SIV infection of macaques as a model for AIDS pathogenesis.

abstract：:Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pa...

journal_title：International reviews of immunology

authors： Martorelli D,Muraro E,Merlo A,Turrini R,Rosato A,Dolcetti R

更新日期：2010-08-01 00:00:00

abstract：:Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lym...

journal_title：International reviews of immunology

authors： Zhang Y,Tang J,Tian Z,van Velkinburgh JC,Song J,Wu Y,Ni B

更新日期：2016-09-02 00:00:00

abstract：:Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded b...

journal_title：International reviews of immunology

authors： Zhou XJ,Cheng FJ,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...

journal_title：International reviews of immunology

authors： Pradhan G,Raj Abraham P,Shrivastava R,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...

journal_title：International reviews of immunology

authors： Daniel V,Opelz G

更新日期：2009-01-01 00:00:00

abstract：:Current advances in understanding of the pathogenesis of inflammatory bowel disease have encouraged the development of many new therapies targeted at specific and non-specific mediators of the inflammatory bowel disease inflammatory pathway. Crohn's disease and ulcerative colitis, two common inflammatory bowel disease...

journal_title：International reviews of immunology

authors： Ghosh N,Chaki R,Mandal V,Lin GD,Mandal SC

更新日期：2010-01-01 00:00:00

abstract：:The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...

journal_title：International reviews of immunology

authors： Walton SF,Weir C

更新日期：2012-06-01 00:00:00

abstract：:Noncoding RNA comprises of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) that are abundantly present in mammalian transcriptome. These noncoding RNAs have been implicated in multiple biological processes through the regulation of gene expression. Each of these noncoding RNAs were found to have multiple genes ta...

journal_title：International reviews of immunology

authors： Roy S,Awasthi A

更新日期：2019-01-01 00:00:00

abstract：:Classical and non-classical monocytes are two well-defined subsets of monocytes displaying distinct roles. They differentially express numerous genes relevant to their primary role. Using five independent transcriptomic microarray datasets, we ruled out several inconsistent genes and identified common genes consistent...

journal_title：International reviews of immunology

authors： Anbazhagan K,Duroux-Richard I,Jorgensen C,Apparailly F

更新日期：2014-11-01 00:00:00

abstract：:Human membrane and soluble Fc epsilon receptors (Fc epsilon RI, Fc epsilon RII/CD23) and Fc gamma receptors (Fc gamma RI/CD64, Fc gamma RII/CD32, Fc gamma RIII/CD16) have been implicated in a number of diseases. Their functional roles such as capture and clearance of immune complexes, antibody-dependent cell cytotoxic...

journal_title：International reviews of immunology

authors： Rouard H,Tamasdan S,Moncuit J,Moutel S,Michon J,Fridman WH,Teillaud JL

更新日期：1997-01-01 00:00:00

abstract：:Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they m...

journal_title：International reviews of immunology

authors： Chen H,Yang T,Zhu L,Zhao Y

更新日期：2015-01-01 00:00:00

abstract：:Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokine...

journal_title：International reviews of immunology

authors： Brault MS,Kurt RA

更新日期：2003-05-01 00:00:00

abstract：:In this issue, we are hosting several reviews on topics of broad interests, such as therapeutic or prophylactic antibodies, and the role of autophagy in autoimmunity. ...

journal_title：International reviews of immunology

authors： Bot A

更新日期：2015-05-01 00:00:00

abstract：:The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...

journal_title：International reviews of immunology

authors： Sulica A,Morel P,Metes D,Herberman RB

更新日期：2001-06-01 00:00:00

abstract：:The B cell repertoire consists of three tiers of clonotype diversity. One tier, which is the product of H chain V region rearrangements in the absence of N additions, is of limited diversity (less than 10(8) clonotypes) so that clonotypes of this tier would be expected to recur within and among B cells of individuals ...

journal_title：International reviews of immunology

authors： Decker DJ,Klinman NR

更新日期：1992-01-01 00:00:00

abstract：:The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...

journal_title：International reviews of immunology

authors： Lewis DE,Giorgi JV

更新日期：1990-01-01 00:00:00

abstract：:Most contemporary models of hematopoiesis assume lineage fidelity of early progenitor cells. Along with this concept normal hematopoietic cells and the majority of leukemias express exclusively myeloid or lymphoid specific antigens. On the other hand, growing evidence exists challenging the lineage fidelity model. Chr...

journal_title：International reviews of immunology

authors： Schmidt CA,Przybylski GK

更新日期：2001-02-01 00:00:00

abstract：:Almost 30 years have passed since adult T-cell leukemia (ATL) was identified as a new disease entity in Japan. During this period, its causative agent, human T-cell leukemia virus (HTLV-1), was discovered, and a crucial role of the viral product Tax in ATL leukemogenesis was demonstrated. Recently, another HTLV-1 prod...

journal_title：International reviews of immunology

authors： Murata K,Yamada Y

更新日期：2007-09-01 00:00:00

abstract：:Dendritic cells (DC) are the most potent and versatile antigen-presenting cells (APC) in the immune system. DC have an exceptional ability to comprehend the immune context of a captured antigen based on molecular signals identified from its vicinity. The analyzed information is then conveyed to other immune effector c...

journal_title：International reviews of immunology

authors： Volovitz I,Melzer S,Amar S,Bocsi J,Bloch M,Efroni S,Ram Z,Tárnok A

更新日期：2016-01-01 00:00:00

abstract：:When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved ...

journal_title：International reviews of immunology

authors： Aubert M,Jerome KR

更新日期：2003-09-01 00:00:00

abstract：:Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spr...

journal_title：International reviews of immunology

authors： Bloom DC

更新日期：2004-01-01 00:00:00

abstract：:Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the ...

journal_title：International reviews of immunology

authors： Faris M,Bot A

更新日期：2012-04-01 00:00:00

abstract：:Over the past few decades, advancements in molecular and cell biology have allowed scientists to identify a large number of new antigens from a variety of viral and bacterial pathogens. However, successful development of these antigens into effective vaccines strongly relies on delivery systems able to avoid the rapid...

journal_title：International reviews of immunology

authors： Cutting SM,Hong HA,Baccigalupi L,Ricca E

更新日期：2009-01-01 00:00:00

abstract：:In these studies we have emphasized the apparent developmental hierarchy of B cell development and assigned a role for the multispecific self idiotype reactive B cells which develop first, in promoting the development of later appearing clones of B cells. These early sets of interconnecting clones of B cells bridge be...

journal_title：International reviews of immunology

authors： Vakil M,Kearney JF

更新日期：1988-03-01 00:00:00

abstract：:The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somat...

journal_title：International reviews of immunology

authors： Kearney JF,Won WJ,Benedict C,Moratz C,Zimmer P,Oliver A,Martin F,Shu F

更新日期：1997-01-01 00:00:00

abstract：:Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is considered a prototypical autoimmune disorder based mainly on data from experimental models in the mouse. Several different experimental mode...

journal_title：International reviews of immunology

authors： Forrester JV,Klaska IP,Yu T,Kuffova L

更新日期：2013-02-01 00:00:00

abstract：:IVIgG preparations are now widely applied for immune modulatory treatment in various forms of autoimmune and immune complex diseases. Several controlled studies clearly demonstrated the clinical efficacy of this type of treatment; the underlying pathophysiological mechanisms, however, have yet to be elucidated. Among ...

journal_title：International reviews of immunology

authors： Mannhalter JW,Eibl MM

更新日期：1989-01-01 00:00:00

abstract：:A technology is described which combines the power of T lymphocytes in eliminating unwanted cells and causing beneficial inflammatory reactions with the great advantages of monoclonal antibodies. We show that heteroconjugate antibodies and hybrid antibodies, in which one of the component binding sites is anti-T-cell r...

journal_title：International reviews of immunology

authors： Staerz UD,Bevan MJ

更新日期：1989-05-01 00:00:00

abstract：:The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of ...

journal_title：International reviews of immunology

authors： Samy E,Wax S,Huard B,Hess H,Schneider P

更新日期：2017-01-02 00:00:00

abstract：:Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...

journal_title：International reviews of immunology

authors： Meier D,Rumbo M,Gondolesi GE

更新日期：2014-05-01 00:00:00