DNA vaccination and the immune responsiveness of neonates.

abstract：:Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...

journal_title：International reviews of immunology

authors： Pradhan G,Raj Abraham P,Shrivastava R,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Noncoding RNA comprises of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) that are abundantly present in mammalian transcriptome. These noncoding RNAs have been implicated in multiple biological processes through the regulation of gene expression. Each of these noncoding RNAs were found to have multiple genes ta...

journal_title：International reviews of immunology

authors： Roy S,Awasthi A

更新日期：2019-01-01 00:00:00

abstract：:Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded b...

journal_title：International reviews of immunology

authors： Zhou XJ,Cheng FJ,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in...

journal_title：International reviews of immunology

authors： Nawab A,An L,Wu J,Li G,Liu W,Zhao Y,Wu Q,Xiao M

更新日期：2019-01-01 00:00:00

abstract：:Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these m...

journal_title：International reviews of immunology

authors： Krensky AM,Clayberger C

更新日期：1996-01-01 00:00:00

abstract：:ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive p...

journal_title：International reviews of immunology

authors： Dahlgren US,Bennet W

更新日期：2019-01-01 00:00:00

abstract：:Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokine...

journal_title：International reviews of immunology

authors： Brault MS,Kurt RA

更新日期：2003-05-01 00:00:00

abstract：:Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubte...

journal_title：International reviews of immunology

authors： Shirai T,Hirose S

更新日期：2000-01-01 00:00:00

abstract：:The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated ...

journal_title：International reviews of immunology

authors： Tsai HT,Tsai TH,Lu TM,Yang CC

更新日期：2008-01-01 00:00:00

abstract：:Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...

journal_title：International reviews of immunology

authors： Cobos C,Figueroa JA,Mirandola L,Colombo M,Summers G,Figueroa A,Aulakh A,Konala V,Verma R,Riaz J,Wade R,Saadeh C,Rahman RL,Pandey A,Radhi S,Nguyen DD,Jenkins M,Chiriva-Internati M,Cobos E

更新日期：2014-10-01 00:00:00

abstract：:IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpected...

journal_title：International reviews of immunology

authors： Davidson NJ,Fort MM,Müller W,Leach MW,Rennick DM

更新日期：2000-01-01 00:00:00

abstract：:Most contemporary models of hematopoiesis assume lineage fidelity of early progenitor cells. Along with this concept normal hematopoietic cells and the majority of leukemias express exclusively myeloid or lymphoid specific antigens. On the other hand, growing evidence exists challenging the lineage fidelity model. Chr...

journal_title：International reviews of immunology

authors： Schmidt CA,Przybylski GK

更新日期：2001-02-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA. Regulatory mechanisms of the innate...

journal_title：International reviews of immunology

authors： Vollmer J

更新日期：2006-05-01 00:00:00

abstract：:Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...

journal_title：International reviews of immunology

authors： Karlen S,De Boer ML,Lipscombe RJ,Lutz W,Mordvinov VA,Sanderson CJ

更新日期：1998-01-01 00:00:00

abstract：:The development of a strong cellular immune response is critical for the control of the intracellular pathogen Toxoplasma gondii. This occurs by activation of a complex, integrated immune response, which utilizes cells of the innate and adaptive immune systems. In the last two decades there have been major advances in...

journal_title：International reviews of immunology

authors： Lieberman LA,Hunter CA

更新日期：2002-07-01 00:00:00

abstract：:When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved ...

journal_title：International reviews of immunology

authors： Aubert M,Jerome KR

更新日期：2003-09-01 00:00:00

abstract：:Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lym...

journal_title：International reviews of immunology

authors： Zhang Y,Tang J,Tian Z,van Velkinburgh JC,Song J,Wu Y,Ni B

更新日期：2016-09-02 00:00:00

abstract：:Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...

journal_title：International reviews of immunology

authors： Perl A,Gergely P Jr,Banki K

更新日期：2004-05-01 00:00:00

abstract：:Current advances in understanding of the pathogenesis of inflammatory bowel disease have encouraged the development of many new therapies targeted at specific and non-specific mediators of the inflammatory bowel disease inflammatory pathway. Crohn's disease and ulcerative colitis, two common inflammatory bowel disease...

journal_title：International reviews of immunology

authors： Ghosh N,Chaki R,Mandal V,Lin GD,Mandal SC

更新日期：2010-01-01 00:00:00

abstract：:The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these aut...

journal_title：International reviews of immunology

authors： Bergman MP,Vandenbroucke-Grauls CM,Appelmelk BJ,D'Elios MM,Amedei A,Azzurri A,Benagiano M,Del Prete G

更新日期：2005-01-01 00:00:00

abstract：:Immune privilege was first explored in the late 1800s by van Dooremaal, and was then extended by Medawar in the mid 1900s to fit in with emerging concepts of transplantation immunology. Modern concepts and understanding of immune privilege come from subsequent studies produced by Medawar, Billingham, and Streilein. Th...

journal_title：International reviews of immunology

authors： Stein-Streilein J,Streilein JW

更新日期：2002-03-01 00:00:00

abstract：:Genetic alterations of the BCL-6 gene in mice and man have established BCL-6 as a pivotal regulator of normal differentiation of B and T lymphocytes as well as one of the most frequently translocated oncogenes in human B cell lymphomas. As an oncogene, BCL-6 has not been easy to place into existing paradigms of cellul...

journal_title：International reviews of immunology

authors： Staudt LM,Dent AL,Shaffer AL,Yu X

更新日期：1999-01-01 00:00:00

abstract：:A technology is described which combines the power of T lymphocytes in eliminating unwanted cells and causing beneficial inflammatory reactions with the great advantages of monoclonal antibodies. We show that heteroconjugate antibodies and hybrid antibodies, in which one of the component binding sites is anti-T-cell r...

journal_title：International reviews of immunology

authors： Staerz UD,Bevan MJ

更新日期：1989-05-01 00:00:00

abstract：:The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that ...

journal_title：International reviews of immunology

authors： Martinez OM,Krams SM

更新日期：1999-01-01 00:00:00

abstract：:Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to its action on both immune and tumor cells. It has the ability to "precondition" dendritic cells, allowing them to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an ideal therapy for combination with...

journal_title：International reviews of immunology

authors： Khong A,Nelson DJ,Nowak AK,Lake RA,Robinson BW

更新日期：2012-08-01 00:00:00

abstract：:Human membrane and soluble Fc epsilon receptors (Fc epsilon RI, Fc epsilon RII/CD23) and Fc gamma receptors (Fc gamma RI/CD64, Fc gamma RII/CD32, Fc gamma RIII/CD16) have been implicated in a number of diseases. Their functional roles such as capture and clearance of immune complexes, antibody-dependent cell cytotoxic...

journal_title：International reviews of immunology

authors： Rouard H,Tamasdan S,Moncuit J,Moutel S,Michon J,Fridman WH,Teillaud JL

更新日期：1997-01-01 00:00:00

abstract：:The present article summarizes a series of experiments which have been performed to describe an antigen-specific suppressor cell pathway for the suppression of the erythema and edema associated with an animal model of rheumatoid arthritis, collagen induced arthritis (CIA). Initial studies utilized the adoptive transfe...

journal_title：International reviews of immunology

authors： Kresina TF

更新日期：1988-09-01 00:00:00

abstract：:The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...

journal_title：International reviews of immunology

authors： Walton SF,Weir C

更新日期：2012-06-01 00:00:00

abstract：:Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...

journal_title：International reviews of immunology

authors： Daniel V,Opelz G

更新日期：2009-01-01 00:00:00

abstract：:While simultaneously maintaining homeostasis and reducing further harm to the host, the immune system is equipped to eliminate both tumors and pathogenic microorganisms. Bifurcated into cell-mediated and humoral immunity, the adaptive immune system requires a series of complex and coordinated signals to drive the prol...

journal_title：International reviews of immunology

authors： Fracchia KM,Walsh CM

更新日期：2015-01-01 00:00:00