cell transplantation. During this period, cells of donor and host origin can coexist and increasing proportion of cells of host origin is considered as a recurrence of the underlying disease. We currently...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::This paper presents an X-ray diffraction method of measuring the residual stress/strain in bone tissue of rabbit's tibia. To derive the residual stress, bone powder of the diameter less than 40 micrometers was used as a control specimen at non-stressed state. From the X-ray measurements, it was clear that the distribu...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Commercially pure titanium (CPT) substrate was subjected to porcelain firing and bond strengths under three-point bending mode (span length: 15 mm; crosshead speed: 0.5 mm/min) were evaluated. Experimental variables included surface treatments of CPT and porcelain firing schedules. Variables for the surface treatments...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Numerous constitutive models describing the mechanical properties of tendons have been proposed during the past few decades. However, few were widely used owing to the lack of implementation in the general finite element (FE) software, and very few systematic studies have been done on selecting the most appropriate pa...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-2011-0653
更新日期:2011-01-01 00:00:00
abstract::The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti-6Al-4V (3.5-5.3% V; 5.3-6.8% Al; balance -Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory r...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-161608
更新日期:2016-01-01 00:00:00
abstract::Robotized endoscope holder in laparoscopic surgeries allows surgeons to control the endoscope without the assistants' intervention. In this paper, a new method is proposed for the automatic 3D-tracking of laparoscopic instruments in real-time to provide more convenient interactions between surgeons and the robotized e...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:10.3233/BME-141083
更新日期:2014-01-01 00:00:00
abstract::Food systems are complex and inhomogeneous in nature. Ultrasonic propagation velocity in the food systems, in this case processed milk cream and vegetable oils, is studied. Ultrasonic properties of the food systems are similar to those of complex biological tissues. The presence of vegetable oil as an adulterant in th...
journal_title:Bio-medical materials and engineering
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00