Abstract:
:Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where endothelial cells are patterned to display a restricted set of adhesion molecules and other regulatory compounds necessary for extravasation. Recent advances in high throughput analyses of highly purified endothelial subsets in various lymphoid tissues as well as the expansion of various transgenic animal models have shed new light on the transcriptional complexities of lymphoid tissue vascular endothelium. This review is aimed at providing a comprehensive analysis linking the functional competence of spleen and intestinal lymphoid tissues with the developmental programming and functional divergence of their vascular specification, with particular emphasis on the transcriptional control of endothelial cells exerted by Nkx2.3 homeodomain transcription factor.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Kellermayer Z,Hayasaka H,Kajtár B,Simon D,Robles EF,Martinez-Climent JA,Balogh Pdoi
10.3109/08830185.2015.1059427subject
Has Abstractpub_date
2016-11-01 00:00:00pages
489-502issue
6eissn
0883-0185issn
1563-5244journal_volume
35pub_type
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