Abstract:
:Immune privilege was first explored in the late 1800s by van Dooremaal, and was then extended by Medawar in the mid 1900s to fit in with emerging concepts of transplantation immunology. Modern concepts and understanding of immune privilege come from subsequent studies produced by Medawar, Billingham, and Streilein. The exploitation of the model of anterior chamber immune deviation (ACAID) in mice has allowed us to look at both cellular and molecular mechanisms involved in the prevention of potentially damaging immune responses in such privileged sites. This review gives a historical perspective of the immune privilege research and provides up-to-date information of molecules, cells, and concepts newly recognized as contributing to tolerance induction induced in such specialized areas of the body. Evidence is given to support the idea that application of such information may lead to potential for therapeutic applications of ACAID mechanisms in prevention of progression of immune-inflammatory diseases in humans.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Stein-Streilein J,Streilein JWdoi
10.1080/08830180212066subject
Has Abstractpub_date
2002-03-01 00:00:00pages
123-52issue
2-3eissn
0883-0185issn
1563-5244journal_volume
21pub_type
杂志文章,评审abstract::Two of the key events in the pathogenesis of rheumatoid arthritis are the synovial cell proliferation and lymphocyte infiltration into the synovium. The resulting synovitis is longlasting and leads to destructive arthritis, which is a hallmark of rheumatoid arthritis. Accumulating evidence suggests that one of the key...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809054411
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journal_title:International reviews of immunology
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doi:10.3109/08830189709045707
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 社论
doi:10.3109/08830185.2012.671692
更新日期:2012-04-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109056725
更新日期:2001-02-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1648454
更新日期:2019-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180590884648
更新日期:2005-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180802295757
更新日期:2008-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180009088506
更新日期:2000-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809044773
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809051185
更新日期:1988-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and enviro...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2001-06-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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更新日期:2017-01-02 00:00:00