Abstract:
:A unifying theory of B cell development and lineage commitment is presented. There are two firmly established B lineages: cells which normally arise only from fetal sources and lack N insertions in their rearranged heavy chains; and N-containing cells which arise from adult bone marrow precursors (and perhaps from late fetal sources). Commitment to the expression of CD5 and the capacity for long-life (or self-renewal) are induced as a consequence of sIg cross-linking, typically by a repeating epitope, thymus independent type two antigen. Alternatively, activation resulting from cognate interaction with a helper T cell does not induce CD5 but results in lower expression of J11d. In this case activation occurs in the absence of sIg cross-linking. It is further proposed that differences in the Ig repertoire make it highly likely that fetal/neonatal, but not adult derived B cells will be induced to express CD5. The model offers a plausible explanation for the correlation of CD5 expression and natural autoantibody production by neonatal B cells. Possible sources of pathogenic autoantibody are discussed in the context of this model.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Wortis HHdoi
10.3109/08830189209055576subject
Has Abstractpub_date
1992-01-01 00:00:00pages
235-46issue
2-3eissn
0883-0185issn
1563-5244journal_volume
8pub_type
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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更新日期:2015-05-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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更新日期:2013-06-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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