CD40: a pivotal receptor in the determination of life/death decisions in B lymphocytes.

Abstract:

:CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man, which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells. CD40/CD40L interactions are now known to be essential for the initiation of antibody responses to T-dependent antigens. In this review we discuss the immunobiology of CD40, with a special emphasis on our own studies in the mouse. These have focused on signal transduction via CD40, the role of cytokines (both T cell-derived and B cell-derived) in CD40-mediated B cell activation, and the role of CD40 in protecting B cells from apoptotic cell death. The available data indicate clearly that this protein is a pivotal receptor on B cells, both for the delivery of activating signals and for promoting B cell survival.

journal_name

Int Rev Immunol

authors

Klaus GG,Choi MS,Lam EW,Johnson-Léger C,Cliff J

doi

10.3109/08830189709068169

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

5-31

issue

1-2

eissn

0883-0185

issn

1563-5244

journal_volume

15

pub_type

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