Development of dendritic cell-based immunotherapy for autoimmunity.

abstract：:Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded b...

journal_title：International reviews of immunology

authors： Zhou XJ,Cheng FJ,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is considered a prototypical autoimmune disorder based mainly on data from experimental models in the mouse. Several different experimental mode...

journal_title：International reviews of immunology

authors： Forrester JV,Klaska IP,Yu T,Kuffova L

更新日期：2013-02-01 00:00:00

abstract：:The nuclear factor (NF)-kappa B family of proteins is a key regulator of inflammation, innate immunity, and cell survival and differentiation. Components of these pathways are potential targets of intervention for inflammation, infectious diseases, and cancer. However, therapeutic interventions that dampen the host re...

journal_title：International reviews of immunology

authors： Krakauer T

更新日期：2008-01-01 00:00:00

abstract：:The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...

journal_title：International reviews of immunology

authors： Lewis DE,Giorgi JV

更新日期：1990-01-01 00:00:00

abstract：:In this issue, we are hosting several reviews on topics of broad interests, such as therapeutic or prophylactic antibodies, and the role of autophagy in autoimmunity. ...

journal_title：International reviews of immunology

authors： Bot A

更新日期：2015-05-01 00:00:00

abstract：:Noncoding RNA comprises of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) that are abundantly present in mammalian transcriptome. These noncoding RNAs have been implicated in multiple biological processes through the regulation of gene expression. Each of these noncoding RNAs were found to have multiple genes ta...

journal_title：International reviews of immunology

authors： Roy S,Awasthi A

更新日期：2019-01-01 00:00:00

abstract：:Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokine...

journal_title：International reviews of immunology

authors： Brault MS,Kurt RA

更新日期：2003-05-01 00:00:00

abstract：:When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved ...

journal_title：International reviews of immunology

authors： Aubert M,Jerome KR

更新日期：2003-09-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including...

journal_title：International reviews of immunology

authors： Johnson PR,Hirsch VM

更新日期：1992-01-01 00:00:00

abstract：:Recurrent vulvovaginal candidiasis (RVVC) is a significant problem in women of childbearing ages and is caused by Candida albicans, a commensal organism of the intestinal and reproductive tracts. As a result of this commensalism, most healthy individuals have demonstrable Candida-specific adaptive immunity that is con...

journal_title：International reviews of immunology

authors： Fidel PL Jr

更新日期：2002-11-01 00:00:00

abstract：:Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they m...

journal_title：International reviews of immunology

authors： Chen H,Yang T,Zhu L,Zhao Y

更新日期：2015-01-01 00:00:00

abstract：:Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...

journal_title：International reviews of immunology

authors： Meier D,Rumbo M,Gondolesi GE

更新日期：2014-05-01 00:00:00

abstract：:Dendritic cells (DC) from human peripheral blood are susceptible to productive and probably to latent infection with HIV-I. Infection of DC also occurs in vivo since in HIV-seropositive individuals Langerhans' cells of the skin and DC from peripheral blood, (in preparation) are infected. In peripheral blood 3-25% of D...

journal_title：International reviews of immunology

authors： Knight SC,Macatonia SE,Patterson S

更新日期：1990-01-01 00:00:00

abstract：:Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in...

journal_title：International reviews of immunology

authors： Nawab A,An L,Wu J,Li G,Liu W,Zhao Y,Wu Q,Xiao M

更新日期：2019-01-01 00:00:00

abstract：:Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to gen...

journal_title：International reviews of immunology

authors： George AJ,Stevenson FK

更新日期：1989-01-01 00:00:00

abstract：:Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these m...

journal_title：International reviews of immunology

authors： Krensky AM,Clayberger C

更新日期：1996-01-01 00:00:00

abstract：:Autoimmune disorders afflicting the liver comprise the bona fide autoimmune diseases, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis as well as drug-induced autoimmune-like diseases, such as halothane hepatitis. Whereas drug-induced forms of acute or chronic hepatitis often have a ...

journal_title：International reviews of immunology

authors： Christen U,Hintermann E

更新日期：2014-07-01 00:00:00

abstract：:The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...

journal_title：International reviews of immunology

authors： Oggioni MR,Beninati C,Boccanera M,Medaglini D,Spinosa MR,Maggi T,Conti S,Magliani W,De Bernardis F,Teti G,Cassone A,Pozzi G,Polonelli L

更新日期：2001-01-01 00:00:00

abstract：:Almost 30 years have passed since adult T-cell leukemia (ATL) was identified as a new disease entity in Japan. During this period, its causative agent, human T-cell leukemia virus (HTLV-1), was discovered, and a crucial role of the viral product Tax in ATL leukemogenesis was demonstrated. Recently, another HTLV-1 prod...

journal_title：International reviews of immunology

authors： Murata K,Yamada Y

更新日期：2007-09-01 00:00:00

abstract：:Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines,...

journal_title：International reviews of immunology

authors： Figueroa JA,Reidy A,Mirandola L,Trotter K,Suvorava N,Figueroa A,Konala V,Aulakh A,Littlefield L,Grizzi F,Rahman RL,Jenkins MR,Musgrove B,Radhi S,D'Cunha N,D'Cunha LN,Hermonat PL,Cobos E,Chiriva-Internati M

更新日期：2015-03-01 00:00:00

abstract：:The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...

journal_title：International reviews of immunology

authors： Lopes LF,Ruiz Miyazawa KW,de Almeida ER,Serafim KG,de Almeida Gualtieri K,Costa IC,Felipe I,Pavanelli WR,Watanabe MA

更新日期：2013-06-01 00:00:00

abstract：:Although the B cell antigen receptor (BCR) transmits survival and activation signals, BCR ligation can induce apoptosis in both immature and mature B cells. BCR-mediated apoptosis is suggested to play a role in self-tolerance by deleting self-reactive B cells. Generation of an apoptotic signal through BCR appears to d...

journal_title：International reviews of immunology

authors： Tsubata T

更新日期：2001-01-01 00:00:00

abstract：:The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...

journal_title：International reviews of immunology

authors： Sulica A,Morel P,Metes D,Herberman RB

更新日期：2001-06-01 00:00:00

abstract：:The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...

journal_title：International reviews of immunology

authors： Walton SF,Weir C

更新日期：2012-06-01 00:00:00

abstract：:Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1 and IL-12 occurs during the night and early morning at a time when plasma cortisol is lowest. The existence of a causal relationship between plasma cortisol and production...

journal_title：International reviews of immunology

authors： Petrovsky N,Harrison LC

更新日期：1998-01-01 00:00:00

abstract：:Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...

journal_title：International reviews of immunology

authors： Chiriva-Internati M

更新日期：2011-04-01 00:00:00

abstract：:Classical and non-classical monocytes are two well-defined subsets of monocytes displaying distinct roles. They differentially express numerous genes relevant to their primary role. Using five independent transcriptomic microarray datasets, we ruled out several inconsistent genes and identified common genes consistent...

journal_title：International reviews of immunology

authors： Anbazhagan K,Duroux-Richard I,Jorgensen C,Apparailly F

更新日期：2014-11-01 00:00:00

abstract：:The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated ...

journal_title：International reviews of immunology

authors： Tsai HT,Tsai TH,Lu TM,Yang CC

更新日期：2008-01-01 00:00:00

abstract：:Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...

journal_title：International reviews of immunology

authors： Karlen S,De Boer ML,Lipscombe RJ,Lutz W,Mordvinov VA,Sanderson CJ

更新日期：1998-01-01 00:00:00

abstract：:CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man, which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells. CD40/CD40L interactions are now known to be essential for the initiation of antibody responses to T-dependent antigens. In this review we discuss th...

journal_title：International reviews of immunology

authors： Klaus GG,Choi MS,Lam EW,Johnson-Léger C,Cliff J

更新日期：1997-01-01 00:00:00