Abstract:
:The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these autoantibodies infected with H. pylori display histopathological and clinical features that are similar to those of autoimmune gastritis (AIG). This review will focus on the T helper cell responses, cytokines, and adhesion molecules involved in corpus mucosal atrophy in chronic H. pylori gastritis and in AIG, and the role of H. pylori in the onset of AIG.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Bergman MP,Vandenbroucke-Grauls CM,Appelmelk BJ,D'Elios MM,Amedei A,Azzurri A,Benagiano M,Del Prete Gdoi
10.1080/08830180590884648subject
Has Abstractpub_date
2005-01-01 00:00:00pages
63-91issue
1-2eissn
0883-0185issn
1563-5244pii
TNGWDJWA41G6T16Njournal_volume
24pub_type
杂志文章,评审abstract::The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2016.1276903
更新日期:2017-01-02 00:00:00
abstract::Although the B cell antigen receptor (BCR) transmits survival and activation signals, BCR ligation can induce apoptosis in both immature and mature B cells. BCR-mediated apoptosis is suggested to play a role in self-tolerance by deleting self-reactive B cells. Generation of an apoptotic signal through BCR appears to d...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109045590
更新日期:2001-01-01 00:00:00
abstract::Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209056641
更新日期:1992-01-01 00:00:00
abstract::The present article summarizes a series of experiments which have been performed to describe an antigen-specific suppressor cell pathway for the suppression of the erythema and edema associated with an animal model of rheumatoid arthritis, collagen induced arthritis (CIA). Initial studies utilized the adoptive transfe...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809044773
更新日期:1988-09-01 00:00:00
abstract::In this issue, we are hosting several reviews on topics of broad interests, such as therapeutic or prophylactic antibodies, and the role of autophagy in autoimmunity. ...
journal_title:International reviews of immunology
pub_type: 社论
doi:10.3109/08830185.2015.1041855
更新日期:2015-05-01 00:00:00
abstract::Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines,...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1018419
更新日期:2015-03-01 00:00:00
abstract::Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1059427
更新日期:2016-11-01 00:00:00
abstract::Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.911857
更新日期:2014-10-01 00:00:00
abstract::IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpected...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180009048392
更新日期:2000-01-01 00:00:00
abstract::Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lym...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1068304
更新日期:2016-09-02 00:00:00
abstract::The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188709044749
更新日期:1987-01-01 00:00:00
abstract::Hashimoto's thyroiditis (HT), an autoimmune thyroid disease (AITD), is becoming more and more prevalent in the recent years. Data on family and twin studies carry evidence for strong genetic influence on AITD susceptibility and development. The most common approaches to unravel the background of those diseases are who...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.755175
更新日期:2013-06-01 00:00:00
abstract::Dendritic cells (DCs) and macrophages (Mϕs) are professional antigen-presenting cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). It is quite interesting to mention here that DCs and Mϕs use distinct strategies to combat and eliminate Mtb. Simil...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1015718
更新日期:2016-09-02 00:00:00
abstract::The C-type lectins DC-SIGN, DC-SIGNR and LSECtin are encoded by the lectin gene cluster on chromosome 19p13.3 and perform cell-adhesion and pathogen recognition functions on dendritic cells, liver cells and lymph node sinusoidal endothelial cells. DC-SIGN and DC-SIGNR share similar overall gene and protein molecule st...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.834897
更新日期:2014-01-01 00:00:00
abstract::Genetic alterations of the BCL-6 gene in mice and man have established BCL-6 as a pivotal regulator of normal differentiation of B and T lymphocytes as well as one of the most frequently translocated oncogenes in human B cell lymphomas. As an oncogene, BCL-6 has not been easy to place into existing paradigms of cellul...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189909088490
更新日期:1999-01-01 00:00:00
abstract::The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109054414
更新日期:2001-06-01 00:00:00
abstract::Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180500371462
更新日期:2005-09-01 00:00:00
abstract::Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1 and IL-12 occurs during the night and early morning at a time when plasma cortisol is lowest. The existence of a causal relationship between plasma cortisol and production...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809043012
更新日期:1998-01-01 00:00:00
abstract::Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to its action on both immune and tumor cells. It has the ability to "precondition" dendritic cells, allowing them to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an ideal therapy for combination with...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.698338
更新日期:2012-08-01 00:00:00
abstract::CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man, which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells. CD40/CD40L interactions are now known to be essential for the initiation of antibody responses to T-dependent antigens. In this review we discuss th...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189709068169
更新日期:1997-01-01 00:00:00
abstract::Multiple cytokines and growth factors are critical for the prognosis of cancer which has been regarded as a worldwide health problem. Recently, neuropeptides, soluble factors regulating a series of functions in the central nervous system, have also been demonstrated to stimulate the proliferation and migration of tumo...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.952412
更新日期:2016-07-03 00:00:00
abstract::Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180490452576
更新日期:2004-05-01 00:00:00
abstract::Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modifie...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903281193
更新日期:2010-04-01 00:00:00
abstract::The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009061761
更新日期:1990-01-01 00:00:00
abstract::Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1592169
更新日期:2019-01-01 00:00:00
abstract::The development of a strong cellular immune response is critical for the control of the intracellular pathogen Toxoplasma gondii. This occurs by activation of a complex, integrated immune response, which utilizes cells of the innate and adaptive immune systems. In the last two decades there have been major advances in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180213281
更新日期:2002-07-01 00:00:00
abstract::A unifying theory of B cell development and lineage commitment is presented. There are two firmly established B lineages: cells which normally arise only from fetal sources and lack N insertions in their rearranged heavy chains; and N-containing cells which arise from adult bone marrow precursors (and perhaps from lat...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209055576
更新日期:1992-01-01 00:00:00
abstract::The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.667180
更新日期:2012-06-01 00:00:00
abstract::The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-kappaB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chem...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903281185
更新日期:2010-04-01 00:00:00
abstract::The B cell repertoire consists of three tiers of clonotype diversity. One tier, which is the product of H chain V region rearrangements in the absence of N additions, is of limited diversity (less than 10(8) clonotypes) so that clonotypes of this tier would be expected to recur within and among B cells of individuals ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209055571
更新日期:1992-01-01 00:00:00