Molecular mechanisms for apoptosis induced by signaling through the B cell antigen receptor.

abstract：:Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...

journal_title：International reviews of immunology

authors： Chiriva-Internati M

更新日期：2011-04-01 00:00:00

abstract：:Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where ...

journal_title：International reviews of immunology

authors： Kellermayer Z,Hayasaka H,Kajtár B,Simon D,Robles EF,Martinez-Climent JA,Balogh P

更新日期：2016-11-01 00:00:00

abstract：:Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...

journal_title：International reviews of immunology

authors： Karlen S,De Boer ML,Lipscombe RJ,Lutz W,Mordvinov VA,Sanderson CJ

更新日期：1998-01-01 00:00:00

abstract：:Most contemporary models of hematopoiesis assume lineage fidelity of early progenitor cells. Along with this concept normal hematopoietic cells and the majority of leukemias express exclusively myeloid or lymphoid specific antigens. On the other hand, growing evidence exists challenging the lineage fidelity model. Chr...

journal_title：International reviews of immunology

authors： Schmidt CA,Przybylski GK

更新日期：2001-02-01 00:00:00

abstract：:Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the ...

journal_title：International reviews of immunology

authors： Faris M,Bot A

更新日期：2012-04-01 00:00:00

abstract：:Dendritic cells (DC) from human peripheral blood are susceptible to productive and probably to latent infection with HIV-I. Infection of DC also occurs in vivo since in HIV-seropositive individuals Langerhans' cells of the skin and DC from peripheral blood, (in preparation) are infected. In peripheral blood 3-25% of D...

journal_title：International reviews of immunology

authors： Knight SC,Macatonia SE,Patterson S

更新日期：1990-01-01 00:00:00

abstract：:Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubte...

journal_title：International reviews of immunology

authors： Shirai T,Hirose S

更新日期：2000-01-01 00:00:00

abstract：:Dendritic cells (DC) are the most potent and versatile antigen-presenting cells (APC) in the immune system. DC have an exceptional ability to comprehend the immune context of a captured antigen based on molecular signals identified from its vicinity. The analyzed information is then conveyed to other immune effector c...

journal_title：International reviews of immunology

authors： Volovitz I,Melzer S,Amar S,Bocsi J,Bloch M,Efroni S,Ram Z,Tárnok A

更新日期：2016-01-01 00:00:00

abstract：:Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they m...

journal_title：International reviews of immunology

authors： Chen H,Yang T,Zhu L,Zhao Y

更新日期：2015-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and enviro...

journal_title：International reviews of immunology

authors： Seitz HM,Matsushima GK

更新日期：2010-04-01 00:00:00

abstract：:Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...

journal_title：International reviews of immunology

authors： Cobos C,Figueroa JA,Mirandola L,Colombo M,Summers G,Figueroa A,Aulakh A,Konala V,Verma R,Riaz J,Wade R,Saadeh C,Rahman RL,Pandey A,Radhi S,Nguyen DD,Jenkins M,Chiriva-Internati M,Cobos E

更新日期：2014-10-01 00:00:00

abstract：:Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I coll...

journal_title：International reviews of immunology

authors： Karsenty G,Park RW

更新日期：1995-01-01 00:00:00

abstract：:Recurrent vulvovaginal candidiasis (RVVC) is a significant problem in women of childbearing ages and is caused by Candida albicans, a commensal organism of the intestinal and reproductive tracts. As a result of this commensalism, most healthy individuals have demonstrable Candida-specific adaptive immunity that is con...

journal_title：International reviews of immunology

authors： Fidel PL Jr

更新日期：2002-11-01 00:00:00

abstract：:The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...

journal_title：International reviews of immunology

authors： Oggioni MR,Beninati C,Boccanera M,Medaglini D,Spinosa MR,Maggi T,Conti S,Magliani W,De Bernardis F,Teti G,Cassone A,Pozzi G,Polonelli L

更新日期：2001-01-01 00:00:00

abstract：:In these studies we have emphasized the apparent developmental hierarchy of B cell development and assigned a role for the multispecific self idiotype reactive B cells which develop first, in promoting the development of later appearing clones of B cells. These early sets of interconnecting clones of B cells bridge be...

journal_title：International reviews of immunology

authors： Vakil M,Kearney JF

更新日期：1988-03-01 00:00:00

abstract：:While simultaneously maintaining homeostasis and reducing further harm to the host, the immune system is equipped to eliminate both tumors and pathogenic microorganisms. Bifurcated into cell-mediated and humoral immunity, the adaptive immune system requires a series of complex and coordinated signals to drive the prol...

journal_title：International reviews of immunology

authors： Fracchia KM,Walsh CM

更新日期：2015-01-01 00:00:00

abstract：:Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...

journal_title：International reviews of immunology

authors： Meier D,Rumbo M,Gondolesi GE

更新日期：2014-05-01 00:00:00

abstract：:ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive p...

journal_title：International reviews of immunology

authors： Dahlgren US,Bennet W

更新日期：2019-01-01 00:00:00

abstract：:The present article summarizes a series of experiments which have been performed to describe an antigen-specific suppressor cell pathway for the suppression of the erythema and edema associated with an animal model of rheumatoid arthritis, collagen induced arthritis (CIA). Initial studies utilized the adoptive transfe...

journal_title：International reviews of immunology

authors： Kresina TF

更新日期：1988-09-01 00:00:00

abstract：:Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to gen...

journal_title：International reviews of immunology

authors： George AJ,Stevenson FK

更新日期：1989-01-01 00:00:00

abstract：:The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that ...

journal_title：International reviews of immunology

authors： Martinez OM,Krams SM

更新日期：1999-01-01 00:00:00

abstract：:Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...

journal_title：International reviews of immunology

authors： Pradhan G,Raj Abraham P,Shrivastava R,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...

journal_title：International reviews of immunology

authors： Marletta S,Girolami I,Munari E,Pantanowitz L,Bernasconi R,Torresani E,Brunelli M,Eccher A

更新日期：2021-01-11 00:00:00

abstract：:Over the past few decades, advancements in molecular and cell biology have allowed scientists to identify a large number of new antigens from a variety of viral and bacterial pathogens. However, successful development of these antigens into effective vaccines strongly relies on delivery systems able to avoid the rapid...

journal_title：International reviews of immunology

authors： Cutting SM,Hong HA,Baccigalupi L,Ricca E

更新日期：2009-01-01 00:00:00

abstract：:A unifying theory of B cell development and lineage commitment is presented. There are two firmly established B lineages: cells which normally arise only from fetal sources and lack N insertions in their rearranged heavy chains; and N-containing cells which arise from adult bone marrow precursors (and perhaps from lat...

journal_title：International reviews of immunology

authors： Wortis HH

更新日期：1992-01-01 00:00:00

abstract：:Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spr...

journal_title：International reviews of immunology

authors： Bloom DC

更新日期：2004-01-01 00:00:00

abstract：:Current advances in understanding of the pathogenesis of inflammatory bowel disease have encouraged the development of many new therapies targeted at specific and non-specific mediators of the inflammatory bowel disease inflammatory pathway. Crohn's disease and ulcerative colitis, two common inflammatory bowel disease...

journal_title：International reviews of immunology

authors： Ghosh N,Chaki R,Mandal V,Lin GD,Mandal SC

更新日期：2010-01-01 00:00:00

abstract：:Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in...

journal_title：International reviews of immunology

authors： Nawab A,An L,Wu J,Li G,Liu W,Zhao Y,Wu Q,Xiao M

更新日期：2019-01-01 00:00:00

abstract：:Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modifie...

journal_title：International reviews of immunology

authors： Hilkens CM,Isaacs JD,Thomson AW

更新日期：2010-04-01 00:00:00

abstract：:IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpected...

journal_title：International reviews of immunology

authors： Davidson NJ,Fort MM,Müller W,Leach MW,Rennick DM

更新日期：2000-01-01 00:00:00