Abstract:
:IVIgG preparations are now widely applied for immune modulatory treatment in various forms of autoimmune and immune complex diseases. Several controlled studies clearly demonstrated the clinical efficacy of this type of treatment; the underlying pathophysiological mechanisms, however, have yet to be elucidated. Among the mechanisms suggested to play a role in this context is the interaction of gamma globulin with Fc gamma receptors (Fc gamma R) expressed in the membrane of immunocompetent cells. Our studies concentrated on these aspects and focused on possible functional consequences of IgG-Fc gamma R interaction. By using the peripheral blood monocyte as a model system for an Fc gamma R-bearing cell, we confirmed previous reports by showing differences in Fc gamma R binding and Fc gamma R modulation induced by IgG in its various forms (monomeric IgG, Polymeric IgG, immune complexes). As biological consequences of Fc gamma R modulation, changes in effector and accessory function of these cells were observed. The results presented in this brief review emphasize especially the difference between ligand-oriented Fc gamma R diffusion (induced by surface-bound IgG) and true long-term down-modulation of Fc gamma R (mediated by fluid-phase IgG polymers) and show that only the down-modulation of Fc gamma R correlated with impaired functions of the affected cell.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Mannhalter JW,Eibl MMdoi
10.3109/08830188909061984subject
Has Abstractpub_date
1989-01-01 00:00:00pages
173-9issue
2eissn
0883-0185issn
1563-5244journal_volume
5pub_type
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009056627
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pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809044773
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:International reviews of immunology
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abstract:OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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更新日期:2003-09-01 00:00:00