DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection.

abstract：:The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of ...

journal_title：International reviews of immunology

authors： Samy E,Wax S,Huard B,Hess H,Schneider P

更新日期：2017-01-02 00:00:00

abstract：:Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...

journal_title：International reviews of immunology

authors： Karlen S,De Boer ML,Lipscombe RJ,Lutz W,Mordvinov VA,Sanderson CJ

更新日期：1998-01-01 00:00:00

abstract：:Immune privilege was first explored in the late 1800s by van Dooremaal, and was then extended by Medawar in the mid 1900s to fit in with emerging concepts of transplantation immunology. Modern concepts and understanding of immune privilege come from subsequent studies produced by Medawar, Billingham, and Streilein. Th...

journal_title：International reviews of immunology

authors： Stein-Streilein J,Streilein JW

更新日期：2002-03-01 00:00:00

abstract：:In these studies we have emphasized the apparent developmental hierarchy of B cell development and assigned a role for the multispecific self idiotype reactive B cells which develop first, in promoting the development of later appearing clones of B cells. These early sets of interconnecting clones of B cells bridge be...

journal_title：International reviews of immunology

authors： Vakil M,Kearney JF

更新日期：1988-03-01 00:00:00

abstract：:Although the B cell antigen receptor (BCR) transmits survival and activation signals, BCR ligation can induce apoptosis in both immature and mature B cells. BCR-mediated apoptosis is suggested to play a role in self-tolerance by deleting self-reactive B cells. Generation of an apoptotic signal through BCR appears to d...

journal_title：International reviews of immunology

authors： Tsubata T

更新日期：2001-01-01 00:00:00

abstract：:The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...

journal_title：International reviews of immunology

authors： Sulica A,Morel P,Metes D,Herberman RB

更新日期：2001-06-01 00:00:00

abstract：:The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensi...

journal_title：International reviews of immunology

authors： Chicaybam L,Sodré AL,Bonamino M

更新日期：2011-10-01 00:00:00

abstract：:Heat shock proteins (HSPs) are immunogenic, with the specificity of the immune response provided by the peptides that they chaperone. Binding of cell surface receptors by HSPs is central to the elicitation of the innate and adaptive immune responses obtained after vaccination and also plays a physiologic role in cross...

journal_title：International reviews of immunology

authors： Binder RJ

更新日期：2006-09-01 00:00:00

abstract：:Autoimmune disorders afflicting the liver comprise the bona fide autoimmune diseases, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis as well as drug-induced autoimmune-like diseases, such as halothane hepatitis. Whereas drug-induced forms of acute or chronic hepatitis often have a ...

journal_title：International reviews of immunology

authors： Christen U,Hintermann E

更新日期：2014-07-01 00:00:00

abstract：:The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, ut...

journal_title：International reviews of immunology

authors： Langdon K,Haleagrahara N

更新日期：2018-01-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including...

journal_title：International reviews of immunology

authors： Johnson PR,Hirsch VM

更新日期：1992-01-01 00:00:00

abstract：:Dendritic cells (DCs) and macrophages (Mϕs) are professional antigen-presenting cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). It is quite interesting to mention here that DCs and Mϕs use distinct strategies to combat and eliminate Mtb. Simil...

journal_title：International reviews of immunology

authors： Khan N,Vidyarthi A,Pahari S,Agrewala JN

更新日期：2016-09-02 00:00:00

abstract：:IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpected...

journal_title：International reviews of immunology

authors： Davidson NJ,Fort MM,Müller W,Leach MW,Rennick DM

更新日期：2000-01-01 00:00:00

abstract：:Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...

journal_title：International reviews of immunology

authors： Daniel V,Opelz G

更新日期：2009-01-01 00:00:00

abstract：:Multiple cytokines and growth factors are critical for the prognosis of cancer which has been regarded as a worldwide health problem. Recently, neuropeptides, soluble factors regulating a series of functions in the central nervous system, have also been demonstrated to stimulate the proliferation and migration of tumo...

journal_title：International reviews of immunology

authors： Ye Y,Liu P,Wang Y,Li H,Wei F,Cheng Y,Han L,Yu J

更新日期：2016-07-03 00:00:00

abstract：:ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive p...

journal_title：International reviews of immunology

authors： Dahlgren US,Bennet W

更新日期：2019-01-01 00:00:00

abstract：:Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pa...

journal_title：International reviews of immunology

authors： Martorelli D,Muraro E,Merlo A,Turrini R,Rosato A,Dolcetti R

更新日期：2010-08-01 00:00:00

abstract：:The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...

journal_title：International reviews of immunology

authors： Walton SF,Weir C

更新日期：2012-06-01 00:00:00

abstract：:Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in...

journal_title：International reviews of immunology

authors： Nawab A,An L,Wu J,Li G,Liu W,Zhao Y,Wu Q,Xiao M

更新日期：2019-01-01 00:00:00

abstract：:Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I coll...

journal_title：International reviews of immunology

authors： Karsenty G,Park RW

更新日期：1995-01-01 00:00:00

abstract：:The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...

journal_title：International reviews of immunology

authors： Oggioni MR,Beninati C,Boccanera M,Medaglini D,Spinosa MR,Maggi T,Conti S,Magliani W,De Bernardis F,Teti G,Cassone A,Pozzi G,Polonelli L

更新日期：2001-01-01 00:00:00

abstract：:Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lym...

journal_title：International reviews of immunology

authors： Zhang Y,Tang J,Tian Z,van Velkinburgh JC,Song J,Wu Y,Ni B

更新日期：2016-09-02 00:00:00

abstract：:Over the past few decades, advancements in molecular and cell biology have allowed scientists to identify a large number of new antigens from a variety of viral and bacterial pathogens. However, successful development of these antigens into effective vaccines strongly relies on delivery systems able to avoid the rapid...

journal_title：International reviews of immunology

authors： Cutting SM,Hong HA,Baccigalupi L,Ricca E

更新日期：2009-01-01 00:00:00

abstract：:Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where ...

journal_title：International reviews of immunology

authors： Kellermayer Z,Hayasaka H,Kajtár B,Simon D,Robles EF,Martinez-Climent JA,Balogh P

更新日期：2016-11-01 00:00:00

abstract：:The B cell repertoire consists of three tiers of clonotype diversity. One tier, which is the product of H chain V region rearrangements in the absence of N additions, is of limited diversity (less than 10(8) clonotypes) so that clonotypes of this tier would be expected to recur within and among B cells of individuals ...

journal_title：International reviews of immunology

authors： Decker DJ,Klinman NR

更新日期：1992-01-01 00:00:00

abstract：:Noncoding RNA comprises of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) that are abundantly present in mammalian transcriptome. These noncoding RNAs have been implicated in multiple biological processes through the regulation of gene expression. Each of these noncoding RNAs were found to have multiple genes ta...

journal_title：International reviews of immunology

authors： Roy S,Awasthi A

更新日期：2019-01-01 00:00:00

abstract：:Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to gen...

journal_title：International reviews of immunology

authors： George AJ,Stevenson FK

更新日期：1989-01-01 00:00:00

abstract：:The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somat...

journal_title：International reviews of immunology

authors： Kearney JF,Won WJ,Benedict C,Moratz C,Zimmer P,Oliver A,Martin F,Shu F

更新日期：1997-01-01 00:00:00

abstract：:Neonates often respond poorly to conventional vaccines or microbial infections. Immaturity of the immune system has been considered to play a role in this regard. However, accumulating evidence shows that in certain conditions, neonatal inoculation of antigens leads to protective immunity. In the particular case of DN...

journal_title：International reviews of immunology

authors： Bot A

更新日期：2000-01-01 00:00:00

abstract：:Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...

journal_title：International reviews of immunology

authors： Chiriva-Internati M

更新日期：2011-04-01 00:00:00