Dendritic Cells in the Context of Human Tumors: Biology and Experimental Tools.

abstract：:The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensi...

journal_title：International reviews of immunology

authors： Chicaybam L,Sodré AL,Bonamino M

更新日期：2011-10-01 00:00:00

abstract：:Leukocytes can't perform phagocytosis in blood stream. Blood velocity prevents phagocytosis because there is no time for leukocyte to recognize and catch bacteria. Bloodstream clearance from pathogens is performed by erythrocytes. During motion in bloodstream erythrocytes become charged by triboelectric effect. This c...

journal_title：International reviews of immunology

authors： Minasyan HA

更新日期：2014-11-01 00:00:00

abstract：:IVIgG preparations are now widely applied for immune modulatory treatment in various forms of autoimmune and immune complex diseases. Several controlled studies clearly demonstrated the clinical efficacy of this type of treatment; the underlying pathophysiological mechanisms, however, have yet to be elucidated. Among ...

journal_title：International reviews of immunology

authors： Mannhalter JW,Eibl MM

更新日期：1989-01-01 00:00:00

abstract：:Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...

journal_title：International reviews of immunology

authors： Daniel V,Opelz G

更新日期：2009-01-01 00:00:00

abstract：:A unifying theory of B cell development and lineage commitment is presented. There are two firmly established B lineages: cells which normally arise only from fetal sources and lack N insertions in their rearranged heavy chains; and N-containing cells which arise from adult bone marrow precursors (and perhaps from lat...

journal_title：International reviews of immunology

authors： Wortis HH

更新日期：1992-01-01 00:00:00

abstract：:The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, ut...

journal_title：International reviews of immunology

authors： Langdon K,Haleagrahara N

更新日期：2018-01-01 00:00:00

abstract：:Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these m...

journal_title：International reviews of immunology

authors： Krensky AM,Clayberger C

更新日期：1996-01-01 00:00:00

abstract：:Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines,...

journal_title：International reviews of immunology

authors： Figueroa JA,Reidy A,Mirandola L,Trotter K,Suvorava N,Figueroa A,Konala V,Aulakh A,Littlefield L,Grizzi F,Rahman RL,Jenkins MR,Musgrove B,Radhi S,D'Cunha N,D'Cunha LN,Hermonat PL,Cobos E,Chiriva-Internati M

更新日期：2015-03-01 00:00:00

abstract：:A technology is described which combines the power of T lymphocytes in eliminating unwanted cells and causing beneficial inflammatory reactions with the great advantages of monoclonal antibodies. We show that heteroconjugate antibodies and hybrid antibodies, in which one of the component binding sites is anti-T-cell r...

journal_title：International reviews of immunology

authors： Staerz UD,Bevan MJ

更新日期：1989-05-01 00:00:00

abstract：:Over the past few decades, advancements in molecular and cell biology have allowed scientists to identify a large number of new antigens from a variety of viral and bacterial pathogens. However, successful development of these antigens into effective vaccines strongly relies on delivery systems able to avoid the rapid...

journal_title：International reviews of immunology

authors： Cutting SM,Hong HA,Baccigalupi L,Ricca E

更新日期：2009-01-01 00:00:00

abstract：:While simultaneously maintaining homeostasis and reducing further harm to the host, the immune system is equipped to eliminate both tumors and pathogenic microorganisms. Bifurcated into cell-mediated and humoral immunity, the adaptive immune system requires a series of complex and coordinated signals to drive the prol...

journal_title：International reviews of immunology

authors： Fracchia KM,Walsh CM

更新日期：2015-01-01 00:00:00

abstract：:Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...

journal_title：International reviews of immunology

authors： Cobos C,Figueroa JA,Mirandola L,Colombo M,Summers G,Figueroa A,Aulakh A,Konala V,Verma R,Riaz J,Wade R,Saadeh C,Rahman RL,Pandey A,Radhi S,Nguyen DD,Jenkins M,Chiriva-Internati M,Cobos E

更新日期：2014-10-01 00:00:00

abstract：:The development of a strong cellular immune response is critical for the control of the intracellular pathogen Toxoplasma gondii. This occurs by activation of a complex, integrated immune response, which utilizes cells of the innate and adaptive immune systems. In the last two decades there have been major advances in...

journal_title：International reviews of immunology

authors： Lieberman LA,Hunter CA

更新日期：2002-07-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT), an autoimmune thyroid disease (AITD), is becoming more and more prevalent in the recent years. Data on family and twin studies carry evidence for strong genetic influence on AITD susceptibility and development. The most common approaches to unravel the background of those diseases are who...

journal_title：International reviews of immunology

authors： Jabrocka-Hybel A,Skalniak A,Piątkowski J,Pach D,Hubalewska-Dydejczyk A

更新日期：2013-06-01 00:00:00

abstract：:Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded b...

journal_title：International reviews of immunology

authors： Zhou XJ,Cheng FJ,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Almost 30 years have passed since adult T-cell leukemia (ATL) was identified as a new disease entity in Japan. During this period, its causative agent, human T-cell leukemia virus (HTLV-1), was discovered, and a crucial role of the viral product Tax in ATL leukemogenesis was demonstrated. Recently, another HTLV-1 prod...

journal_title：International reviews of immunology

authors： Murata K,Yamada Y

更新日期：2007-09-01 00:00:00

abstract：:Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the ...

journal_title：International reviews of immunology

authors： Faris M,Bot A

更新日期：2012-04-01 00:00:00

abstract：:The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these aut...

journal_title：International reviews of immunology

authors： Bergman MP,Vandenbroucke-Grauls CM,Appelmelk BJ,D'Elios MM,Amedei A,Azzurri A,Benagiano M,Del Prete G

更新日期：2005-01-01 00:00:00

abstract：:Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...

journal_title：International reviews of immunology

authors： Offner H,Vandenbark AA

更新日期：2005-09-01 00:00:00

abstract：:Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...

journal_title：International reviews of immunology

authors： Perl A,Gergely P Jr,Banki K

更新日期：2004-05-01 00:00:00

abstract：:The C-type lectins DC-SIGN, DC-SIGNR and LSECtin are encoded by the lectin gene cluster on chromosome 19p13.3 and perform cell-adhesion and pathogen recognition functions on dendritic cells, liver cells and lymph node sinusoidal endothelial cells. DC-SIGN and DC-SIGNR share similar overall gene and protein molecule st...

journal_title：International reviews of immunology

authors： Zhang F,Ren S,Zuo Y

更新日期：2014-01-01 00:00:00

abstract：:Autoimmune disorders afflicting the liver comprise the bona fide autoimmune diseases, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis as well as drug-induced autoimmune-like diseases, such as halothane hepatitis. Whereas drug-induced forms of acute or chronic hepatitis often have a ...

journal_title：International reviews of immunology

authors： Christen U,Hintermann E

更新日期：2014-07-01 00:00:00

abstract：:Dendritic cells (DCs) and macrophages (Mϕs) are professional antigen-presenting cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). It is quite interesting to mention here that DCs and Mϕs use distinct strategies to combat and eliminate Mtb. Simil...

journal_title：International reviews of immunology

authors： Khan N,Vidyarthi A,Pahari S,Agrewala JN

更新日期：2016-09-02 00:00:00

abstract：OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...

journal_title：International reviews of immunology

authors： Marletta S,Girolami I,Munari E,Pantanowitz L,Bernasconi R,Torresani E,Brunelli M,Eccher A

更新日期：2021-01-11 00:00:00

abstract：:Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...

journal_title：International reviews of immunology

authors： Chiriva-Internati M

更新日期：2011-04-01 00:00:00

abstract：:Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in...

journal_title：International reviews of immunology

authors： Nawab A,An L,Wu J,Li G,Liu W,Zhao Y,Wu Q,Xiao M

更新日期：2019-01-01 00:00:00

abstract：:In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, in...

journal_title：International reviews of immunology

authors： Xu LL,Li ZJ,Niu XL,Deng WM

更新日期：2017-11-02 00:00:00

abstract：:Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...

journal_title：International reviews of immunology

authors： Karlen S,De Boer ML,Lipscombe RJ,Lutz W,Mordvinov VA,Sanderson CJ

更新日期：1998-01-01 00:00:00

abstract：:When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved ...

journal_title：International reviews of immunology

authors： Aubert M,Jerome KR

更新日期：2003-09-01 00:00:00

abstract：:In these studies we have emphasized the apparent developmental hierarchy of B cell development and assigned a role for the multispecific self idiotype reactive B cells which develop first, in promoting the development of later appearing clones of B cells. These early sets of interconnecting clones of B cells bridge be...

journal_title：International reviews of immunology

authors： Vakil M,Kearney JF

更新日期：1988-03-01 00:00:00