Abstract:
:Chemokines play an important role in the generation of the immune system and in virtually every aspect of an immune response. The role of chemokines in antitumor immunity has been less straightforward to discern. A dichotomy exists in the field. One area of research has focused on the impact of tumor-derived chemokines, implicating them in everything from metastases to immune suppression. Another area of research has been dedicated to the introduction of chemokines into tumor cells in order to facilitate immune cell recruitment. In this review these two areas of investigation will be explored.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Brault MS,Kurt RAdoi
10.1080/08830180305224subject
Has Abstractpub_date
2003-05-01 00:00:00pages
199-228issue
3-4eissn
0883-0185issn
1563-5244pii
22B4D3R9KL1D12HCjournal_volume
22pub_type
杂志文章,评审abstract::Leukocytes can't perform phagocytosis in blood stream. Blood velocity prevents phagocytosis because there is no time for leukocyte to recognize and catch bacteria. Bloodstream clearance from pathogens is performed by erythrocytes. During motion in bloodstream erythrocytes become charged by triboelectric effect. This c...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.956359
更新日期:2014-11-01 00:00:00
abstract::The receptors on human natural killer 9NK cells which can specifically bind the Fc portion of immunoglobulin molecules (Fc receptors) have been extensively studied. The best known and studied Fc receptor on human NK cells is FcgammaRIIIa. Interactions of NK cells with IgG antibodies via this receptor are well known to...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109054414
更新日期:2001-06-01 00:00:00
abstract::In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2017.1356296
更新日期:2017-11-02 00:00:00
abstract:OBJECTIVE:Human leukocyte antigen G (HLA-G) is a non-classical HLA class I molecule involved in inducing tolerance at the feto-maternal interface and in escape of immune response by tumor cells. The aim of the study is to review the published literature on the expression of HLA-G in malignant melanomas and its clinicop...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.1080/08830185.2020.1869732
更新日期:2021-01-11 00:00:00
abstract::The immune response to the phosphorylcholine (PC) hapten elicited by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to either PC or phenylphosphorylcholine which were designated as group I and II anti-PC antibodies, respectively. We demonstrate that anti-PC IgE antibody expre...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188709044749
更新日期:1987-01-01 00:00:00
abstract::The nuclear factor (NF)-kappa B family of proteins is a key regulator of inflammation, innate immunity, and cell survival and differentiation. Components of these pathways are potential targets of intervention for inflammation, infectious diseases, and cancer. However, therapeutic interventions that dampen the host re...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180802317957
更新日期:2008-01-01 00:00:00
abstract::The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180802295757
更新日期:2008-01-01 00:00:00
abstract::Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1 and IL-12 occurs during the night and early morning at a time when plasma cortisol is lowest. The existence of a causal relationship between plasma cortisol and production...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809043012
更新日期:1998-01-01 00:00:00
abstract::While simultaneously maintaining homeostasis and reducing further harm to the host, the immune system is equipped to eliminate both tumors and pathogenic microorganisms. Bifurcated into cell-mediated and humoral immunity, the adaptive immune system requires a series of complex and coordinated signals to drive the prol...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.974748
更新日期:2015-01-01 00:00:00
abstract::The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.667180
更新日期:2012-06-01 00:00:00
abstract::Classical and non-classical monocytes are two well-defined subsets of monocytes displaying distinct roles. They differentially express numerous genes relevant to their primary role. Using five independent transcriptomic microarray datasets, we ruled out several inconsistent genes and identified common genes consistent...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.902453
更新日期:2014-11-01 00:00:00
abstract::Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1659258
更新日期:2019-01-01 00:00:00
abstract::Almost 30 years have passed since adult T-cell leukemia (ATL) was identified as a new disease entity in Japan. During this period, its causative agent, human T-cell leukemia virus (HTLV-1), was discovered, and a crucial role of the viral product Tax in ATL leukemogenesis was demonstrated. Recently, another HTLV-1 prod...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180701709817
更新日期:2007-09-01 00:00:00
abstract::Despite their functional similarities, peripheral lymphoid tissues are remarkably different according to their developmental properties and structural characteristics, including their specified vasculature. Access of leukocytes to these organs critically depends on their interactions with the local endothelium, where ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1059427
更新日期:2016-11-01 00:00:00
abstract::Dendritic cells (DCs) and macrophages (Mϕs) are professional antigen-presenting cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). It is quite interesting to mention here that DCs and Mϕs use distinct strategies to combat and eliminate Mtb. Simil...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1015718
更新日期:2016-09-02 00:00:00
abstract::The C-type lectins DC-SIGN, DC-SIGNR and LSECtin are encoded by the lectin gene cluster on chromosome 19p13.3 and perform cell-adhesion and pathogen recognition functions on dendritic cells, liver cells and lymph node sinusoidal endothelial cells. DC-SIGN and DC-SIGNR share similar overall gene and protein molecule st...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.834897
更新日期:2014-01-01 00:00:00
abstract::A technology is described which combines the power of T lymphocytes in eliminating unwanted cells and causing beneficial inflammatory reactions with the great advantages of monoclonal antibodies. We show that heteroconjugate antibodies and hybrid antibodies, in which one of the component binding sites is anti-T-cell r...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188909044779
更新日期:1989-05-01 00:00:00
abstract::Human membrane and soluble Fc epsilon receptors (Fc epsilon RI, Fc epsilon RII/CD23) and Fc gamma receptors (Fc gamma RI/CD64, Fc gamma RII/CD32, Fc gamma RIII/CD16) have been implicated in a number of diseases. Their functional roles such as capture and clearance of immune complexes, antibody-dependent cell cytotoxic...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189709045707
更新日期:1997-01-01 00:00:00
abstract::Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different To...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.921164
更新日期:2014-11-01 00:00:00
abstract::The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.3109/08830185.2012.748053
更新日期:2013-06-01 00:00:00
abstract::Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spr...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180490265592
更新日期:2004-01-01 00:00:00
abstract::T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2013.829471
更新日期:2013-10-01 00:00:00
abstract::Dendritic cells (DC) are the most potent and versatile antigen-presenting cells (APC) in the immune system. DC have an exceptional ability to comprehend the immune context of a captured antigen based on molecular signals identified from its vicinity. The analyzed information is then conveyed to other immune effector c...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1096935
更新日期:2016-01-01 00:00:00
abstract::Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA. Regulatory mechanisms of the innate...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180600743107
更新日期:2006-05-01 00:00:00
abstract::Autoimmune disorders afflicting the liver comprise the bona fide autoimmune diseases, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis as well as drug-induced autoimmune-like diseases, such as halothane hepatitis. Whereas drug-induced forms of acute or chronic hepatitis often have a ...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.921162
更新日期:2014-07-01 00:00:00
abstract::IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpected...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180009048392
更新日期:2000-01-01 00:00:00
abstract::Over the past 30 years, human papilloma virus (HPV) has been shown to play a role in the development of various cancers. Most notably, HPV has been linked to malignant progression in neoplasms of the anogenital region. However, high-risk HPV has also been suggested to play a significant role in the development of canc...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.911857
更新日期:2014-10-01 00:00:00
abstract::Current advances in understanding of the pathogenesis of inflammatory bowel disease have encouraged the development of many new therapies targeted at specific and non-specific mediators of the inflammatory bowel disease inflammatory pathway. Crohn's disease and ulcerative colitis, two common inflammatory bowel disease...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903437212
更新日期:2010-01-01 00:00:00
abstract::The development of a strong cellular immune response is critical for the control of the intracellular pathogen Toxoplasma gondii. This occurs by activation of a complex, integrated immune response, which utilizes cells of the innate and adaptive immune systems. In the last two decades there have been major advances in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180213281
更新日期:2002-07-01 00:00:00
abstract::The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manife...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009061761
更新日期:1990-01-01 00:00:00