Abstract:
:Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lymphoid cells (ILCs), which are mainly localize to epithelial surfaces, have been characterized as regulators of chronic inflammation and tissue remodeling, representing a functional bridge between the innate and adaptive immunity. Moreover, recent research has implicated ILCs as potential contributing factors to several kinds of fibrosis diseases, such as hepatic fibrosis and pulmonary fibrosis. Here, we will summarize and discuss the key roles of ILCs and their related factors in fibrotic diseases and their potential for translation to the clinic.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Zhang Y,Tang J,Tian Z,van Velkinburgh JC,Song J,Wu Y,Ni Bdoi
10.3109/08830185.2015.1068304subject
Has Abstractpub_date
2016-09-02 00:00:00pages
399-414issue
5eissn
0883-0185issn
1563-5244journal_volume
35pub_type
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