Dendritic cells in systemic lupus erythematosus.

Abstract:

:Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and environmental factors. There have been several immune mediators linked to SLE including cytokines and chemokines that have been reviewed elsewhere [ 1-3 ]. A number of articles have reviewed the role of B cells and T cells in SLE [ 4-10 ]. Here, we focus on the role of dendritic cells (DC) and innate immune factors that may regulate autoreactive B cells.

journal_name

Int Rev Immunol

authors

Seitz HM,Matsushima GK

doi

10.3109/08830181003602507

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

184-209

issue

2

eissn

0883-0185

issn

1563-5244

journal_volume

29

pub_type

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