Abstract:
:Autoimmune disorders afflicting the liver comprise the bona fide autoimmune diseases, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis as well as drug-induced autoimmune-like diseases, such as halothane hepatitis. Whereas drug-induced forms of acute or chronic hepatitis often have a clear triggering factor, the etiology of classical autoimmune liver diseases is only poorly understood. Besides a genetic component present in disease susceptible individuals, environmental triggering factors are likely to play a role in the initiation and/or propagation of the disease. In this article, we will review on current evidence obtained from epidemiological associations, case studies, and findings in animal models for pathogens, to be involved in the etiology of autoimmune liver disease with a special focus on autoimmune hepatitis.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Christen U,Hintermann Edoi
10.3109/08830185.2014.921162subject
Has Abstractpub_date
2014-07-01 00:00:00pages
296-313issue
4eissn
0883-0185issn
1563-5244journal_volume
33pub_type
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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