Abstract:
:Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to generate autologous anti-idiotypic responses which suppress individual tumors. Studies of the components of these responses are providing insight into host effector mechanisms which can be activated against tumors, and also into the many strategies adopted by the target cells in order to avoid such attack. Promising results in various animal models where tumor bearers can be treated by idiotypic immunization have led to the point where application of this approach to the treatment of certain categories of human B cell lymphoma can be considered.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
George AJ,Stevenson FKdoi
10.3109/08830188909044783subject
Has Abstractpub_date
1989-01-01 00:00:00pages
271-310issue
4eissn
0883-0185issn
1563-5244journal_volume
4pub_type
杂志文章,评审abstract::Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the ...
journal_title:International reviews of immunology
pub_type: 社论
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更新日期:2012-04-01 00:00:00
abstract::Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...
journal_title:International reviews of immunology
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abstract::Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different To...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...
journal_title:International reviews of immunology
pub_type: 杂志文章
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更新日期:2021-01-11 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1659258
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journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.3109/08830185.2012.748053
更新日期:2013-06-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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abstract::Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...
journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209055571
更新日期:1992-01-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2001-06-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:International reviews of immunology
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更新日期:2006-05-01 00:00:00