Abstract:
:The aim of this work is to evaluate the feasibility of hydrophilic silica aerogels as drug carriers and to investigate the influence of the aerogels properties on the release rate of poorly water-soluble drugs. Hydrophilic silica aerogels of different densities were loaded with two model drugs, ketoprofen and griseofulvin, by adsorption from their solution in supercritical CO2. It is demonstrated that up to 30 wt% of ketoprofen and 5.4 wt% of griseofulvin can be deposited on hydrophilic aerogels through physical adsorption. The obtained drug-aerogel formulations were characterized by IR- and UV-spectroscopy, X-ray diffraction and scanning electron microscopy. Release kinetics of both drugs were studied in vitro. The release rate of ketoprofen from the drug-aerogel formulation is much faster than that of the corresponding crystalline drugs. The release rate of ketoprofen increases in 500% and that of griseofulvin in 450%, respectively. The reasons for the release enhancement are the enlarged specific surface area of drugs by adsorption on aerogels compared to their crystalline form and the immediate collapse of aerogel network in aqueous media. The dissolution rate of poorly water soluble drugs can be significantly enhanced by adsorption on highly porous hydrophilic silica aerogels.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Smirnova I,Suttiruengwong S,Seiler M,Arlt Wdoi
10.1081/pdt-200035804subject
Has Abstractpub_date
2004-11-01 00:00:00pages
443-52issue
4eissn
1083-7450issn
1097-9867journal_volume
9pub_type
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