Chicken toll-like receptors and their significance in immune response and disease resistance.

abstract：:Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines,...

journal_title：International reviews of immunology

authors： Figueroa JA,Reidy A,Mirandola L,Trotter K,Suvorava N,Figueroa A,Konala V,Aulakh A,Littlefield L,Grizzi F,Rahman RL,Jenkins MR,Musgrove B,Radhi S,D'Cunha N,D'Cunha LN,Hermonat PL,Cobos E,Chiriva-Internati M

更新日期：2015-03-01 00:00:00

abstract：:The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensi...

journal_title：International reviews of immunology

authors： Chicaybam L,Sodré AL,Bonamino M

更新日期：2011-10-01 00:00:00

abstract：:Autoimmune disorders afflicting the liver comprise the bona fide autoimmune diseases, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis as well as drug-induced autoimmune-like diseases, such as halothane hepatitis. Whereas drug-induced forms of acute or chronic hepatitis often have a ...

journal_title：International reviews of immunology

authors： Christen U,Hintermann E

更新日期：2014-07-01 00:00:00

abstract：:The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...

journal_title：International reviews of immunology

authors： Oggioni MR,Beninati C,Boccanera M,Medaglini D,Spinosa MR,Maggi T,Conti S,Magliani W,De Bernardis F,Teti G,Cassone A,Pozzi G,Polonelli L

更新日期：2001-01-01 00:00:00

abstract：:Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is considered a prototypical autoimmune disorder based mainly on data from experimental models in the mouse. Several different experimental mode...

journal_title：International reviews of immunology

authors： Forrester JV,Klaska IP,Yu T,Kuffova L

更新日期：2013-02-01 00:00:00

abstract：:When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved ...

journal_title：International reviews of immunology

authors： Aubert M,Jerome KR

更新日期：2003-09-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT), an autoimmune thyroid disease (AITD), is becoming more and more prevalent in the recent years. Data on family and twin studies carry evidence for strong genetic influence on AITD susceptibility and development. The most common approaches to unravel the background of those diseases are who...

journal_title：International reviews of immunology

authors： Jabrocka-Hybel A,Skalniak A,Piątkowski J,Pach D,Hubalewska-Dydejczyk A

更新日期：2013-06-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA. Regulatory mechanisms of the innate...

journal_title：International reviews of immunology

authors： Vollmer J

更新日期：2006-05-01 00:00:00

abstract：:Human membrane and soluble Fc epsilon receptors (Fc epsilon RI, Fc epsilon RII/CD23) and Fc gamma receptors (Fc gamma RI/CD64, Fc gamma RII/CD32, Fc gamma RIII/CD16) have been implicated in a number of diseases. Their functional roles such as capture and clearance of immune complexes, antibody-dependent cell cytotoxic...

journal_title：International reviews of immunology

authors： Rouard H,Tamasdan S,Moncuit J,Moutel S,Michon J,Fridman WH,Teillaud JL

更新日期：1997-01-01 00:00:00

abstract：:Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...

journal_title：International reviews of immunology

authors： Perl A,Gergely P Jr,Banki K

更新日期：2004-05-01 00:00:00

abstract：:Myasthenia gravis (MG) is a prototypic antibody-mediated autoimmune disease. Since the primary target antigen of the autoimmune response is known and a well-characterized animal model is available, MG is often considered an excellent situation for the application of novel specific immunotherapies, many of which are di...

journal_title：International reviews of immunology

authors： Infante AJ,Kraig E

更新日期：1999-01-01 00:00:00

abstract：:The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...

journal_title：International reviews of immunology

authors： Sulica A,Morel P,Metes D,Herberman RB

更新日期：2001-06-01 00:00:00

abstract：:Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...

journal_title：International reviews of immunology

authors： Meier D,Rumbo M,Gondolesi GE

更新日期：2014-05-01 00:00:00

abstract：:Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokine...

journal_title：International reviews of immunology

authors： Brault MS,Kurt RA

更新日期：2003-05-01 00:00:00

abstract：:Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...

journal_title：International reviews of immunology

authors： Daniel V,Opelz G

更新日期：2009-01-01 00:00:00

abstract：:The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...

journal_title：International reviews of immunology

authors： Walton SF,Weir C

更新日期：2012-06-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including...

journal_title：International reviews of immunology

authors： Johnson PR,Hirsch VM

更新日期：1992-01-01 00:00:00

abstract：:Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pa...

journal_title：International reviews of immunology

authors： Martorelli D,Muraro E,Merlo A,Turrini R,Rosato A,Dolcetti R

更新日期：2010-08-01 00:00:00

abstract：:Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...

journal_title：International reviews of immunology

authors： Karlen S,De Boer ML,Lipscombe RJ,Lutz W,Mordvinov VA,Sanderson CJ

更新日期：1998-01-01 00:00:00

abstract：:The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of ...

journal_title：International reviews of immunology

authors： Samy E,Wax S,Huard B,Hess H,Schneider P

更新日期：2017-01-02 00:00:00

abstract：:The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...

journal_title：International reviews of immunology

authors： Blaser K,Heusser CH

更新日期：1987-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...

journal_title：International reviews of immunology

authors： Lopes LF,Ruiz Miyazawa KW,de Almeida ER,Serafim KG,de Almeida Gualtieri K,Costa IC,Felipe I,Pavanelli WR,Watanabe MA

更新日期：2013-06-01 00:00:00

abstract：:Heat shock proteins (HSPs) are immunogenic, with the specificity of the immune response provided by the peptides that they chaperone. Binding of cell surface receptors by HSPs is central to the elicitation of the innate and adaptive immune responses obtained after vaccination and also plays a physiologic role in cross...

journal_title：International reviews of immunology

authors： Binder RJ

更新日期：2006-09-01 00:00:00

abstract：:Aberrations of both innate immunity and adaptive immunity in genetically predisposed individuals evoked by environmental factors are suggested to be implicated in pathophysiological processes of systemic lupus erythematosus (SLE). Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded b...

journal_title：International reviews of immunology

authors： Zhou XJ,Cheng FJ,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induc...

journal_title：International reviews of immunology

authors： Verdier J,Ruemmele FM

更新日期：2013-10-01 00:00:00

abstract：:Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I coll...

journal_title：International reviews of immunology

authors： Karsenty G,Park RW

更新日期：1995-01-01 00:00:00

abstract：:Neonates often respond poorly to conventional vaccines or microbial infections. Immaturity of the immune system has been considered to play a role in this regard. However, accumulating evidence shows that in certain conditions, neonatal inoculation of antigens leads to protective immunity. In the particular case of DN...

journal_title：International reviews of immunology

authors： Bot A

更新日期：2000-01-01 00:00:00

abstract：:Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...

journal_title：International reviews of immunology

authors： Pradhan G,Raj Abraham P,Shrivastava R,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Almost 30 years have passed since adult T-cell leukemia (ATL) was identified as a new disease entity in Japan. During this period, its causative agent, human T-cell leukemia virus (HTLV-1), was discovered, and a crucial role of the viral product Tax in ATL leukemogenesis was demonstrated. Recently, another HTLV-1 prod...

journal_title：International reviews of immunology

authors： Murata K,Yamada Y

更新日期：2007-09-01 00:00:00

abstract：:Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modifie...

journal_title：International reviews of immunology

authors： Hilkens CM,Isaacs JD,Thomson AW

更新日期：2010-04-01 00:00:00