Abstract:
:When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved a wide variety of inhibitors of apoptosis. In higher organisms, the outcome of viral infections is largely determined by the immune system. Since apoptosis is intimately linked to the function and regulation of the immune system, the ability of viruses to inhibit apoptosis could profoundly alter the immune response. Viral antiapoptotic proteins could protect infected cells from apoptosis induced by cytotoxic lymphocytes, alter antigen cross-presentation and the priming of the immune response, or modulate the expression of danger signals from sites of infection. The virus/host interaction is likely to provide useful lessons regarding the workings of the mammalian immune system.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Aubert M,Jerome KRdoi
10.1080/08830180305213subject
Has Abstractpub_date
2003-09-01 00:00:00pages
361-71issue
5-6eissn
0883-0185issn
1563-5244pii
BBP7CWDM7YGM4Q6Ejournal_volume
22pub_type
杂志文章,评审abstract::The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189909088497
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abstract::T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.829471
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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更新日期:2004-05-01 00:00:00
abstract::The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these aut...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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pub_type: 社论
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更新日期:2015-05-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2001-06-01 00:00:00
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journal_title:International reviews of immunology
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更新日期:2002-07-01 00:00:00