Abstract:
:Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the discovery and development of molecular targeted therapies against Tec kinases, most notably to date Btk, already showing promising clinical activity in B cell lymphoma and autoimmunity. As Btk does not carry oncogenic modifications, this also establishes a novel therapeutic paradigm, based on targeting ancillary pathways recruited by the pathogenic process to become pivotal to cancer cell's biology. This issue focuses on biology and translation of Tec kinases, at the cross-roads between immunology and cancer.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Faris M,Bot Adoi
10.3109/08830185.2012.671692subject
Has Abstractpub_date
2012-04-01 00:00:00pages
85-6issue
2eissn
0883-0185issn
1563-5244journal_volume
31pub_type
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.747524
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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abstract::The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...
journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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更新日期:1989-01-01 00:00:00
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