Regulation of type I collagen genes expression.


:Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I collagen is a heterotrimer molecule consisting of two alpha 1(I) chains and one alpha 2(I) chain. The two polypeptide chains are synthesized in a 2:1 stoichiometry. The same 2:1 ratio is observed for the rate of synthesis of the corresponding mRNAs. One hypothesis that would explain how this coregulation occurs at the transcriptional level is that common cis-acting elements are present on both genes. These common regulatory elements would bind identical transcription factors displaying the same function. The characterization of the various regulatory elements present in these genes would foster our understanding of the molecular mechanisms controlling type I collagen gene expression in normal and in pathological situations. Over the past few years, several laboratories have identified cis-acting elements in the promoters of the COL1A1 and COL1A2 genes. At least, two of these cis-acting elements are common to both promoters. One is centered by a pentanucleotide CCAAT and binds a ubiquitously expressed heteromeric CCAAT binding factor. A second one is centered by a G-rich region and it binds a new transcription factor called C-Krox.(ABSTRACT TRUNCATED AT 250 WORDS)


Int Rev Immunol


Karsenty G,Park RW




Has Abstract


1995-01-01 00:00:00












  • Recombinant Streptococcus gordonii for mucosal delivery of a scFv microbicidal antibody.

    abstract::The gram-positive bacterium Streptococcus gordonii was engineered to express the microbicidal molecule H6, which is an antiidiotypic single chain antibody mimicking a yeast killer toxin. S. gordonii is a human commensal which we developed as a model system for mucosal delivery of heterologous proteins. The in vivo can...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Oggioni MR,Beninati C,Boccanera M,Medaglini D,Spinosa MR,Maggi T,Conti S,Magliani W,De Bernardis F,Teti G,Cassone A,Pozzi G,Polonelli L

    更新日期:2001-01-01 00:00:00

  • Uveitis in mouse and man.

    abstract::Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is considered a prototypical autoimmune disorder based mainly on data from experimental models in the mouse. Several different experimental mode...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Forrester JV,Klaska IP,Yu T,Kuffova L

    更新日期:2013-02-01 00:00:00

  • Apoptosis prevention as a mechanism of immune evasion.

    abstract::When cells are infected with viruses, they may trigger their apoptosis programs. In unicellular organisms, this may have protected cell populations by limiting viral replication from infected cells. Multicellular organisms can also trigger the apoptosis program after viral infection. In response, viruses have evolved ...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Aubert M,Jerome KR

    更新日期:2003-09-01 00:00:00

  • Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus.

    abstract::Activation, proliferation, or programmed cell death of T lymphocytes are dependent on controlled reactive oxygen intermediates (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta Psi(m)) also plays a decisive role in cell survival by controlling activity of redox-sensit...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Perl A,Gergely P Jr,Banki K

    更新日期:2004-05-01 00:00:00

  • The role of human papilloma virus (HPV) infection in non-anogenital cancer and the promise of immunotherapy: a review.

    abstract::Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Cobos C,Figueroa JA,Mirandola L,Colombo M,Summers G,Figueroa A,Aulakh A,Konala V,Verma R,Riaz J,Wade R,Saadeh C,Rahman RL,Pandey A,Radhi S,Nguyen DD,Jenkins M,Chiriva-Internati M,Cobos E

    更新日期:2014-10-01 00:00:00

  • CD40: a pivotal receptor in the determination of life/death decisions in B lymphocytes.

    abstract::CD40 is a 48 kDa glycoprotein predominantly expressed on B cells in both mouse and man, which interacts with a counterligand (CD40L), expressed on activated CD4+ T cells. CD40/CD40L interactions are now known to be essential for the initiation of antibody responses to T-dependent antigens. In this review we discuss th...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Klaus GG,Choi MS,Lam EW,Johnson-Léger C,Cliff J

    更新日期:1997-01-01 00:00:00

  • ABO-Incompatible Liver Transplantation - A Review of the Historical Background and Results.

    abstract::ABO-incompatible liver transplantation (ABOi LT) using conventional immunosuppression has been considered a contraindication due to the high risk for antibody-mediated complications potentially resulting in graft loss. However, organ shortage has led to the development of anti-A/B antibody reducing immunosuppressive p...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Dahlgren US,Bennet W

    更新日期:2019-01-01 00:00:00

  • Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS.

    abstract::Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Offner H,Vandenbark AA

    更新日期:2005-09-01 00:00:00

  • Endothelial dysfunction sustains immune response in atherosclerosis: potential cause for ineffectiveness of prevailing drugs.

    abstract::Vascular endothelial dysfunction (ED) forms the cornerstone in the development of atherosclerotic lesions that clinically manifest as ischemia, myocardial infarction, stroke or peripheral arterial disease. ED can be triggered by various risk factors including hypercholesterolemia, hypertension, hyperhomocystenemia and...

    journal_title:International reviews of immunology

    pub_type: 杂志文章


    authors: Akhtar S,Sharma A

    更新日期:2021-01-13 00:00:00

  • HLA-G expression in melanomas.

    abstract:OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...

    journal_title:International reviews of immunology

    pub_type: 杂志文章


    authors: Marletta S,Girolami I,Munari E,Pantanowitz L,Bernasconi R,Torresani E,Brunelli M,Eccher A

    更新日期:2021-01-11 00:00:00

  • Editorial: in this issue.

    abstract::In this issue, we are hosting several reviews on topics of broad interests, such as therapeutic or prophylactic antibodies, and the role of autophagy in autoimmunity. ...

    journal_title:International reviews of immunology

    pub_type: 社论


    authors: Bot A

    更新日期:2015-05-01 00:00:00

  • Chimeric antigen receptors in cancer immuno-gene therapy: current status and future directions.

    abstract::The concept of chimeric antigen receptors (CARs) as molecules able to redirect T lymphocytes toward tumor cells is currently being exploited in the field of cancer immunotherapy. Despite promising preliminary results, some clinical trials evidenced limitations for this technology that must be overcome for more extensi...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Chicaybam L,Sodré AL,Bonamino M

    更新日期:2011-10-01 00:00:00

  • Involvement of Fas-Fas ligand interactions in graft rejection.

    abstract::The Fas/Fas ligand (FasL) pathway has been shown to be important in T lymphocyte-mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen-activated lymphocytes. The expression of Fas by commonly transplanted organs such as the heart, lung, kidney, and liver suggests that ...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Martinez OM,Krams SM

    更新日期:1999-01-01 00:00:00

  • Current status of allograft tolerance in intestinal transplantation.

    abstract::Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolera...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Meier D,Rumbo M,Gondolesi GE

    更新日期:2014-05-01 00:00:00

  • What can we learn from leukemia as for the process of lineage commitment in hematopoiesis?

    abstract::Most contemporary models of hematopoiesis assume lineage fidelity of early progenitor cells. Along with this concept normal hematopoietic cells and the majority of leukemias express exclusively myeloid or lymphoid specific antigens. On the other hand, growing evidence exists challenging the lineage fidelity model. Chr...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Schmidt CA,Przybylski GK

    更新日期:2001-02-01 00:00:00

  • The IgE antibody response to the phosphorylcholine hapten.

    abstract::The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Blaser K,Heusser CH

    更新日期:1987-01-01 00:00:00

  • Transcriptomic network support distinct roles of classical and non-classical monocytes in human.

    abstract::Classical and non-classical monocytes are two well-defined subsets of monocytes displaying distinct roles. They differentially express numerous genes relevant to their primary role. Using five independent transcriptomic microarray datasets, we ruled out several inconsistent genes and identified common genes consistent...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Anbazhagan K,Duroux-Richard I,Jorgensen C,Apparailly F

    更新日期:2014-11-01 00:00:00

  • Preface and overview: genetics of SLE; a sine qua non for identification.

    abstract::Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubte...

    journal_title:International reviews of immunology

    pub_type: 杂志文章


    authors: Shirai T,Hirose S

    更新日期:2000-01-01 00:00:00

  • TLR9 in health and disease.

    abstract::Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA. Regulatory mechanisms of the innate...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Vollmer J

    更新日期:2006-05-01 00:00:00

  • Dendritic cells in systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and enviro...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Seitz HM,Matsushima GK

    更新日期:2010-04-01 00:00:00

  • Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer.

    abstract::Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pa...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Martorelli D,Muraro E,Merlo A,Turrini R,Rosato A,Dolcetti R

    更新日期:2010-08-01 00:00:00

  • Ig-binding receptors on human NK cells as effector and regulatory surface molecules.

    abstract::The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Sulica A,Morel P,Metes D,Herberman RB

    更新日期:2001-06-01 00:00:00

  • The protective immune response against vaginal candidiasis: lessons learned from clinical studies and animal models.

    abstract::Recurrent vulvovaginal candidiasis (RVVC) is a significant problem in women of childbearing ages and is caused by Candida albicans, a commensal organism of the intestinal and reproductive tracts. As a result of this commensalism, most healthy individuals have demonstrable Candida-specific adaptive immunity that is con...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Fidel PL Jr

    更新日期:2002-11-01 00:00:00

  • Oral vaccine delivery by recombinant spore probiotics.

    abstract::Over the past few decades, advancements in molecular and cell biology have allowed scientists to identify a large number of new antigens from a variety of viral and bacterial pathogens. However, successful development of these antigens into effective vaccines strongly relies on delivery systems able to avoid the rapid...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Cutting SM,Hong HA,Baccigalupi L,Ricca E

    更新日期:2009-01-01 00:00:00

  • Chimeric antigen receptor engineering: a right step in the evolution of adoptive cellular immunotherapy.

    abstract::Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use of specific monoclonal antibodies, checkpoint inhibitors, cytokines,...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Figueroa JA,Reidy A,Mirandola L,Trotter K,Suvorava N,Figueroa A,Konala V,Aulakh A,Littlefield L,Grizzi F,Rahman RL,Jenkins MR,Musgrove B,Radhi S,D'Cunha N,D'Cunha LN,Hermonat PL,Cobos E,Chiriva-Internati M

    更新日期:2015-03-01 00:00:00

  • Molecular mechanisms for apoptosis induced by signaling through the B cell antigen receptor.

    abstract::Although the B cell antigen receptor (BCR) transmits survival and activation signals, BCR ligation can induce apoptosis in both immature and mature B cells. BCR-mediated apoptosis is suggested to play a role in self-tolerance by deleting self-reactive B cells. Generation of an apoptotic signal through BCR appears to d...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Tsubata T

    更新日期:2001-01-01 00:00:00

  • Clinical relevance of immune monitoring in solid organ transplantation.

    abstract::Transplant recipients receive immunosuppressive drugs to prevent graft rejection and graft loss. Immunosuppressive drugs are dosed according to empiric treatment protocols, which consider the risk of under- or oversuppression, rejection, infection, cancer, and drug side effects. An individualized immunosuppressive pro...

    journal_title:International reviews of immunology

    pub_type: 杂志文章


    authors: Daniel V,Opelz G

    更新日期:2009-01-01 00:00:00

  • Immunopathology of hepatitis B virus infection.

    abstract::The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated ...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Tsai HT,Tsai TH,Lu TM,Yang CC

    更新日期:2008-01-01 00:00:00

  • Heat shock protein vaccines: from bench to bedside.

    abstract::Heat shock proteins (HSPs) are immunogenic, with the specificity of the immune response provided by the peptides that they chaperone. Binding of cell surface receptors by HSPs is central to the elicitation of the innate and adaptive immune responses obtained after vaccination and also plays a physiologic role in cross...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: Binder RJ

    更新日期:2006-09-01 00:00:00

  • Prospects for the treatment of B cell tumors using idiotypic vaccination.

    abstract::Manipulation of the immune system in order specifically to attack autologous tumor cell has been a distant goal, largely due to the poor definition of tumor-associated antigens. By focussing on B cell lymphomas which express a molecularly defined clonal marker, the idiotypic immunoglobulin, it has been possible to gen...

    journal_title:International reviews of immunology

    pub_type: 杂志文章,评审


    authors: George AJ,Stevenson FK

    更新日期:1989-01-01 00:00:00