Abstract:
:Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or absent in normal tissues, other than the testis. Sperm protein 17 is expressed by tumors, including ovarian cancer, indicating that it is an ideal target for cancer immunotherapy, and plays a role in tumorigenesis and drug resistance. This review recapitulates the milestones of sperm protein 17 research and highlights its potential use in translational medicine.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Chiriva-Internati Mdoi
10.3109/08830185.2011.569903subject
Has Abstractpub_date
2011-04-01 00:00:00pages
138-49issue
2-3eissn
0883-0185issn
1563-5244journal_volume
30pub_type
杂志文章,评审abstract::IVIgG preparations are now widely applied for immune modulatory treatment in various forms of autoimmune and immune complex diseases. Several controlled studies clearly demonstrated the clinical efficacy of this type of treatment; the underlying pathophysiological mechanisms, however, have yet to be elucidated. Among ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188909061984
更新日期:1989-01-01 00:00:00
abstract::Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1059427
更新日期:2016-11-01 00:00:00
abstract::Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1 and IL-12 occurs during the night and early morning at a time when plasma cortisol is lowest. The existence of a causal relationship between plasma cortisol and production...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809043012
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830185.2020.1869732
更新日期:2021-01-11 00:00:00
abstract::Recurrent vulvovaginal candidiasis (RVVC) is a significant problem in women of childbearing ages and is caused by Candida albicans, a commensal organism of the intestinal and reproductive tracts. As a result of this commensalism, most healthy individuals have demonstrable Candida-specific adaptive immunity that is con...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180215015
更新日期:2002-11-01 00:00:00
abstract::Immune privilege was first explored in the late 1800s by van Dooremaal, and was then extended by Medawar in the mid 1900s to fit in with emerging concepts of transplantation immunology. Modern concepts and understanding of immune privilege come from subsequent studies produced by Medawar, Billingham, and Streilein. Th...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180212066
更新日期:2002-03-01 00:00:00
abstract::Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these m...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189609061746
更新日期:1996-01-01 00:00:00
abstract::The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180802295757
更新日期:2008-01-01 00:00:00
abstract::The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109054414
更新日期:2001-06-01 00:00:00
abstract::Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spr...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180490265592
更新日期:2004-01-01 00:00:00
abstract::The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.3109/08830185.2012.748053
更新日期:2013-06-01 00:00:00
abstract::Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830180902929404
更新日期:2009-01-01 00:00:00
abstract::Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to its action on both immune and tumor cells. It has the ability to "precondition" dendritic cells, allowing them to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an ideal therapy for combination with...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.698338
更新日期:2012-08-01 00:00:00
abstract::Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180490452576
更新日期:2004-05-01 00:00:00
abstract::The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009061761
更新日期:1990-01-01 00:00:00
abstract::Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they m...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.902452
更新日期:2015-01-01 00:00:00
abstract::Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.911857
更新日期:2014-10-01 00:00:00
abstract::The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188709044749
更新日期:1987-01-01 00:00:00
abstract::Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pa...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2010.489658
更新日期:2010-08-01 00:00:00
abstract::While simultaneously maintaining homeostasis and reducing further harm to the host, the immune system is equipped to eliminate both tumors and pathogenic microorganisms. Bifurcated into cell-mediated and humoral immunity, the adaptive immune system requires a series of complex and coordinated signals to drive the prol...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.974748
更新日期:2015-01-01 00:00:00
abstract::Over the past few decades, advancements in molecular and cell biology have allowed scientists to identify a large number of new antigens from a variety of viral and bacterial pathogens. However, successful development of these antigens into effective vaccines strongly relies on delivery systems able to avoid the rapid...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903215605
更新日期:2009-01-01 00:00:00
abstract::The development of a strong cellular immune response is critical for the control of the intracellular pathogen Toxoplasma gondii. This occurs by activation of a complex, integrated immune response, which utilizes cells of the innate and adaptive immune systems. In the last two decades there have been major advances in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180213281
更新日期:2002-07-01 00:00:00
abstract::The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somat...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189709068177
更新日期:1997-01-01 00:00:00
abstract::ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive p...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1601720
更新日期:2019-01-01 00:00:00
abstract::Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modifie...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903281193
更新日期:2010-04-01 00:00:00
abstract::Neonates often respond poorly to conventional vaccines or microbial infections. Immaturity of the immune system has been considered to play a role in this regard. However, accumulating evidence shows that in certain conditions, neonatal inoculation of antigens leads to protective immunity. In the particular case of DN...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180009088506
更新日期:2000-01-01 00:00:00
abstract::T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.829471
更新日期:2013-10-01 00:00:00
abstract::The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109043039
更新日期:2001-01-01 00:00:00
abstract::The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189909088497
更新日期:1999-01-01 00:00:00
abstract::Vascular endothelial dysfunction (ED) forms the cornerstone in the development of atherosclerotic lesions that clinically manifest as ischemia, myocardial infarction, stroke or peripheral arterial disease. ED can be triggered by various risk factors including hypercholesterolemia, hypertension, hyperhomocystenemia and...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830185.2020.1866568
更新日期:2021-01-13 00:00:00