Abstract:
:The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to induce a signal transduction cascade and lead to antibody-dependent cell-mediated cytotoxicity (ADCC) as well as release of various cytokines. In addition, interactions with monomeric IgG and FcgammaRIIIa have been demonstrated, which result in negative regulation of NK activity and other immunomodulatory effects. Over the past several years, it has also become increasingly appreciated that human NK cells express a variety of other Fc receptors, including FcmuR, which also can mediate effector and immunoregulatory functions. Also, a novel form of FcgammaR has been demonstrated on human NK cells, termed FcgammaRIIc. Recent molecular studies have shown considerable polymorphism in the genes for FcgammaIIc and the functional consequences are being dissected. This appears to include cross-talk between FcgammaRIIIa and at least some forms of FcgammaRIIc, which may have important functional consequences.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Sulica A,Morel P,Metes D,Herberman RBdoi
10.3109/08830180109054414subject
Has Abstractpub_date
2001-06-01 00:00:00pages
371-414issue
3-4eissn
0883-0185issn
1563-5244journal_volume
20pub_type
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
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更新日期:1997-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2016-07-03 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.921164
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.902452
更新日期:2015-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109043039
更新日期:2001-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209055571
更新日期:1992-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.747524
更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:International reviews of immunology
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189209055576
更新日期:1992-01-01 00:00:00
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journal_title:International reviews of immunology
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-09-02 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章
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更新日期:2021-01-11 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809051185
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更新日期:2014-11-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.921162
更新日期:2014-07-01 00:00:00