Abstract:
:Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of cancers in other anatomic locations, such as the head and neck, lung, breast and bladder. In 2006, the first vaccine for HPV, Gardasil, was approved for the prevention of subtypes 6, 11, 16 and 18. A few years later, Cevarix was approved for the prevention of subtypes 16 and 18, the HPV subtypes most frequently implicated in malignant progression. Although increased awareness and vaccination could drastically decrease the incidence of HPV-positive cancers, these approaches do not benefit patients who have already contracted HPV and developed cancer as a result. For this reason, researchers need to continue developing treatment modalities, such as targeted immunotherapies, for HPV-positive lesions. Here, we review the potential evidence linking HPV infection with the development of non-anogenital cancers and the potential role of immunotherapy in the prevention and eradication of HPV infection and its oncogenic sequela.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Cobos C,Figueroa JA,Mirandola L,Colombo M,Summers G,Figueroa A,Aulakh A,Konala V,Verma R,Riaz J,Wade R,Saadeh C,Rahman RL,Pandey A,Radhi S,Nguyen DD,Jenkins M,Chiriva-Internati M,Cobos Edoi
10.3109/08830185.2014.911857subject
Has Abstractpub_date
2014-10-01 00:00:00pages
383-401issue
5eissn
0883-0185issn
1563-5244journal_volume
33pub_type
杂志文章,评审abstract::IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpected...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180009048392
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abstract::Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209056641
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abstract::The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, ut...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830185.2018.1465943
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abstract::The C-type lectins DC-SIGN, DC-SIGNR and LSECtin are encoded by the lectin gene cluster on chromosome 19p13.3 and perform cell-adhesion and pathogen recognition functions on dendritic cells, liver cells and lymph node sinusoidal endothelial cells. DC-SIGN and DC-SIGNR share similar overall gene and protein molecule st...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.834897
更新日期:2014-01-01 00:00:00
abstract::A technology is described which combines the power of T lymphocytes in eliminating unwanted cells and causing beneficial inflammatory reactions with the great advantages of monoclonal antibodies. We show that heteroconjugate antibodies and hybrid antibodies, in which one of the component binding sites is anti-T-cell r...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188909044779
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abstract::Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.829468
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abstract::Dendritic cells (DC) from human peripheral blood are susceptible to productive and probably to latent infection with HIV-I. Infection of DC also occurs in vivo since in HIV-seropositive individuals Langerhans' cells of the skin and DC from peripheral blood, (in preparation) are infected. In peripheral blood 3-25% of D...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009056627
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abstract::Myasthenia gravis (MG) is a prototypic antibody-mediated autoimmune disease. Since the primary target antigen of the autoimmune response is known and a well-characterized animal model is available, MG is often considered an excellent situation for the application of novel specific immunotherapies, many of which are di...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189909043020
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.879711
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189909088490
更新日期:1999-01-01 00:00:00
abstract::The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009061761
更新日期:1990-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180305224
更新日期:2003-05-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809054411
更新日期:1998-01-01 00:00:00
abstract::Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830180902929404
更新日期:2009-01-01 00:00:00
abstract::The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.667180
更新日期:2012-06-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180600992480
更新日期:2006-09-01 00:00:00
abstract::Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the ...
journal_title:International reviews of immunology
pub_type: 社论
doi:10.3109/08830185.2012.671692
更新日期:2012-04-01 00:00:00
abstract::In these studies we have emphasized the apparent developmental hierarchy of B cell development and assigned a role for the multispecific self idiotype reactive B cells which develop first, in promoting the development of later appearing clones of B cells. These early sets of interconnecting clones of B cells bridge be...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809051185
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809043012
更新日期:1998-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188709044749
更新日期:1987-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903281193
更新日期:2010-04-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2016.1276903
更新日期:2017-01-02 00:00:00
abstract::Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its high expression in the testis. Sperm protein 17 expression levels are low or abs...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2011.569903
更新日期:2011-04-01 00:00:00
abstract::Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
abstract::A unifying theory of B cell development and lineage commitment is presented. There are two firmly established B lineages: cells which normally arise only from fetal sources and lack N insertions in their rearranged heavy chains; and N-containing cells which arise from adult bone marrow precursors (and perhaps from lat...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
abstract::Vascular endothelial dysfunction (ED) forms the cornerstone in the development of atherosclerotic lesions that clinically manifest as ischemia, myocardial infarction, stroke or peripheral arterial disease. ED can be triggered by various risk factors including hypercholesterolemia, hypertension, hyperhomocystenemia and...
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abstract::In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, in...
journal_title:International reviews of immunology
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abstract::Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...
journal_title:International reviews of immunology
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abstract::The nuclear factor (NF)-kappa B family of proteins is a key regulator of inflammation, innate immunity, and cell survival and differentiation. Components of these pathways are potential targets of intervention for inflammation, infectious diseases, and cancer. However, therapeutic interventions that dampen the host re...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::Peripheral blood lymphocytes from nonatopic subjects and atopic patients were analyzed for cells expressing Fc receptors for IgE (Fc epsilon R). Nonatopic humans and atopic patients in remission had approximately 1 percent of Fc epsilon R+ peripheral blood lymphocytes. Usually greater than 99 percent of these cells we...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00