Abstract:
:The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somatic mutation. Environmental forces in the form of self and exogenous Ags also shape the repertoire by positively or negatively selecting B cells according to the specificity of their Ig receptors. These are dynamic processes beginning with the earliest expression of immunoglobulins in fetal life and continuing throughout life. In this review we discuss the genetic and selective mechanisms responsible for differences in the early immune system compared to that of the adult.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Kearney JF,Won WJ,Benedict C,Moratz C,Zimmer P,Oliver A,Martin F,Shu Fdoi
10.3109/08830189709068177subject
Has Abstractpub_date
1997-01-01 00:00:00pages
207-41issue
3-4eissn
0883-0185issn
1563-5244journal_volume
15pub_type
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