Abstract:
:The present article summarizes a series of experiments which have been performed to describe an antigen-specific suppressor cell pathway for the suppression of the erythema and edema associated with an animal model of rheumatoid arthritis, collagen induced arthritis (CIA). Initial studies utilized the adoptive transfer of splenic cell subpopulations to establish the presence of suppressor cells in lymphoid tissues of mice which were suppressed for collagen induced arthritis. Subsequent studies generated T cell hybridomas from animals which had been suppressed for collagen induced arthritis by a single injection of a large quantity of Type II collagen. The T cell hybridomas varied in their self surface expression of glycoproteins which are associated with genetically determined functions. The suppressor T cells generated, described a regulatory suppressor cell pathway comprised of at least afferent suppressor T cells and effector suppressor T cells. The cells act in an antigen-specific fashion with regard to the suppression of collagen induced arthritis but appear to be polymorphic in their recognition of the interstitial collagens. The studies, taken together, indicate that the use of antigen specific T suppressor cells in the form of T cell hybridomas can be utilized as a form of immunotherapy in experimental arthritis.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Kresina TFdoi
10.3109/08830188809044773subject
Has Abstractpub_date
1988-09-01 00:00:00pages
91-106issue
1eissn
0883-0185issn
1563-5244journal_volume
4pub_type
杂志文章,评审abstract::T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.829471
更新日期:2013-10-01 00:00:00
abstract::In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2017.1356296
更新日期:2017-11-02 00:00:00
abstract::The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109043039
更新日期:2001-01-01 00:00:00
abstract::Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1592169
更新日期:2019-01-01 00:00:00
abstract::The C-type lectins DC-SIGN, DC-SIGNR and LSECtin are encoded by the lectin gene cluster on chromosome 19p13.3 and perform cell-adhesion and pathogen recognition functions on dendritic cells, liver cells and lymph node sinusoidal endothelial cells. DC-SIGN and DC-SIGNR share similar overall gene and protein molecule st...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.834897
更新日期:2014-01-01 00:00:00
abstract::Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830180902929404
更新日期:2009-01-01 00:00:00
abstract::Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1 and IL-12 occurs during the night and early morning at a time when plasma cortisol is lowest. The existence of a causal relationship between plasma cortisol and production...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809043012
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830185.2020.1869732
更新日期:2021-01-11 00:00:00
abstract::Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spr...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180490265592
更新日期:2004-01-01 00:00:00
abstract::Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to gen...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188909044783
更新日期:1989-01-01 00:00:00
abstract::Myasthenia gravis (MG) is a prototypic antibody-mediated autoimmune disease. Since the primary target antigen of the autoimmune response is known and a well-characterized animal model is available, MG is often considered an excellent situation for the application of novel specific immunotherapies, many of which are di...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189909043020
更新日期:1999-01-01 00:00:00
abstract::Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.829468
更新日期:2014-05-01 00:00:00
abstract::Although the B cell antigen receptor (BCR) transmits survival and activation signals, BCR ligation can induce apoptosis in both immature and mature B cells. BCR-mediated apoptosis is suggested to play a role in self-tolerance by deleting self-reactive B cells. Generation of an apoptotic signal through BCR appears to d...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109045590
更新日期:2001-01-01 00:00:00
abstract::Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokine...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180305224
更新日期:2003-05-01 00:00:00
abstract::Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they m...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.902452
更新日期:2015-01-01 00:00:00
abstract::The B cell repertoire consists of three tiers of clonotype diversity. One tier, which is the product of H chain V region rearrangements in the absence of N additions, is of limited diversity (less than 10(8) clonotypes) so that clonotypes of this tier would be expected to recur within and among B cells of individuals ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209055571
更新日期:1992-01-01 00:00:00
abstract::The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somat...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189709068177
更新日期:1997-01-01 00:00:00
abstract::Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded b...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.879711
更新日期:2015-05-01 00:00:00
abstract::The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188709044749
更新日期:1987-01-01 00:00:00
abstract::CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man, which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells. CD40/CD40L interactions are now known to be essential for the initiation of antibody responses to T-dependent antigens. In this review we discuss th...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189709068169
更新日期:1997-01-01 00:00:00
abstract::The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.3109/08830185.2012.748053
更新日期:2013-06-01 00:00:00
abstract::Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubte...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.3109/08830180009055500
更新日期:2000-01-01 00:00:00
abstract::The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these aut...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180590884648
更新日期:2005-01-01 00:00:00
abstract::Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180500371462
更新日期:2005-09-01 00:00:00
abstract::Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines,...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1018419
更新日期:2015-03-01 00:00:00
abstract::ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive p...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1601720
更新日期:2019-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and enviro...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830181003602507
更新日期:2010-04-01 00:00:00
abstract::Recurrent vulvovaginal candidiasis (RVVC) is a significant problem in women of childbearing ages and is caused by Candida albicans, a commensal organism of the intestinal and reproductive tracts. As a result of this commensalism, most healthy individuals have demonstrable Candida-specific adaptive immunity that is con...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180215015
更新日期:2002-11-01 00:00:00
abstract::While simultaneously maintaining homeostasis and reducing further harm to the host, the immune system is equipped to eliminate both tumors and pathogenic microorganisms. Bifurcated into cell-mediated and humoral immunity, the adaptive immune system requires a series of complex and coordinated signals to drive the prol...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.974748
更新日期:2015-01-01 00:00:00
abstract::Dendritic cells (DC) are the most potent and versatile antigen-presenting cells (APC) in the immune system. DC have an exceptional ability to comprehend the immune context of a captured antigen based on molecular signals identified from its vicinity. The analyzed information is then conveyed to other immune effector c...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1096935
更新日期:2016-01-01 00:00:00