Abstract:
:T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induction and functional heterogeneity of Th17 responses, the underlying molecular effects of Th17 response including the most relevant different cell targets of Th17 cytokines remain poorly understood. Cytokines produced by Th17 cells have broad effects on both hematopoietic and nonhematopoietic cells and can act in synergy with various inflammatory factors. In this review, we will focus on the effects of Th17-derived cytokines in the gastrointestinal tract and discuss how Th17 responses can affect both innate and adaptive immunity and may contribute to the pathogenesis of inflammatory GI processes.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Verdier J,Ruemmele FMdoi
10.3109/08830185.2013.829471subject
Has Abstractpub_date
2013-10-01 00:00:00pages
475-92issue
5-6eissn
0883-0185issn
1563-5244journal_volume
32pub_type
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