Abstract:
:The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-kappaB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3(high) tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Vlad G,Chang CC,Colovai AI,Vasilescu ER,Cortesini R,Suciu-Foca Ndoi
10.3109/08830180903281185subject
Has Abstractpub_date
2010-04-01 00:00:00pages
119-32issue
2eissn
0883-0185issn
1563-5244journal_volume
29pub_type
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