Cellular metabolism on T-cell development and function.

abstract：:The nuclear factor (NF)-kappa B family of proteins is a key regulator of inflammation, innate immunity, and cell survival and differentiation. Components of these pathways are potential targets of intervention for inflammation, infectious diseases, and cancer. However, therapeutic interventions that dampen the host re...

journal_title：International reviews of immunology

authors： Krakauer T

更新日期：2008-01-01 00:00:00

abstract：:Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to gen...

journal_title：International reviews of immunology

authors： George AJ,Stevenson FK

更新日期：1989-01-01 00:00:00

abstract：:Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubte...

journal_title：International reviews of immunology

authors： Shirai T,Hirose S

更新日期：2000-01-01 00:00:00

abstract：:Myasthenia gravis (MG) is a prototypic antibody-mediated autoimmune disease. Since the primary target antigen of the autoimmune response is known and a well-characterized animal model is available, MG is often considered an excellent situation for the application of novel specific immunotherapies, many of which are di...

journal_title：International reviews of immunology

authors： Infante AJ,Kraig E

更新日期：1999-01-01 00:00:00

abstract：:The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensi...

journal_title：International reviews of immunology

authors： Chicaybam L,Sodré AL,Bonamino M

更新日期：2011-10-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA. Regulatory mechanisms of the innate...

journal_title：International reviews of immunology

authors： Vollmer J

更新日期：2006-05-01 00:00:00

abstract：:Most contemporary models of hematopoiesis assume lineage fidelity of early progenitor cells. Along with this concept normal hematopoietic cells and the majority of leukemias express exclusively myeloid or lymphoid specific antigens. On the other hand, growing evidence exists challenging the lineage fidelity model. Chr...

journal_title：International reviews of immunology

authors： Schmidt CA,Przybylski GK

更新日期：2001-02-01 00:00:00

abstract：:The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somat...

journal_title：International reviews of immunology

authors： Kearney JF,Won WJ,Benedict C,Moratz C,Zimmer P,Oliver A,Martin F,Shu F

更新日期：1997-01-01 00:00:00

abstract：:Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...

journal_title：International reviews of immunology

authors： Perl A,Gergely P Jr,Banki K

更新日期：2004-05-01 00:00:00

abstract：:Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modifie...

journal_title：International reviews of immunology

authors： Hilkens CM,Isaacs JD,Thomson AW

更新日期：2010-04-01 00:00:00

abstract：:The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...

journal_title：International reviews of immunology

authors： Sulica A,Morel P,Metes D,Herberman RB

更新日期：2001-06-01 00:00:00

abstract：:The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, ut...

journal_title：International reviews of immunology

authors： Langdon K,Haleagrahara N

更新日期：2018-01-01 00:00:00

abstract：:The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of ...

journal_title：International reviews of immunology

authors： Samy E,Wax S,Huard B,Hess H,Schneider P

更新日期：2017-01-02 00:00:00

abstract：:Genetic alterations of the BCL-6 gene in mice and man have established BCL-6 as a pivotal regulator of normal differentiation of B and T lymphocytes as well as one of the most frequently translocated oncogenes in human B cell lymphomas. As an oncogene, BCL-6 has not been easy to place into existing paradigms of cellul...

journal_title：International reviews of immunology

authors： Staudt LM,Dent AL,Shaffer AL,Yu X

更新日期：1999-01-01 00:00:00

abstract：:The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...

journal_title：International reviews of immunology

authors： Oggioni MR,Beninati C,Boccanera M,Medaglini D,Spinosa MR,Maggi T,Conti S,Magliani W,De Bernardis F,Teti G,Cassone A,Pozzi G,Polonelli L

更新日期：2001-01-01 00:00:00

abstract：:CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man, which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells. CD40/CD40L interactions are now known to be essential for the initiation of antibody responses to T-dependent antigens. In this review we discuss th...

journal_title：International reviews of immunology

authors： Klaus GG,Choi MS,Lam EW,Johnson-Léger C,Cliff J

更新日期：1997-01-01 00:00:00

abstract：:Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...

journal_title：International reviews of immunology

authors： Cobos C,Figueroa JA,Mirandola L,Colombo M,Summers G,Figueroa A,Aulakh A,Konala V,Verma R,Riaz J,Wade R,Saadeh C,Rahman RL,Pandey A,Radhi S,Nguyen DD,Jenkins M,Chiriva-Internati M,Cobos E

更新日期：2014-10-01 00:00:00

abstract：:Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to its action on both immune and tumor cells. It has the ability to "precondition" dendritic cells, allowing them to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an ideal therapy for combination with...

journal_title：International reviews of immunology

authors： Khong A,Nelson DJ,Nowak AK,Lake RA,Robinson BW

更新日期：2012-08-01 00:00:00

abstract：:The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...

journal_title：International reviews of immunology

authors： Blaser K,Heusser CH

更新日期：1987-01-01 00:00:00

abstract：:Current advances in understanding of the pathogenesis of inflammatory bowel disease have encouraged the development of many new therapies targeted at specific and non-specific mediators of the inflammatory bowel disease inflammatory pathway. Crohn's disease and ulcerative colitis, two common inflammatory bowel disease...

journal_title：International reviews of immunology

authors： Ghosh N,Chaki R,Mandal V,Lin GD,Mandal SC

更新日期：2010-01-01 00:00:00

abstract：:Although the B cell antigen receptor (BCR) transmits survival and activation signals, BCR ligation can induce apoptosis in both immature and mature B cells. BCR-mediated apoptosis is suggested to play a role in self-tolerance by deleting self-reactive B cells. Generation of an apoptotic signal through BCR appears to d...

journal_title：International reviews of immunology

authors： Tsubata T

更新日期：2001-01-01 00:00:00

abstract：:The present article summarizes a series of experiments which have been performed to describe an antigen-specific suppressor cell pathway for the suppression of the erythema and edema associated with an animal model of rheumatoid arthritis, collagen induced arthritis (CIA). Initial studies utilized the adoptive transfe...

journal_title：International reviews of immunology

authors： Kresina TF

更新日期：1988-09-01 00:00:00

abstract：:The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that ...

journal_title：International reviews of immunology

authors： Martinez OM,Krams SM

更新日期：1999-01-01 00:00:00

abstract：:Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokine...

journal_title：International reviews of immunology

authors： Brault MS,Kurt RA

更新日期：2003-05-01 00:00:00

abstract：:T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induc...

journal_title：International reviews of immunology

authors： Verdier J,Ruemmele FM

更新日期：2013-10-01 00:00:00

abstract：:The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...

journal_title：International reviews of immunology

authors： Lewis DE,Giorgi JV

更新日期：1990-01-01 00:00:00

abstract：:Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...

journal_title：International reviews of immunology

authors： Offner H,Vandenbark AA

更新日期：2005-09-01 00:00:00

abstract：:Noncoding RNA comprises of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) that are abundantly present in mammalian transcriptome. These noncoding RNAs have been implicated in multiple biological processes through the regulation of gene expression. Each of these noncoding RNAs were found to have multiple genes ta...

journal_title：International reviews of immunology

authors： Roy S,Awasthi A

更新日期：2019-01-01 00:00:00

abstract：:Recurrent vulvovaginal candidiasis (RVVC) is a significant problem in women of childbearing ages and is caused by Candida albicans, a commensal organism of the intestinal and reproductive tracts. As a result of this commensalism, most healthy individuals have demonstrable Candida-specific adaptive immunity that is con...

journal_title：International reviews of immunology

authors： Fidel PL Jr

更新日期：2002-11-01 00:00:00

abstract：:Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...

journal_title：International reviews of immunology

authors： Chiriva-Internati M

更新日期：2011-04-01 00:00:00