Abstract:
:Peripheral blood lymphocytes from nonatopic subjects and atopic patients were analyzed for cells expressing Fc receptors for IgE (Fc epsilon R). Nonatopic humans and atopic patients in remission had approximately 1 percent of Fc epsilon R+ peripheral blood lymphocytes. Usually greater than 99 percent of these cells were mIgM+/mIgD+ B cells. However, in approximately 10 percent of nonatopic and atopic subjects a transient increase of Fc epsilon R+ lymphocytes to 3-6 percent was observed in the absence of any disease manifestations and measurable changes in the serum IgE level. At times of increased numbers of peripheral blood Fc epsilon R+ lymphocytes, up to 1 percent Fc epsilon R+ positive cells were detected in isolated T cell preparations. The Fc epsilon R+ T cells reacted with the monoclonal antibody Lyt 3 to the sheep erythrocyte receptor of human T cells but not the anti-T cell antibody OKT3, and fractions also with the monoclonal antibodies OKT8 (cytotoxic and suppressor T cells) and OKM1, which binds to an antigen present on monocytes and a subpopulation of T cells and large granular lymphocytes. No OKT4+ (helper T cells) Fc epsilon R+ cells were detected. The reactivity with monoclonal antibodies to T cell subsets of the Fc epsilon R+ T cells paralleled the reactivity of the IgG Fc receptor positive T cells. In contrast to patients with allergic rhinitis and asthma, patients with severe atopic dermatitis or the Hyper IgE Syndrome always had significantly elevated percentage of Fc epsilon R+ lymphocytes (4-10 percent), which were almost entirely B cells since less than 0.1 percent Fc epsilon R+ T cells were detected in these patients. Atopic dermatitis patients receiving systemic corticosteroid treatment had only 0.2 percent Fc epsilon R+ lymphocytes which was significantly less than the 1 percent of the nonatopic control donors. Attempts to define the function of Fc epsilon R on human B and T lymphocytes have been unsuccessful thus far; however, the increase of Fc epsilon R+ cells associated with atopic disease in man and parasitic infections in rats and mice suggest that Fc epsilon R+ lymphocyte may be involved in the IgE isotype regulation.
journal_name
Int Rev Immunoljournal_title
International reviews of immunologyauthors
Spiegelberg HLdoi
10.3109/08830188709044747subject
Has Abstractpub_date
1987-01-01 00:00:00pages
63-74issue
1eissn
0883-0185issn
1563-5244journal_volume
2pub_type
杂志文章,评审abstract::The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental ef...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.667180
更新日期:2012-06-01 00:00:00
abstract::Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these m...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189609061746
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abstract::The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNA...
journal_title:International reviews of immunology
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
abstract::Clinical manifestations of systemic lupus erythematosus (SLE) are extremely diverse and variable, mainly because SLE is a multi-factorial disease. Variable combinations of contributing genes at multiple loci in individual patients probably result in diverse disease phenotypes. Genes that predispose to SLE are undoubte...
journal_title:International reviews of immunology
pub_type: 杂志文章
doi:10.3109/08830180009055500
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abstract::Myasthenia gravis (MG) is a prototypic antibody-mediated autoimmune disease. Since the primary target antigen of the autoimmune response is known and a well-characterized animal model is available, MG is often considered an excellent situation for the application of novel specific immunotherapies, many of which are di...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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abstract::Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affect multiple organs. The underlying mechanism that triggers and sustains disease are complex and involve certain susceptibility genes and enviro...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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abstract::Uveitis is underappreciated as a sight-threatening cause of blindness. There are two broad causative classes of uveitis: infectious and non-infectious. Non-infectious uveitis is considered a prototypical autoimmune disorder based mainly on data from experimental models in the mouse. Several different experimental mode...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
abstract::Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189509056711
更新日期:1995-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180109056725
更新日期:2001-02-01 00:00:00
abstract::Leukocytes can't perform phagocytosis in blood stream. Blood velocity prevents phagocytosis because there is no time for leukocyte to recognize and catch bacteria. Bloodstream clearance from pathogens is performed by erythrocytes. During motion in bloodstream erythrocytes become charged by triboelectric effect. This c...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.956359
更新日期:2014-11-01 00:00:00
abstract::In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, in...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2017.1356296
更新日期:2017-11-02 00:00:00
abstract::Cell metabolism is closely related to the host immunity in many respects. We herein briefly summarized the recent progress on the roles of cellular metabolism in T-cell development, homeostasis, differentiation and functions. Relatively quiescent naïve T cells only require energy for survival and migration, and they m...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2014.902452
更新日期:2015-01-01 00:00:00
abstract::Dendritic cells (DC) from human peripheral blood are susceptible to productive and probably to latent infection with HIV-I. Infection of DC also occurs in vivo since in HIV-seropositive individuals Langerhans' cells of the skin and DC from peripheral blood, (in preparation) are infected. In peripheral blood 3-25% of D...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189009056627
更新日期:1990-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188809044773
更新日期:1988-09-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830180903281185
更新日期:2010-04-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830185.2019.1601720
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188909044779
更新日期:1989-05-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180490265592
更新日期:2004-01-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2015.1015718
更新日期:2016-09-02 00:00:00
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journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830188909061984
更新日期:1989-01-01 00:00:00
abstract::Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to its action on both immune and tumor cells. It has the ability to "precondition" dendritic cells, allowing them to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an ideal therapy for combination with...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830185.2012.698338
更新日期:2012-08-01 00:00:00
abstract::The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somat...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189709068177
更新日期:1997-01-01 00:00:00
abstract::Phagosome-lysosome (P-L) fusion is one of the central immune-effector responses of host. It is known that phagosome maturation process is associated with numerous signaling cascades and among these, important role of calcium (Ca2+) signaling has been realized recently. Ca2+ plays key roles in actin rearrangement, acti...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
abstract::Immune privilege was first explored in the late 1800s by van Dooremaal, and was then extended by Medawar in the mid 1900s to fit in with emerging concepts of transplantation immunology. Modern concepts and understanding of immune privilege come from subsequent studies produced by Medawar, Billingham, and Streilein. Th...
journal_title:International reviews of immunology
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abstract::Two of the key events in the pathogenesis of rheumatoid arthritis are the synovial cell proliferation and lymphocyte infiltration into the synovium. The resulting synovitis is longlasting and leads to destructive arthritis, which is a hallmark of rheumatoid arthritis. Accumulating evidence suggests that one of the key...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.3109/08830189809054411
更新日期:1998-01-01 00:00:00
abstract::Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the Fo...
journal_title:International reviews of immunology
pub_type: 杂志文章,评审
doi:10.1080/08830180500371462
更新日期:2005-09-01 00:00:00
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journal_title:International reviews of immunology
pub_type: 社论
doi:10.3109/08830185.2012.671692
更新日期:2012-04-01 00:00:00
abstract::The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, ut...
journal_title:International reviews of immunology
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更新日期:2018-01-01 00:00:00